PDR3, a new yeast regulatory gene, is homologous toPDR1 and controls the multidrug resistance phenomenon View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

Thierry Delaveau, Agnès Delahodde, Elvira Carvajal, Julius Subik, Claude Jacq

ABSTRACT

The Saccharomyces cerevisiae PDR3 gene, located near the centromere of chromosome II, has been completely sequenced and characterised. Mutations pdr3-1 and pdr3-2, which confer resistance to several antibiotics can be complemented by a wild-type allele of the PDR3 gene. The sequence of the wild-type PDR3 gene revealed the presence of a long open reading frame capable of encoding a 976-amino acid protein. The protein contains a single Zn(II)2Cys6 binuclear-type zinc finger homologous to the DNA-binding motifs of other transcriptional activators from lower eukaryotes. Evidence that the PDR3 protein is a transcriptional activator was provided by demonstrating that DNA-bound LexA-PDR3 fusion proteins stimulate expression of a nearby promoter containing LexA binding sites. The use of LexA-PDR3 fusions revealed that the protein contains two activation domains, one localised near the N-terminal, cysteine-rich domain and the other localised at the C-terminus. The salient feature of the PDR3 protein is its similarity to the protein coded by PDR1, a gene responsible for pleiotropic drug resistance. The two proteins show 36% amino acid identity over their entire length and their zinc finger DNA-binding domains are highly conserved. The fact that the absence of both PDR1 and PDR3 (simultaneous disruption of the two genes) enhances multidrug sensitivity strongly suggests that the two transcriptional factors have closely related functions. More... »

PAGES

501-511

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00583901

DOI

http://dx.doi.org/10.1007/bf00583901

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007826653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8078477


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Microbial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microbial Sensitivity Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Open Reading Frames", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Restriction Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Alignment", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Nucleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zinc Fingers", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, CNRS URA 1302, Ecole Normale Sup\u00e9rieure 46 rue d'Ulm, 75230, Paris Cedex 05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delaveau", 
        "givenName": "Thierry", 
        "id": "sg:person.01173021134.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173021134.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, CNRS URA 1302, Ecole Normale Sup\u00e9rieure 46 rue d'Ulm, 75230, Paris Cedex 05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delahodde", 
        "givenName": "Agn\u00e8s", 
        "id": "sg:person.0723636366.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723636366.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 Catholique de Louvain", 
          "id": "https://www.grid.ac/institutes/grid.7942.8", 
          "name": [
            "Unite de Biochimie Physiologique, Universit\u00e9 de Louvain, Place Croix du Sud, 2-20, B-1348, Louvain-La-Neuve, Belgium"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carvajal", 
        "givenName": "Elvira", 
        "id": "sg:person.07367311271.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07367311271.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Comenius University", 
          "id": "https://www.grid.ac/institutes/grid.7634.6", 
          "name": [
            "Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Mlynska dolina B2, 842 15, Bratislava, Slovak Republic"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Subik", 
        "givenName": "Julius", 
        "id": "sg:person.052027144.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.052027144.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, CNRS URA 1302, Ecole Normale Sup\u00e9rieure 46 rue d'Ulm, 75230, Paris Cedex 05, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacq", 
        "givenName": "Claude", 
        "id": "sg:person.0613241513.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613241513.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0378-1119(87)90131-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001297840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(87)90131-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001297840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.7.3006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002641408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.6.1.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004700702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00317932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005780555", 
          "https://doi.org/10.1007/bf00317932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00317932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005780555", 
          "https://doi.org/10.1007/bf00317932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.6.3194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006256200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.7.3.1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006310600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00419988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006707200", 
          "https://doi.org/10.1007/bf00419988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00419988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006707200", 
          "https://doi.org/10.1007/bf00419988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90606-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010619589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.5.2609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012398017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.7.3872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012997371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(74)90979-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013227521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1977.tb11317.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013667036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(82)90211-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014139755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(88)90575-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015154338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-2836(89)90438-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015212318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/15.19.7991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015748046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.4.1719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018992187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00410914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020400892", 
          "https://doi.org/10.1007/bf00410914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00410914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020400892", 
          "https://doi.org/10.1007/bf00410914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90081-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020523170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/340724a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021630509", 
          "https://doi.org/10.1038/340724a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/yea.320070609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024309060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/yea.320070609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024309060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.20.9410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025200026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.74.12.5463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025360556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.1.68", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025799673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(91)90048-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026537533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-1119(91)90048-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026537533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00260493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028865811", 
          "https://doi.org/10.1007/bf00260493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00260493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028865811", 
          "https://doi.org/10.1007/bf00260493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/yea.320080909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029507758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/yea.320080909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029507758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00351651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030044789", 
          "https://doi.org/10.1007/bf00351651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00351651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030044789", 
          "https://doi.org/10.1007/bf00351651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(84)80002-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030493170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-2836(84)80002-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030493170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/356408a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031743990", 
          "https://doi.org/10.1038/356408a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.13.1.462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032914730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.6.2077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033979305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/324407a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036417723", 
          "https://doi.org/10.1038/324407a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/356448a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037459102", 
          "https://doi.org/10.1038/356448a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(91)90128-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037778234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(91)90128-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037778234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90063-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040690251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.11.5746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041442446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00277115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043029891", 
          "https://doi.org/10.1007/bf00277115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00277115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043029891", 
          "https://doi.org/10.1007/bf00277115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.11.5735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047275095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1986.tb09640.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049550939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.1.476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051482968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/15.13.5261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059931685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8346441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062654769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078400624", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb07463.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078411349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078442179", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079679844", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081686296", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082743107", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-09", 
    "datePublishedReg": "1994-09-01", 
    "description": "The Saccharomyces cerevisiae PDR3 gene, located near the centromere of chromosome II, has been completely sequenced and characterised. Mutations pdr3-1 and pdr3-2, which confer resistance to several antibiotics can be complemented by a wild-type allele of the PDR3 gene. The sequence of the wild-type PDR3 gene revealed the presence of a long open reading frame capable of encoding a 976-amino acid protein. The protein contains a single Zn(II)2Cys6 binuclear-type zinc finger homologous to the DNA-binding motifs of other transcriptional activators from lower eukaryotes. Evidence that the PDR3 protein is a transcriptional activator was provided by demonstrating that DNA-bound LexA-PDR3 fusion proteins stimulate expression of a nearby promoter containing LexA binding sites. The use of LexA-PDR3 fusions revealed that the protein contains two activation domains, one localised near the N-terminal, cysteine-rich domain and the other localised at the C-terminus. The salient feature of the PDR3 protein is its similarity to the protein coded by PDR1, a gene responsible for pleiotropic drug resistance. The two proteins show 36% amino acid identity over their entire length and their zinc finger DNA-binding domains are highly conserved. The fact that the absence of both PDR1 and PDR3 (simultaneous disruption of the two genes) enhances multidrug sensitivity strongly suggests that the two transcriptional factors have closely related functions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00583901", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297380", 
        "issn": [
          "1617-4615", 
          "1432-1874"
        ], 
        "name": "Molecular Genetics and Genomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "244"
      }
    ], 
    "name": "PDR3, a new yeast regulatory gene, is homologous toPDR1 and controls the multidrug resistance phenomenon", 
    "pagination": "501-511", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00583901"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "25480456dc23c7d3fbc27d35442b6d1770110e6564ed10e5837c7e369c9b5ae1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007826653"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0125036"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8078477"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00583901", 
      "https://app.dimensions.ai/details/publication/pub.1007826653"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T08:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91428_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00583901"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00583901'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00583901'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00583901'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00583901'


 

This table displays all metadata directly associated to this object as RDF triples.

340 TRIPLES      21 PREDICATES      99 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00583901 schema:about N01a31b26b56d4215be664ee8e62a85b7
2 N32ac26794e0c4893b1fe16d28fb23136
3 N4d87b3329ddd4907ad8800974cacfdc7
4 N575803f8e1874a828f92d276a65f60e6
5 N5dab18bf848c451db3e1b3aec586c1f1
6 N70a550b06c10450ca7fdfdfccff9a578
7 N757885c26f554fe282c7bd58dfe71b33
8 N7682213580704ff1874d6885e6affca9
9 N7877ed1321864278ab677b768cd8d0bd
10 Na4fc4265f5474717b18aeb3bd911b59b
11 Na774e36aa071411fa3dffc1b74ef3a8b
12 Nb7e37e7d76254c71bdd40880611858f6
13 Nc20d5519160d48d7834dbfe2ab051eb8
14 Ncd9b0f4a51d04405965ec564b3024a76
15 Ncfd79a7be98f4809aac9be54024605a5
16 Nd6c51e5b4a1545e5a5064f3e13c0171a
17 Ndd993b10af6a4bfdafbad3949f6a6aad
18 Ne31ed4e9189a4b80be5db74c330c1ce9
19 Ned689c6be321425299e00c9e29f5ae24
20 Nf28e4f2d11c34f7f8cd7ad4aec4eca0d
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author N51820635938244b88563bfb7c5ebad54
24 schema:citation sg:pub.10.1007/bf00260493
25 sg:pub.10.1007/bf00277115
26 sg:pub.10.1007/bf00317932
27 sg:pub.10.1007/bf00351651
28 sg:pub.10.1007/bf00410914
29 sg:pub.10.1007/bf00419988
30 sg:pub.10.1038/324407a0
31 sg:pub.10.1038/340724a0
32 sg:pub.10.1038/356408a0
33 sg:pub.10.1038/356448a0
34 https://app.dimensions.ai/details/publication/pub.1076750128
35 https://app.dimensions.ai/details/publication/pub.1078400624
36 https://app.dimensions.ai/details/publication/pub.1078442179
37 https://app.dimensions.ai/details/publication/pub.1079679844
38 https://app.dimensions.ai/details/publication/pub.1081686296
39 https://app.dimensions.ai/details/publication/pub.1082743107
40 https://doi.org/10.1002/j.1460-2075.1990.tb07463.x
41 https://doi.org/10.1002/yea.320070609
42 https://doi.org/10.1002/yea.320080909
43 https://doi.org/10.1016/0006-291x(74)90979-6
44 https://doi.org/10.1016/0022-2836(88)90575-x
45 https://doi.org/10.1016/0022-2836(89)90438-5
46 https://doi.org/10.1016/0092-8674(82)90211-2
47 https://doi.org/10.1016/0092-8674(87)90081-x
48 https://doi.org/10.1016/0092-8674(89)90063-9
49 https://doi.org/10.1016/0092-8674(89)90606-5
50 https://doi.org/10.1016/0304-4165(91)90128-4
51 https://doi.org/10.1016/0378-1119(87)90131-4
52 https://doi.org/10.1016/0378-1119(91)90048-g
53 https://doi.org/10.1016/s0022-2836(84)80002-9
54 https://doi.org/10.1073/pnas.74.12.5463
55 https://doi.org/10.1073/pnas.87.6.2077
56 https://doi.org/10.1073/pnas.89.20.9410
57 https://doi.org/10.1093/nar/15.13.5261
58 https://doi.org/10.1093/nar/15.19.7991
59 https://doi.org/10.1101/gad.6.1.93
60 https://doi.org/10.1111/j.1432-1033.1977.tb11317.x
61 https://doi.org/10.1111/j.1432-1033.1986.tb09640.x
62 https://doi.org/10.1126/science.8346441
63 https://doi.org/10.1128/mcb.10.6.3194
64 https://doi.org/10.1128/mcb.11.1.476
65 https://doi.org/10.1128/mcb.11.11.5735
66 https://doi.org/10.1128/mcb.11.11.5746
67 https://doi.org/10.1128/mcb.11.5.2609
68 https://doi.org/10.1128/mcb.12.1.68
69 https://doi.org/10.1128/mcb.12.4.1719
70 https://doi.org/10.1128/mcb.12.7.3006
71 https://doi.org/10.1128/mcb.13.1.462
72 https://doi.org/10.1128/mcb.13.7.3872
73 https://doi.org/10.1128/mcb.7.3.1111
74 schema:datePublished 1994-09
75 schema:datePublishedReg 1994-09-01
76 schema:description The Saccharomyces cerevisiae PDR3 gene, located near the centromere of chromosome II, has been completely sequenced and characterised. Mutations pdr3-1 and pdr3-2, which confer resistance to several antibiotics can be complemented by a wild-type allele of the PDR3 gene. The sequence of the wild-type PDR3 gene revealed the presence of a long open reading frame capable of encoding a 976-amino acid protein. The protein contains a single Zn(II)2Cys6 binuclear-type zinc finger homologous to the DNA-binding motifs of other transcriptional activators from lower eukaryotes. Evidence that the PDR3 protein is a transcriptional activator was provided by demonstrating that DNA-bound LexA-PDR3 fusion proteins stimulate expression of a nearby promoter containing LexA binding sites. The use of LexA-PDR3 fusions revealed that the protein contains two activation domains, one localised near the N-terminal, cysteine-rich domain and the other localised at the C-terminus. The salient feature of the PDR3 protein is its similarity to the protein coded by PDR1, a gene responsible for pleiotropic drug resistance. The two proteins show 36% amino acid identity over their entire length and their zinc finger DNA-binding domains are highly conserved. The fact that the absence of both PDR1 and PDR3 (simultaneous disruption of the two genes) enhances multidrug sensitivity strongly suggests that the two transcriptional factors have closely related functions.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree false
80 schema:isPartOf N125921dc8b5a427c80abefbee47e23f3
81 Ne7e586c3a86a4093bcc5d4cee6150214
82 sg:journal.1297380
83 schema:name PDR3, a new yeast regulatory gene, is homologous toPDR1 and controls the multidrug resistance phenomenon
84 schema:pagination 501-511
85 schema:productId N00ab925fa1334b2eb785b4a63a85271f
86 N128d7562337446a187e92d573a453e5f
87 N19092d5634084075a9a8f9070faa167a
88 N67c9c4324d4d4429a0e72557f2f94476
89 N89ef117050f540cf8b8b92fdd348a1c9
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007826653
91 https://doi.org/10.1007/bf00583901
92 schema:sdDatePublished 2019-04-15T08:58
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N9470b98da11e46c48564dc1e3ec423b2
95 schema:url http://link.springer.com/10.1007/BF00583901
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N00ab925fa1334b2eb785b4a63a85271f schema:name pubmed_id
100 schema:value 8078477
101 rdf:type schema:PropertyValue
102 N01a31b26b56d4215be664ee8e62a85b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Molecular Sequence Data
104 rdf:type schema:DefinedTerm
105 N024ba285c0384caeb05e8701ddaeb2e5 schema:name Laboratoire de Génétique Moléculaire, CNRS URA 1302, Ecole Normale Supérieure 46 rue d'Ulm, 75230, Paris Cedex 05, France
106 rdf:type schema:Organization
107 N125921dc8b5a427c80abefbee47e23f3 schema:volumeNumber 244
108 rdf:type schema:PublicationVolume
109 N128d7562337446a187e92d573a453e5f schema:name doi
110 schema:value 10.1007/bf00583901
111 rdf:type schema:PropertyValue
112 N19092d5634084075a9a8f9070faa167a schema:name nlm_unique_id
113 schema:value 0125036
114 rdf:type schema:PropertyValue
115 N32ac26794e0c4893b1fe16d28fb23136 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Restriction Mapping
117 rdf:type schema:DefinedTerm
118 N36e977dcef7643409301154163adfd20 rdf:first sg:person.0723636366.35
119 rdf:rest N44ebd27c483d4b1daf6a52daeb3b8db5
120 N44ebd27c483d4b1daf6a52daeb3b8db5 rdf:first sg:person.07367311271.94
121 rdf:rest N997ece1ae0e14357bb3f53963db79074
122 N4d87b3329ddd4907ad8800974cacfdc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Drug Resistance, Microbial
124 rdf:type schema:DefinedTerm
125 N51820635938244b88563bfb7c5ebad54 rdf:first sg:person.01173021134.53
126 rdf:rest N36e977dcef7643409301154163adfd20
127 N575803f8e1874a828f92d276a65f60e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Sequence Homology, Nucleic Acid
129 rdf:type schema:DefinedTerm
130 N5b2ce07553194ba2a055e18ea6c0c903 schema:name Laboratoire de Génétique Moléculaire, CNRS URA 1302, Ecole Normale Supérieure 46 rue d'Ulm, 75230, Paris Cedex 05, France
131 rdf:type schema:Organization
132 N5dab18bf848c451db3e1b3aec586c1f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name DNA, Fungal
134 rdf:type schema:DefinedTerm
135 N67c9c4324d4d4429a0e72557f2f94476 schema:name dimensions_id
136 schema:value pub.1007826653
137 rdf:type schema:PropertyValue
138 N70a550b06c10450ca7fdfdfccff9a578 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Transcription Factors
140 rdf:type schema:DefinedTerm
141 N757885c26f554fe282c7bd58dfe71b33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Saccharomyces cerevisiae Proteins
143 rdf:type schema:DefinedTerm
144 N7682213580704ff1874d6885e6affca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Microbial Sensitivity Tests
146 rdf:type schema:DefinedTerm
147 N7877ed1321864278ab677b768cd8d0bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Genes, Regulator
149 rdf:type schema:DefinedTerm
150 N83d4543ff2b247d8be47df6470790521 rdf:first sg:person.0613241513.43
151 rdf:rest rdf:nil
152 N89ef117050f540cf8b8b92fdd348a1c9 schema:name readcube_id
153 schema:value 25480456dc23c7d3fbc27d35442b6d1770110e6564ed10e5837c7e369c9b5ae1
154 rdf:type schema:PropertyValue
155 N9470b98da11e46c48564dc1e3ec423b2 schema:name Springer Nature - SN SciGraph project
156 rdf:type schema:Organization
157 N997ece1ae0e14357bb3f53963db79074 rdf:first sg:person.052027144.50
158 rdf:rest N83d4543ff2b247d8be47df6470790521
159 Na4fc4265f5474717b18aeb3bd911b59b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Saccharomyces cerevisiae
161 rdf:type schema:DefinedTerm
162 Na774e36aa071411fa3dffc1b74ef3a8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Base Sequence
164 rdf:type schema:DefinedTerm
165 Nb7e37e7d76254c71bdd40880611858f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Chromosomes, Fungal
167 rdf:type schema:DefinedTerm
168 Nc20d5519160d48d7834dbfe2ab051eb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Amino Acid Sequence
170 rdf:type schema:DefinedTerm
171 Ncd9b0f4a51d04405965ec564b3024a76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Recombinant Fusion Proteins
173 rdf:type schema:DefinedTerm
174 Ncfd79a7be98f4809aac9be54024605a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Zinc Fingers
176 rdf:type schema:DefinedTerm
177 Nd6c51e5b4a1545e5a5064f3e13c0171a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Sequence Alignment
179 rdf:type schema:DefinedTerm
180 Ndd993b10af6a4bfdafbad3949f6a6aad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gene Expression Regulation, Fungal
182 rdf:type schema:DefinedTerm
183 Ne31ed4e9189a4b80be5db74c330c1ce9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Genes, Fungal
185 rdf:type schema:DefinedTerm
186 Ne7e586c3a86a4093bcc5d4cee6150214 schema:issueNumber 5
187 rdf:type schema:PublicationIssue
188 Ned689c6be321425299e00c9e29f5ae24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Open Reading Frames
190 rdf:type schema:DefinedTerm
191 Nf003f37f4e734938b3265a45f65b68bc schema:name Laboratoire de Génétique Moléculaire, CNRS URA 1302, Ecole Normale Supérieure 46 rue d'Ulm, 75230, Paris Cedex 05, France
192 rdf:type schema:Organization
193 Nf28e4f2d11c34f7f8cd7ad4aec4eca0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name DNA-Binding Proteins
195 rdf:type schema:DefinedTerm
196 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
197 schema:name Biological Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
200 schema:name Genetics
201 rdf:type schema:DefinedTerm
202 sg:journal.1297380 schema:issn 1432-1874
203 1617-4615
204 schema:name Molecular Genetics and Genomics
205 rdf:type schema:Periodical
206 sg:person.01173021134.53 schema:affiliation Nf003f37f4e734938b3265a45f65b68bc
207 schema:familyName Delaveau
208 schema:givenName Thierry
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173021134.53
210 rdf:type schema:Person
211 sg:person.052027144.50 schema:affiliation https://www.grid.ac/institutes/grid.7634.6
212 schema:familyName Subik
213 schema:givenName Julius
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.052027144.50
215 rdf:type schema:Person
216 sg:person.0613241513.43 schema:affiliation N024ba285c0384caeb05e8701ddaeb2e5
217 schema:familyName Jacq
218 schema:givenName Claude
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613241513.43
220 rdf:type schema:Person
221 sg:person.0723636366.35 schema:affiliation N5b2ce07553194ba2a055e18ea6c0c903
222 schema:familyName Delahodde
223 schema:givenName Agnès
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723636366.35
225 rdf:type schema:Person
226 sg:person.07367311271.94 schema:affiliation https://www.grid.ac/institutes/grid.7942.8
227 schema:familyName Carvajal
228 schema:givenName Elvira
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07367311271.94
230 rdf:type schema:Person
231 sg:pub.10.1007/bf00260493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028865811
232 https://doi.org/10.1007/bf00260493
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/bf00277115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043029891
235 https://doi.org/10.1007/bf00277115
236 rdf:type schema:CreativeWork
237 sg:pub.10.1007/bf00317932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005780555
238 https://doi.org/10.1007/bf00317932
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/bf00351651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030044789
241 https://doi.org/10.1007/bf00351651
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/bf00410914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020400892
244 https://doi.org/10.1007/bf00410914
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/bf00419988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006707200
247 https://doi.org/10.1007/bf00419988
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/324407a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036417723
250 https://doi.org/10.1038/324407a0
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/340724a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021630509
253 https://doi.org/10.1038/340724a0
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/356408a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031743990
256 https://doi.org/10.1038/356408a0
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/356448a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037459102
259 https://doi.org/10.1038/356448a0
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1078400624 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1078442179 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1079679844 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1081686296 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1082743107 schema:CreativeWork
267 https://doi.org/10.1002/j.1460-2075.1990.tb07463.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078411349
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/yea.320070609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024309060
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/yea.320080909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029507758
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/0006-291x(74)90979-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013227521
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/0022-2836(88)90575-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015154338
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/0022-2836(89)90438-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015212318
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0092-8674(82)90211-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014139755
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/0092-8674(87)90081-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020523170
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/0092-8674(89)90063-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040690251
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/0092-8674(89)90606-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619589
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/0304-4165(91)90128-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037778234
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/0378-1119(87)90131-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001297840
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/0378-1119(91)90048-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1026537533
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0022-2836(84)80002-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030493170
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1073/pnas.74.12.5463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025360556
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.87.6.2077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033979305
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.89.20.9410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025200026
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/nar/15.13.5261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059931685
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/nar/15.19.7991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015748046
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1101/gad.6.1.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004700702
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1111/j.1432-1033.1977.tb11317.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013667036
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1111/j.1432-1033.1986.tb09640.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049550939
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1126/science.8346441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062654769
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1128/mcb.10.6.3194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006256200
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1128/mcb.11.1.476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051482968
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1128/mcb.11.11.5735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047275095
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1128/mcb.11.11.5746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041442446
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1128/mcb.11.5.2609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012398017
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1128/mcb.12.1.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025799673
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1128/mcb.12.4.1719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018992187
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1128/mcb.12.7.3006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002641408
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1128/mcb.13.1.462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032914730
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1128/mcb.13.7.3872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012997371
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1128/mcb.7.3.1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006310600
334 rdf:type schema:CreativeWork
335 https://www.grid.ac/institutes/grid.7634.6 schema:alternateName Comenius University
336 schema:name Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Mlynska dolina B2, 842 15, Bratislava, Slovak Republic
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.7942.8 schema:alternateName Université Catholique de Louvain
339 schema:name Unite de Biochimie Physiologique, Université de Louvain, Place Croix du Sud, 2-20, B-1348, Louvain-La-Neuve, Belgium
340 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...