Effect of particle size on the bioavailability of digoxin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1975-09

AUTHORS

A. J. Jounela, P. J. Pentikäinen, A. Sothmann

ABSTRACT

The bioavailability of digoxin in three tablets prepared from materials with different particle sizes was measured in healthy volunteers in a cross-over study using an alcoholic solution of digoxin as a reference standard. Its bioavailability in tablets with particle sizes of 7 mu or 13 mu was 78-97% of that of digoxin in solution. The tablet with largest particle size (102 mu) showed markedly lower bioavailability than the reference solution, namely 39%. It is obvious that particle size is an important determinant of the dissolution rate and bioavailability of digoxin. More... »

PAGES

365-370

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00562664

DOI

http://dx.doi.org/10.1007/bf00562664

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044388678

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1233237


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