Human growth hormone in delayed union and non-union of fractures View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-12

AUTHORS

Erkki V. S. Koskinen, Ralf V. Lindholm, Raimo A. Nieminen, Jaakko P. Puranen, Uljas Attila

ABSTRACT

1. Human growth hormone (HGH) was administered to a series of 20 adult patients admitted to hospital because of delayed union or non-union of a fracture of a long bone. They included 15 tibial shaft fractures and other bone lesions with a poor prognosis for consolidation. Their progress was studied and compared with suitable controls. 2. Bone union occurred in all 20 patients and the time required for stabilization was 8 weeks or less in 12 cases, and 12 weeks or less in 17 cases (60% and 85% of the series respectively). No excessive callus formation was observed. 3. Several metabolic parameters indicative of active bone metabolism showed an increase from the start of HGH treatment up to 3 weeks, followed by either decline or a constant up to 5 weeks. 4. The endogenous serum HGH level was strikingly low and presented a negative correlation with the consolidation time. The rapid consolidation of the fractures suggested that HGH therapy has a bone union promoting effect. More... »

PAGES

317-322

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00572258

DOI

http://dx.doi.org/10.1007/bf00572258

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042054554


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Clinic for Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koskinen", 
        "givenName": "Erkki V. S.", 
        "id": "sg:person.052257734.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.052257734.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Clinic for Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindholm", 
        "givenName": "Ralf V.", 
        "id": "sg:person.074637150.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074637150.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Clinic for Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nieminen", 
        "givenName": "Raimo A.", 
        "id": "sg:person.0113761066.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113761066.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Clinic for Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Puranen", 
        "givenName": "Jaakko P.", 
        "id": "sg:person.0112117671.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0112117671.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Clinic for Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Attila", 
        "givenName": "Uljas", 
        "id": "sg:person.076241626.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.076241626.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3109/17453676708989622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021482520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1952.01260010459004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042565822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/ort.1963.34.suppl-62.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043527639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/ort.1970.41.suppl-135.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048683188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197101000-00027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060155661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197101000-00027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060155661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197101000-00027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060155661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197209000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060156177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197209000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060156177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-197209000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060156177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-196345060-00018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068883684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2106/00004623-196648020-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068884169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.40b1.42", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075797211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076043837", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076154907", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076345266", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080659235", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/0301-620x.46b3.373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101155375"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1978-12", 
    "datePublishedReg": "1978-12-01", 
    "description": "1. Human growth hormone (HGH) was administered to a series of 20 adult patients admitted to hospital because of delayed union or non-union of a fracture of a long bone. They included 15 tibial shaft fractures and other bone lesions with a poor prognosis for consolidation. Their progress was studied and compared with suitable controls. 2. Bone union occurred in all 20 patients and the time required for stabilization was 8 weeks or less in 12 cases, and 12 weeks or less in 17 cases (60% and 85% of the series respectively). No excessive callus formation was observed. 3. Several metabolic parameters indicative of active bone metabolism showed an increase from the start of HGH treatment up to 3 weeks, followed by either decline or a constant up to 5 weeks. 4. The endogenous serum HGH level was strikingly low and presented a negative correlation with the consolidation time. The rapid consolidation of the fractures suggested that HGH therapy has a bone union promoting effect.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00572258", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1086603", 
        "issn": [
          "0341-2695", 
          "1432-5195"
        ], 
        "name": "International Orthopaedics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Human growth hormone in delayed union and non-union of fractures", 
    "pagination": "317-322", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00572258"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c853a6d24fb440a97d15ad7584e1aa70af2f8d292e80e2df87015331eb971ec8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042054554"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00572258", 
      "https://app.dimensions.ai/details/publication/pub.1042054554"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91441_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00572258"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00572258'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00572258'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00572258'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00572258'


 

This table displays all metadata directly associated to this object as RDF triples.

127 TRIPLES      21 PREDICATES      41 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00572258 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N90c9b410ed4c4adb88d7a94c099f7da1
4 schema:citation https://app.dimensions.ai/details/publication/pub.1076043837
5 https://app.dimensions.ai/details/publication/pub.1076154907
6 https://app.dimensions.ai/details/publication/pub.1076345266
7 https://app.dimensions.ai/details/publication/pub.1080659235
8 https://doi.org/10.1001/archsurg.1952.01260010459004
9 https://doi.org/10.1097/00003086-197101000-00027
10 https://doi.org/10.1097/00003086-197209000-00014
11 https://doi.org/10.1302/0301-620x.40b1.42
12 https://doi.org/10.1302/0301-620x.46b3.373
13 https://doi.org/10.2106/00004623-196345060-00018
14 https://doi.org/10.2106/00004623-196648020-00004
15 https://doi.org/10.3109/17453676708989622
16 https://doi.org/10.3109/ort.1963.34.suppl-62.01
17 https://doi.org/10.3109/ort.1970.41.suppl-135.01
18 schema:datePublished 1978-12
19 schema:datePublishedReg 1978-12-01
20 schema:description 1. Human growth hormone (HGH) was administered to a series of 20 adult patients admitted to hospital because of delayed union or non-union of a fracture of a long bone. They included 15 tibial shaft fractures and other bone lesions with a poor prognosis for consolidation. Their progress was studied and compared with suitable controls. 2. Bone union occurred in all 20 patients and the time required for stabilization was 8 weeks or less in 12 cases, and 12 weeks or less in 17 cases (60% and 85% of the series respectively). No excessive callus formation was observed. 3. Several metabolic parameters indicative of active bone metabolism showed an increase from the start of HGH treatment up to 3 weeks, followed by either decline or a constant up to 5 weeks. 4. The endogenous serum HGH level was strikingly low and presented a negative correlation with the consolidation time. The rapid consolidation of the fractures suggested that HGH therapy has a bone union promoting effect.
21 schema:genre research_article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf N4407663dd0444697ad90fa673b68ea19
25 N9b8247b466cb416ebb06fc0fcad051b4
26 sg:journal.1086603
27 schema:name Human growth hormone in delayed union and non-union of fractures
28 schema:pagination 317-322
29 schema:productId N2382cc740b3d4bec81aaede9a5759de5
30 N5388aca94d7a47a09d604ca636106b8d
31 Nebdabd189d094762815b6a2825b9daf5
32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042054554
33 https://doi.org/10.1007/bf00572258
34 schema:sdDatePublished 2019-04-15T09:00
35 schema:sdLicense https://scigraph.springernature.com/explorer/license/
36 schema:sdPublisher N1415f39ff1cf4480b54e313203bd5afa
37 schema:url http://link.springer.com/10.1007/BF00572258
38 sgo:license sg:explorer/license/
39 sgo:sdDataset articles
40 rdf:type schema:ScholarlyArticle
41 N1415f39ff1cf4480b54e313203bd5afa schema:name Springer Nature - SN SciGraph project
42 rdf:type schema:Organization
43 N2382cc740b3d4bec81aaede9a5759de5 schema:name dimensions_id
44 schema:value pub.1042054554
45 rdf:type schema:PropertyValue
46 N4407663dd0444697ad90fa673b68ea19 schema:volumeNumber 1
47 rdf:type schema:PublicationVolume
48 N5388aca94d7a47a09d604ca636106b8d schema:name doi
49 schema:value 10.1007/bf00572258
50 rdf:type schema:PropertyValue
51 N65bf6335160b49d6b011665fd4a2d67d rdf:first sg:person.074637150.00
52 rdf:rest N95065593022945f88ba12a9c66b9cc2d
53 N77611e418eb84fffb7a4137180699991 rdf:first sg:person.076241626.50
54 rdf:rest rdf:nil
55 N90c9b410ed4c4adb88d7a94c099f7da1 rdf:first sg:person.052257734.07
56 rdf:rest N65bf6335160b49d6b011665fd4a2d67d
57 N95065593022945f88ba12a9c66b9cc2d rdf:first sg:person.0113761066.37
58 rdf:rest Nd8345b70e91349ef9baf8f0fa7bde647
59 N9b8247b466cb416ebb06fc0fcad051b4 schema:issueNumber 4
60 rdf:type schema:PublicationIssue
61 Nd8345b70e91349ef9baf8f0fa7bde647 rdf:first sg:person.0112117671.59
62 rdf:rest N77611e418eb84fffb7a4137180699991
63 Nebdabd189d094762815b6a2825b9daf5 schema:name readcube_id
64 schema:value c853a6d24fb440a97d15ad7584e1aa70af2f8d292e80e2df87015331eb971ec8
65 rdf:type schema:PropertyValue
66 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
67 schema:name Medical and Health Sciences
68 rdf:type schema:DefinedTerm
69 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
70 schema:name Clinical Sciences
71 rdf:type schema:DefinedTerm
72 sg:journal.1086603 schema:issn 0341-2695
73 1432-5195
74 schema:name International Orthopaedics
75 rdf:type schema:Periodical
76 sg:person.0112117671.59 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
77 schema:familyName Puranen
78 schema:givenName Jaakko P.
79 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0112117671.59
80 rdf:type schema:Person
81 sg:person.0113761066.37 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
82 schema:familyName Nieminen
83 schema:givenName Raimo A.
84 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0113761066.37
85 rdf:type schema:Person
86 sg:person.052257734.07 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
87 schema:familyName Koskinen
88 schema:givenName Erkki V. S.
89 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.052257734.07
90 rdf:type schema:Person
91 sg:person.074637150.00 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
92 schema:familyName Lindholm
93 schema:givenName Ralf V.
94 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074637150.00
95 rdf:type schema:Person
96 sg:person.076241626.50 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
97 schema:familyName Attila
98 schema:givenName Uljas
99 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.076241626.50
100 rdf:type schema:Person
101 https://app.dimensions.ai/details/publication/pub.1076043837 schema:CreativeWork
102 https://app.dimensions.ai/details/publication/pub.1076154907 schema:CreativeWork
103 https://app.dimensions.ai/details/publication/pub.1076345266 schema:CreativeWork
104 https://app.dimensions.ai/details/publication/pub.1080659235 schema:CreativeWork
105 https://doi.org/10.1001/archsurg.1952.01260010459004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042565822
106 rdf:type schema:CreativeWork
107 https://doi.org/10.1097/00003086-197101000-00027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060155661
108 rdf:type schema:CreativeWork
109 https://doi.org/10.1097/00003086-197209000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060156177
110 rdf:type schema:CreativeWork
111 https://doi.org/10.1302/0301-620x.40b1.42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075797211
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1302/0301-620x.46b3.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101155375
114 rdf:type schema:CreativeWork
115 https://doi.org/10.2106/00004623-196345060-00018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068883684
116 rdf:type schema:CreativeWork
117 https://doi.org/10.2106/00004623-196648020-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068884169
118 rdf:type schema:CreativeWork
119 https://doi.org/10.3109/17453676708989622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021482520
120 rdf:type schema:CreativeWork
121 https://doi.org/10.3109/ort.1963.34.suppl-62.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043527639
122 rdf:type schema:CreativeWork
123 https://doi.org/10.3109/ort.1970.41.suppl-135.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048683188
124 rdf:type schema:CreativeWork
125 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
126 schema:name Clinic for Orthopaedics and Traumatology, University of Helsinki, Helsinki, Finland
127 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...