The effect of alinidine (St 567) on emotionally induced tachycardia in man View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-11

AUTHORS

J. Auböck, H. Konzett, E. Olbrich

ABSTRACT

Experiments were performed in a randomized double blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally — induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine. More... »

PAGES

467-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00542040

DOI

http://dx.doi.org/10.1007/bf00542040

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023636187

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7075652


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clonidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Evaluation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stress, Psychological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tachycardia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University of Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5771.4", 
          "name": [
            "Department of Pharmacology, University of Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aub\u00f6ck", 
        "givenName": "J.", 
        "id": "sg:person.01121360562.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121360562.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, University of Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5771.4", 
          "name": [
            "Department of Pharmacology, University of Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konzett", 
        "givenName": "H.", 
        "id": "sg:person.050701730.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.050701730.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biostatistics and Documentation, University of Innsbruck, Austria", 
          "id": "http://www.grid.ac/institutes/grid.5771.4", 
          "name": [
            "Department of Biostatistics and Documentation, University of Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olbrich", 
        "givenName": "E.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00563551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031317437", 
          "https://doi.org/10.1007/bf00563551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00507111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000492242", 
          "https://doi.org/10.1007/bf00507111"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1982-11", 
    "datePublishedReg": "1982-11-01", 
    "description": "Experiments were performed in a randomized double blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally \u2014 induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00542040", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1054337", 
        "issn": [
          "0031-6970", 
          "1432-1041"
        ], 
        "name": "European Journal of Clinical Pharmacology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "randomized double-blind cross-over study", 
      "double-blind cross-over study", 
      "blind cross-over study", 
      "effect of alinidine", 
      "forearm blood flow", 
      "diastolic blood pressure", 
      "cross-over study", 
      "bradycardic effects", 
      "blood pressure", 
      "sinus node", 
      "healthy volunteers", 
      "blood flow", 
      "alinidine", 
      "tachycardia", 
      "concomitant rise", 
      "clonidine", 
      "mental tasks", 
      "new analogues", 
      "volunteers", 
      "men", 
      "effect", 
      "study", 
      "pressure", 
      "analogues", 
      "stress", 
      "nodes", 
      "rise", 
      "questions", 
      "task", 
      "flow", 
      "experiments", 
      "efficiency"
    ], 
    "name": "The effect of alinidine (St 567) on emotionally induced tachycardia in man", 
    "pagination": "467-471", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023636187"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00542040"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7075652"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00542040", 
      "https://app.dimensions.ai/details/publication/pub.1023636187"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_174.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00542040"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00542040'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00542040'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00542040'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00542040'


 

This table displays all metadata directly associated to this object as RDF triples.

152 TRIPLES      21 PREDICATES      69 URIs      59 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00542040 schema:about N1bf9182c8abd40a38fe7e39af14b5dff
2 N4c027a0ece3c4efdaf7549c0f8ea47c7
3 N59e83dd830ec495dbf91a0a61bcab244
4 N62c5d2fb18134baf9a503af0557acd65
5 N907ebb8abaa648c6ae74a44c30fb0aa3
6 N92d34109b3894b03850d1152913b30ff
7 Nd5356d16cbf74760bc8c73e23f26dc17
8 Ned5f8a8981444b2a9abcffbfd0f76ed3
9 Nee4c7db381d144819510d0304a7bb5be
10 anzsrc-for:11
11 anzsrc-for:1102
12 schema:author Ndcbe56cee2694858bbb410f6d6a6d21d
13 schema:citation sg:pub.10.1007/bf00507111
14 sg:pub.10.1007/bf00563551
15 schema:datePublished 1982-11
16 schema:datePublishedReg 1982-11-01
17 schema:description Experiments were performed in a randomized double blind cross-over study in 6 healthy volunteers to answer the question if alinidine, a new analogue of clonidine with a bradycardic effect directly on the sinus node, would have an effect on an emotionally — induced tachycardia. Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine.
18 schema:genre article
19 schema:isAccessibleForFree false
20 schema:isPartOf N39e4e26be326491886124bf355bec118
21 N98196d3bda74453e8eee15ebb02c6281
22 sg:journal.1054337
23 schema:keywords alinidine
24 analogues
25 blind cross-over study
26 blood flow
27 blood pressure
28 bradycardic effects
29 clonidine
30 concomitant rise
31 cross-over study
32 diastolic blood pressure
33 double-blind cross-over study
34 effect
35 effect of alinidine
36 efficiency
37 experiments
38 flow
39 forearm blood flow
40 healthy volunteers
41 men
42 mental tasks
43 new analogues
44 nodes
45 pressure
46 questions
47 randomized double-blind cross-over study
48 rise
49 sinus node
50 stress
51 study
52 tachycardia
53 task
54 volunteers
55 schema:name The effect of alinidine (St 567) on emotionally induced tachycardia in man
56 schema:pagination 467-471
57 schema:productId N3370f896a1bc41a290ce337406d93918
58 N63b04c99abfd4af0a7d1d23aa7f07fca
59 Nfa1da3343b304e5984c32a16af909ea2
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023636187
61 https://doi.org/10.1007/bf00542040
62 schema:sdDatePublished 2022-11-24T20:45
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N9c5c39fe7c07474f866dcd99057a25d0
65 schema:url https://doi.org/10.1007/bf00542040
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N1bf9182c8abd40a38fe7e39af14b5dff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Blood Pressure
71 rdf:type schema:DefinedTerm
72 N3370f896a1bc41a290ce337406d93918 schema:name dimensions_id
73 schema:value pub.1023636187
74 rdf:type schema:PropertyValue
75 N368d6c775d58480abe155a597e7f0f50 rdf:first sg:person.050701730.05
76 rdf:rest N972f2d898c2849b99999e08b90f92e0d
77 N39e4e26be326491886124bf355bec118 schema:volumeNumber 21
78 rdf:type schema:PublicationVolume
79 N4c027a0ece3c4efdaf7549c0f8ea47c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Tachycardia
81 rdf:type schema:DefinedTerm
82 N59e83dd830ec495dbf91a0a61bcab244 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Male
84 rdf:type schema:DefinedTerm
85 N62c5d2fb18134baf9a503af0557acd65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Clonidine
87 rdf:type schema:DefinedTerm
88 N63b04c99abfd4af0a7d1d23aa7f07fca schema:name doi
89 schema:value 10.1007/bf00542040
90 rdf:type schema:PropertyValue
91 N907ebb8abaa648c6ae74a44c30fb0aa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Humans
93 rdf:type schema:DefinedTerm
94 N92d34109b3894b03850d1152913b30ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Stress, Psychological
96 rdf:type schema:DefinedTerm
97 N972f2d898c2849b99999e08b90f92e0d rdf:first Nc694574818524ad79a6f3b6575ef7d65
98 rdf:rest rdf:nil
99 N98196d3bda74453e8eee15ebb02c6281 schema:issueNumber 6
100 rdf:type schema:PublicationIssue
101 N9c5c39fe7c07474f866dcd99057a25d0 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 Nc694574818524ad79a6f3b6575ef7d65 schema:affiliation grid-institutes:grid.5771.4
104 schema:familyName Olbrich
105 schema:givenName E.
106 rdf:type schema:Person
107 Nd5356d16cbf74760bc8c73e23f26dc17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Heart Rate
109 rdf:type schema:DefinedTerm
110 Ndcbe56cee2694858bbb410f6d6a6d21d rdf:first sg:person.01121360562.16
111 rdf:rest N368d6c775d58480abe155a597e7f0f50
112 Ned5f8a8981444b2a9abcffbfd0f76ed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Adult
114 rdf:type schema:DefinedTerm
115 Nee4c7db381d144819510d0304a7bb5be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Drug Evaluation
117 rdf:type schema:DefinedTerm
118 Nfa1da3343b304e5984c32a16af909ea2 schema:name pubmed_id
119 schema:value 7075652
120 rdf:type schema:PropertyValue
121 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
122 schema:name Medical and Health Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
125 schema:name Cardiorespiratory Medicine and Haematology
126 rdf:type schema:DefinedTerm
127 sg:journal.1054337 schema:issn 0031-6970
128 1432-1041
129 schema:name European Journal of Clinical Pharmacology
130 schema:publisher Springer Nature
131 rdf:type schema:Periodical
132 sg:person.01121360562.16 schema:affiliation grid-institutes:grid.5771.4
133 schema:familyName Auböck
134 schema:givenName J.
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121360562.16
136 rdf:type schema:Person
137 sg:person.050701730.05 schema:affiliation grid-institutes:grid.5771.4
138 schema:familyName Konzett
139 schema:givenName H.
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.050701730.05
141 rdf:type schema:Person
142 sg:pub.10.1007/bf00507111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000492242
143 https://doi.org/10.1007/bf00507111
144 rdf:type schema:CreativeWork
145 sg:pub.10.1007/bf00563551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031317437
146 https://doi.org/10.1007/bf00563551
147 rdf:type schema:CreativeWork
148 grid-institutes:grid.5771.4 schema:alternateName Department of Biostatistics and Documentation, University of Innsbruck, Austria
149 Department of Pharmacology, University of Innsbruck, Austria
150 schema:name Department of Biostatistics and Documentation, University of Innsbruck, Austria
151 Department of Pharmacology, University of Innsbruck, Austria
152 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...