Diffusion of intramuscular ketoprofen into the cerebrospinal fluid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-05

AUTHORS

P. Netter, F. Lapicque, B. Bannwarth, J. N. Tamisier, P. Thomas, R. J. Royer

ABSTRACT

Serum and cerebrospinal fluid (CSF) concentrations of ketoprofen have been measured in 36 patients hospitalised for sciatica. Diagnostic lumbar puncture was done 15 min to 13 h after a single 100 mg intramuscular dose of ketoprofen. Serum and CSF were sampled at the same time. Free serum concentrations were determined by equilibrium dialysis. Total and free concentrations were assayed by a highly sensitive and specific HPLC method. Ketoprofen rapidly crossed the blood-brain barrier and was detected in CSF 15 min after its administration. The rapid diffusion can be explained by the high lipid solubility of the drug. The CSF level was in equilibrium with the free serum concentration from the second to the 13th hours. More... »

PAGES

319-321

References to SciGraph publications

  • 1983-01. Diffusion of oxyphenbutazone into synovial fluid, synovial tissue, joint cartilage and cerebrospinal fluid in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
  • 1982-08. Clinical Pharmacokinetics of Cerebrospinal Fluid in CLINICAL PHARMACOKINETICS
  • 1982-09. Central nervous system effects of aspirin in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 1983-08. Clinical Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs in CLINICAL PHARMACOKINETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00544088

    DOI

    http://dx.doi.org/10.1007/bf00544088

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049763813

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/4076328


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