Pharmacokinetics of intravenous captopril in healthy men View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-07

AUTHORS

W. A. Creasey, R. A. Morrison, S. M. Singhvi, D. A. Willard

ABSTRACT

The pharmacokinetic characteristics of intravenously-administered captopril were investigated in 7 healthy men 20 to 33 years old. Capropril, labeled with 14C, was given by injection over a 1 min period at mean doses of 2.78 mg (13.8 microCi), 5.67 mg (28.2 microCi) and 11.4 mg (56.8 microCi). Concentrations of unchanged captopril, captopril disulfide, and other metabolites (collectively) were determined in body fluids. Pharmacokinetic parameters were calculated for unchanged captopril, and it was shown that the disposition of intravenously-administered drug was linear with respect to dose over the dosage range studied. More... »

PAGES

367-370

References to SciGraph publications

  • 1980-05. Disposition of captopril in normal subjects in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1978-02. A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximation in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
  • 1982-04. Captopril kinetics in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00561366

    DOI

    http://dx.doi.org/10.1007/bf00561366

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030895907

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3058486


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