Almitrine bismesylate disposition in the human digestive tract View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-09

AUTHORS

N. Vidon, S. Chaussade, J. Ph. Jeanniot, B. Huchet, C. Franchisseur, J. J. Bernier

ABSTRACT

The absorption of almitrine from the upper gastrointestinal tract has been evaluated in 6 healthy volunteers by an intubation technique. Almitrine bismesylate dissolved in malic acid was introduced into the stomach after homogenization with a meal containing the marker 14C-polyethylene glycol (PEG) 4000. Unlabeled PEG 4000 was infused into the second part of duodenum throughout the experiment. Samples of the luminal content were collected every 15 min for four hours from the stomach and at the ligament of Treitz. Blood was also collected. Almitrine was neither absorbed from nor metabolized in the stomach. About 37% of the quantity of drug emptied from the stomach was absorbed from the duodenum. Almitrine was detected in plasma 50 min after ingestion of the meal and its plasma concentration-time profile reflected the cumulative gastric emptying rate. The metabolite tetrahydroxy almitrine was found in intestinal samples as soon as unchanged drug was detected in plasma. The intraluminal rate of formation of the metabolite increased with time. The results suggest hepatic metabolism of almitrine followed by rapid excretion of the metabolite in the bile. More... »

PAGES

487-491

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00558129

DOI

http://dx.doi.org/10.1007/bf00558129

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003049779

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2598987


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158 rdf:type schema:Organization
 




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