Type 1 diabetes mellitus: an imbalance between effector and regulatory T cells? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-06

AUTHORS

E. J. Rashba, E. -P. Reich, C. A. Janeway, R. S. Sherwin

ABSTRACT

Abundant evidence now exists that autoimmunity plays a critical role in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus. The non-obese diabetic (NOD) mouse is an extensively studied animal model of this T-cell-mediated autoimmune disease. Our laboratory has focused on isolating diabetogenic T cell clones from NOD mice as a means of elucidating the pathogenesis of type 1 diabetes. This experimental approach presupposes that type 1 diabetes in NOD mice results from the action of islet-reactive T cells that are not present in other mouse strains; the diabetogenic T cells would therefore represent "forbidden clones" which exist in NOD mice as a result of a failure of clonal deletion. While the inappropriate presence of diabetogenic T cells probably plays a central role in murine diabetes, it cannot explain all aspects of the disease. Type 1 diabetes is a chronic disorder with a lengthy preclinical stage; if the diabetogenic T cells acted in an unopposed fashion, one might expect to see a much more fulminant clinical course. This observation suggests that regulatory influences are likely to exist in this disease--a possibility supported by recent experimental data. If these regulatory influences could be identified and enhanced, specific immunotherapy for type 1 diabetes could be achieved. More... »

PAGES

61-69

References to SciGraph publications

  • 1989-10. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis in NATURE
  • 1989-09. An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes in NATURE
  • 1987-07. Prevention of autoimmune insulitis by expression of I–E molecules in NOD mice in NATURE
  • 1991-09. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1 in NATURE
  • 1990-09. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase in NATURE
  • 1988-04. The cataract Shionogi mouse, a sister strain of the non-obese diabetic mouse: similar class II but different class I gene products in DIABETOLOGIA
  • 1983-04. The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association in DIABETOLOGIA
  • 1988-01. Dietary prevention of diabetes in the non-obese diabetic mouse in DIABETOLOGIA
  • 1984-12. Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide in DIABETOLOGIA
  • 1984-11. Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus in JOURNAL OF CLINICAL IMMUNOLOGY
  • 1991-09. Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice in NATURE
  • 1990-06. Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice in NATURE
  • 1990-06. Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain in NATURE
  • 1986-04. Preventive effects of Cyclosporin on diabetes in NOD mice in DIABETOLOGIA
  • 1990-06. Prevention of diabetes in non-obese diabetic I-Ak transgenic mice in NATURE
  • 1987-10. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00578215

    DOI

    http://dx.doi.org/10.1007/bf00578215

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049518507

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8219259


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