Altered frequency of initiation sites of DNA replication in Werner's syndrome cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-12

AUTHORS

Fujio Takeuchi, Fumio Hanaoka, Makoto Goto, Ieo Akaoka, Tada-aki Hori, Masa-atsu Yamada, Terumasa Miyamoto

ABSTRACT

DNA replication of cultured fibroblasts of early passage derived from Werner's syndrome (adult progeria) patients and from normal subjects were compared by DNA fiber autoradiography. The frequency of replication initiation was decreased in Werner's syndrome cells derived from five patients compared with that in normal cells derived from three persons of different ages. The rate of DNA chain elongation did not differ between Werner's syndrome cells and normal cells. More... »

PAGES

365-368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00569220

DOI

http://dx.doi.org/10.1007/bf00569220

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002634303

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7106772


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