A novel cardiac potassium channel that is active and conductive at depolarized potentials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-12

AUTHORS

David T. Yue, Eduardo Marban

ABSTRACT

We report the existence of a novel potassium channel revealed in single-channel recordings from guinea-pig ventricular heart cells. The channel, observed in ∼10% of patches, demonstrates a 14 pS conductance at physiological potassium concentrations, does not rectify over the voltage range of the action potential, and is quite selective for K ions. The channel activates with depolarization, but does not require intracellular Ca2+ ions to open. Open channel probability increases rapidly (<10 ms) to a plateau in response to depolarizing voltage steps, and demonstrates no detectable inactivation (>600 ms). These features clearly distinguish this channel from other known K channels in cardiac muscle. Because of its high activity at plateau potentials, we propose the nameiKp. More... »

PAGES

127-133

References to SciGraph publications

  • 1981-06. Ca-dependent K channels with large unitary conductance in chromaffin cell membranes in NATURE
  • 1983. Fitting and Statistical Analysis of Single-Channel Records in SINGLE-CHANNEL RECORDING
  • 1987-12. An analysis of the delayed outward current in single ventricular cells of the guinea-pig in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1982-03. Single Ca2+-activated nonselective cation channels in neuroblastoma in NATURE
  • 1983-09. ATP-regulated K+ channels in cardiac muscle in NATURE
  • 1986-04. Existence of a calcium-dependent potassium channel in the membrane of cow cardiac Purkinje cells in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1984-05. Intracellular Na+ activates a K+ channel in mammalian cardiac cells in NATURE
  • 1984-06. Inward-rectifying channels in isolated patches of the heart cell membrane: ATP-dependence and comparison with cell-attached patches in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1987-01. Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+ in NATURE
  • 1981-08. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1982-08. Detection of K+ and Cl− channels from calf cardiac sarcolemma in planar lipid bilayer membranes in NATURE
  • 1987-12. Potassium currents in cardiac cells in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1987-09. Catecholamines modulate the delayed rectifying potassium current (IK) in guinea pig ventricular myocytes in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1987-08. Two types of transient outward currents in cardiac ventricular cells of mice in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1983. The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms in SINGLE-CHANNEL RECORDING
  • 1985-10. Phosphorylation of Ion channels in THE JOURNAL OF MEMBRANE BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00582522

    DOI

    http://dx.doi.org/10.1007/bf00582522

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032989593

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3217234


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