Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-01

AUTHORS

J. Sonne, H. Enghusen Poulsen, S. Loft, M. Døssing, A. Vollmer-Larsen, K. Simonsen, H. Thyssen, K. Lundstrøm

ABSTRACT

In nine healthy volunteers, the clearance and metabolism of acetaminophen 1000 mg i.v. was evaluated with and without two concomitant oral doses of codeine in order to investigate a possible interaction. Plasma acetaminophen was followed for 720 min and urine was collected for 24 h after each dose for determination of metabolites. When codeine was coadministered, the average total clearance of acetaminophen and its clearance by glucuronidation, sulphation and mercapturate formation were 0.58 to 1.12-times the control values. It is concluded that therapeutic doses of codeine do not influence the clearance or metabolism of acetaminophen. More... »

PAGES

109-111

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00555519

DOI

http://dx.doi.org/10.1007/bf00555519

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023718277

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3220092


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