The relationship between theophylline clearance and age in adult life View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-01

AUTHORS

S. H. D. Jackson, A. Johnston, R. Woollard, P. Turner

ABSTRACT

Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline.Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age.Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades. More... »

PAGES

29-34

References to SciGraph publications

  • 1980-10. Effect of age on patterns of theophylline metabolism in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1985-03. The relationship between clearance of theophylline and age within the adult age range in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1985-04. Theophylline kinetics in chronic obstructive airway disease in the elderly in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1983-07. Theophylline kinetics in a geriatric group in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00561019

    DOI

    http://dx.doi.org/10.1007/bf00561019

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017264006

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2917585


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Asthma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Half-Life", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metabolic Clearance Rate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Theophylline", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.416353.6", 
              "name": [
                "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jackson", 
            "givenName": "S. H. D.", 
            "id": "sg:person.015525260622.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015525260622.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.416353.6", 
              "name": [
                "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnston", 
            "givenName": "A.", 
            "id": "sg:person.01224331407.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224331407.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.416353.6", 
              "name": [
                "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Woollard", 
            "givenName": "R.", 
            "id": "sg:person.01265242221.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265242221.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK", 
              "id": "http://www.grid.ac/institutes/grid.416353.6", 
              "name": [
                "Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turner", 
            "givenName": "P.", 
            "id": "sg:person.01230760471.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230760471.16"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/clpt.1985.74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050157280", 
              "https://doi.org/10.1038/clpt.1985.74"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.1980.188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039184626", 
              "https://doi.org/10.1038/clpt.1980.188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.1983.130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053130978", 
              "https://doi.org/10.1038/clpt.1983.130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00547418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039522721", 
              "https://doi.org/10.1007/bf00547418"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1989-01", 
        "datePublishedReg": "1989-01-01", 
        "description": "Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline.Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age.Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/bf00561019", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1054337", 
            "issn": [
              "0031-6970", 
              "1432-1041"
            ], 
            "name": "European Journal of Clinical Pharmacology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "keywords": [
          "theophylline clearance", 
          "adult life", 
          "volume of distribution", 
          "late adult life", 
          "young adult life", 
          "high clearance values", 
          "terminal elimination", 
          "mean clearance", 
          "ninth decade", 
          "combined group", 
          "oldest third", 
          "lower clearance", 
          "clearance values", 
          "clearance", 
          "age", 
          "min/", 
          "significant age", 
          "volunteers", 
          "patients", 
          "group", 
          "life", 
          "t1/2", 
          "subjects", 
          "third", 
          "years", 
          "fall", 
          "elimination", 
          "volume", 
          "changes", 
          "relationship", 
          "CBW", 
          "decades", 
          "values", 
          "distribution"
        ], 
        "name": "The relationship between theophylline clearance and age in adult life", 
        "pagination": "29-34", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1017264006"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/bf00561019"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "2917585"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/bf00561019", 
          "https://app.dimensions.ai/details/publication/pub.1017264006"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_188.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/bf00561019"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00561019'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00561019'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00561019'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00561019'


     

    This table displays all metadata directly associated to this object as RDF triples.

    180 TRIPLES      21 PREDICATES      76 URIs      64 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/bf00561019 schema:about N0a59ced9878b44f0a41cadd108cb6ba6
    2 N341473e9a40e477b81dff1043b7fbcbe
    3 N43e0a65df38148d7b0c59f339b2afe4a
    4 N6e6aaa23edf940c897eead3389c0a476
    5 N7a109981327447e2aeb748597701bb87
    6 N92e8e29d935944b7a0dd2ebf196235fa
    7 Na127e1dc798c470d809d1b4b10895ff2
    8 Nc3bc95dedc2a4da1b5b970bcfdf539b3
    9 Nc92708054acf47a6aa4c2d94fa65f8e9
    10 Ne26b27b3d0ab4db2bbaf707ed973243f
    11 Ne4102db091e34844963dd1edee17ca04
    12 Nf4e1e3385fb740c8b24ed2f03a243c3e
    13 anzsrc-for:11
    14 anzsrc-for:1103
    15 schema:author N4c0216bb69724d0c89e5daff17eabf2a
    16 schema:citation sg:pub.10.1007/bf00547418
    17 sg:pub.10.1038/clpt.1980.188
    18 sg:pub.10.1038/clpt.1983.130
    19 sg:pub.10.1038/clpt.1985.74
    20 schema:datePublished 1989-01
    21 schema:datePublishedReg 1989-01-01
    22 schema:description Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured. Volume of distribution (V) and terminal elimination half-life (t1/2) were also calculated in the volunteers who received i.v. theophylline.Although patients tended to have higher clearance values than volunteers, in both groups the oldest third had the lowest clearances. For the combined group (corrected for the patient effect) the oldest third (mean age 70 years) had a mean clearance of 0.53 versus 0.72 for the middle third (mean age 47 years) and 0.73 ml/min/kg CBW for the youngest third (mean age 26 years). There was no statistically significant age related change in V/kg CBW but t1/2 did rise with increasing age.Thus, although clearance does not fall with increasing age during younger adult life, there is a fall during late adult life becoming apparent in the seventh, eighth and ninth decades.
    23 schema:genre article
    24 schema:isAccessibleForFree false
    25 schema:isPartOf N6d800ea3adff45778d4806589e64bb00
    26 N831bf88910d947adad56d2d132d9640a
    27 sg:journal.1054337
    28 schema:keywords CBW
    29 adult life
    30 age
    31 changes
    32 clearance
    33 clearance values
    34 combined group
    35 decades
    36 distribution
    37 elimination
    38 fall
    39 group
    40 high clearance values
    41 late adult life
    42 life
    43 lower clearance
    44 mean clearance
    45 min/
    46 ninth decade
    47 oldest third
    48 patients
    49 relationship
    50 significant age
    51 subjects
    52 t1/2
    53 terminal elimination
    54 theophylline clearance
    55 third
    56 values
    57 volume
    58 volume of distribution
    59 volunteers
    60 years
    61 young adult life
    62 schema:name The relationship between theophylline clearance and age in adult life
    63 schema:pagination 29-34
    64 schema:productId Nd8bfcaf975524e0cb41646ec29c1585e
    65 Ne5e10fb9fd7e41cd9a21f4d12c5d93f4
    66 Nf83282b0a9ee462c82201af67dcc7280
    67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017264006
    68 https://doi.org/10.1007/bf00561019
    69 schema:sdDatePublished 2022-09-02T15:45
    70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    71 schema:sdPublisher N128fb30808d14d70945f654265087e29
    72 schema:url https://doi.org/10.1007/bf00561019
    73 sgo:license sg:explorer/license/
    74 sgo:sdDataset articles
    75 rdf:type schema:ScholarlyArticle
    76 N0a59ced9878b44f0a41cadd108cb6ba6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Metabolic Clearance Rate
    78 rdf:type schema:DefinedTerm
    79 N128fb30808d14d70945f654265087e29 schema:name Springer Nature - SN SciGraph project
    80 rdf:type schema:Organization
    81 N341473e9a40e477b81dff1043b7fbcbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    82 schema:name Asthma
    83 rdf:type schema:DefinedTerm
    84 N43e0a65df38148d7b0c59f339b2afe4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Middle Aged
    86 rdf:type schema:DefinedTerm
    87 N4b680c2c9c2e4f6e947268ab636d5b25 rdf:first sg:person.01224331407.87
    88 rdf:rest Nc73a234239304325b42bb88b106b5299
    89 N4c0216bb69724d0c89e5daff17eabf2a rdf:first sg:person.015525260622.90
    90 rdf:rest N4b680c2c9c2e4f6e947268ab636d5b25
    91 N6d800ea3adff45778d4806589e64bb00 schema:volumeNumber 36
    92 rdf:type schema:PublicationVolume
    93 N6e6aaa23edf940c897eead3389c0a476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Half-Life
    95 rdf:type schema:DefinedTerm
    96 N7a109981327447e2aeb748597701bb87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Aged, 80 and over
    98 rdf:type schema:DefinedTerm
    99 N831bf88910d947adad56d2d132d9640a schema:issueNumber 1
    100 rdf:type schema:PublicationIssue
    101 N92e8e29d935944b7a0dd2ebf196235fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Humans
    103 rdf:type schema:DefinedTerm
    104 Na127e1dc798c470d809d1b4b10895ff2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Aged
    106 rdf:type schema:DefinedTerm
    107 Nc3bc95dedc2a4da1b5b970bcfdf539b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Female
    109 rdf:type schema:DefinedTerm
    110 Nc73a234239304325b42bb88b106b5299 rdf:first sg:person.01265242221.30
    111 rdf:rest Nfb9b2c2f40cc4acc908de192bc5ac32b
    112 Nc92708054acf47a6aa4c2d94fa65f8e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Theophylline
    114 rdf:type schema:DefinedTerm
    115 Nd8bfcaf975524e0cb41646ec29c1585e schema:name pubmed_id
    116 schema:value 2917585
    117 rdf:type schema:PropertyValue
    118 Ne26b27b3d0ab4db2bbaf707ed973243f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Adult
    120 rdf:type schema:DefinedTerm
    121 Ne4102db091e34844963dd1edee17ca04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Aging
    123 rdf:type schema:DefinedTerm
    124 Ne5e10fb9fd7e41cd9a21f4d12c5d93f4 schema:name dimensions_id
    125 schema:value pub.1017264006
    126 rdf:type schema:PropertyValue
    127 Nf4e1e3385fb740c8b24ed2f03a243c3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Male
    129 rdf:type schema:DefinedTerm
    130 Nf83282b0a9ee462c82201af67dcc7280 schema:name doi
    131 schema:value 10.1007/bf00561019
    132 rdf:type schema:PropertyValue
    133 Nfb9b2c2f40cc4acc908de192bc5ac32b rdf:first sg:person.01230760471.16
    134 rdf:rest rdf:nil
    135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    136 schema:name Medical and Health Sciences
    137 rdf:type schema:DefinedTerm
    138 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    139 schema:name Clinical Sciences
    140 rdf:type schema:DefinedTerm
    141 sg:journal.1054337 schema:issn 0031-6970
    142 1432-1041
    143 schema:name European Journal of Clinical Pharmacology
    144 schema:publisher Springer Nature
    145 rdf:type schema:Periodical
    146 sg:person.01224331407.87 schema:affiliation grid-institutes:grid.416353.6
    147 schema:familyName Johnston
    148 schema:givenName A.
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224331407.87
    150 rdf:type schema:Person
    151 sg:person.01230760471.16 schema:affiliation grid-institutes:grid.416353.6
    152 schema:familyName Turner
    153 schema:givenName P.
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230760471.16
    155 rdf:type schema:Person
    156 sg:person.01265242221.30 schema:affiliation grid-institutes:grid.416353.6
    157 schema:familyName Woollard
    158 schema:givenName R.
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265242221.30
    160 rdf:type schema:Person
    161 sg:person.015525260622.90 schema:affiliation grid-institutes:grid.416353.6
    162 schema:familyName Jackson
    163 schema:givenName S. H. D.
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015525260622.90
    165 rdf:type schema:Person
    166 sg:pub.10.1007/bf00547418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039522721
    167 https://doi.org/10.1007/bf00547418
    168 rdf:type schema:CreativeWork
    169 sg:pub.10.1038/clpt.1980.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039184626
    170 https://doi.org/10.1038/clpt.1980.188
    171 rdf:type schema:CreativeWork
    172 sg:pub.10.1038/clpt.1983.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053130978
    173 https://doi.org/10.1038/clpt.1983.130
    174 rdf:type schema:CreativeWork
    175 sg:pub.10.1038/clpt.1985.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050157280
    176 https://doi.org/10.1038/clpt.1985.74
    177 rdf:type schema:CreativeWork
    178 grid-institutes:grid.416353.6 schema:alternateName Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK
    179 schema:name Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK
    180 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...