Bioavailability and pharmacokinetics of oxazepam View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-07

AUTHORS

J. Sonne, S. Loft, M. Døssing, A. Vollmer-Larsen, K. L. Olesen, M. Victor, F. Andreasen, P. B. Andreasen

ABSTRACT

Six healthy volunteers received oxazepam 15 mg i.v. and orally at an interval of at least one week. The kinetic variables of i.v. oxazepam were: elimination half-life (t1/2 beta) 6.7 h, total clearance (CL) 1.07 ml.min-1.kg-1, volume of distribution (Vc) 0.27 l.kg-1 (0.21-0.49) and volume of distribution at steady-state (Vss) 0.59 l.kg-1. The intravenous disposition of unbound oxazepam was characterized by a clearance of 22.5 ml.min-1.kg-1 and a distribution volume of 12.3 l.kg-1. After oral oxazepam the peak plasma level was reached in 1.7 to 2.8 h. The plasma t1/2 beta at 5.8 h was not significantly different from the i.v. value. Absorption was almost complete, with a bioavailability of 92.8%. Urinary recovery was 80.0 and 71.4% of the dose after intravenous and oral administration, respectively. Renal clearance (CLR) of the glucuronide metabolite was 1.10 ml.min-1.kg-1 (0.98-1.52). Oxazepam was extensively bound to plasma protein with a free fraction of 4.5%. More... »

PAGES

385-389

References to SciGraph publications

  • 1974-05. Effects of different rates of absorption of two benzodiazepins on subjective and objective parameters in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1981-08. Disposition of oxazepam in relation to age, sex, and cigarette smoking in JOURNAL OF MOLECULAR MEDICINE
  • 1981-12. Renal disease, age, and oxazepam kinetics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1981-04. Clinical Pharmacokinetics of Oxazepam and Lorazepam in CLINICAL PHARMACOKINETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00561369

    DOI

    http://dx.doi.org/10.1007/bf00561369

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024268876

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3197746


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