75, 77Br- and 123I-analogues of d-glucose as potential tracers for glucose utilisation in heart and brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-06

AUTHORS

G. Kloster, P. Laufer, W. Wutz, G. Stöcklin

ABSTRACT

A number of D-glucose analogues labelled with either the positron emitter 75Br (T 1/2 = 1.6 h) or the single photon emitter 123I (T 1/2 = 13.3 h) were studied as potential tracers for glucose utilisation in heart and brain. Of these, 3-deoxy-3-bromo-D-glucose, 3-deoxy-3-iodo-D-glucose, methyl 2-deoxy-2-bromo-beta-D-glucoside and methyl 2-deoxy-2-iodo-beta-D-glucoside showed little uptake of radioactivity into brain and an unfavourable ratio of heart-to-blood and heart-to-lung concentrations. In contrast, methyl 3,4,6-tri-O-acetyl-2-deoxy-2-iodo-beta-D-glucoside (MTIG) and methyl 3,4,6-tri-O-acetyl-2-deoxy-2-bromo-beta-D-glucoside (MTBG) showed promising brain uptake (160% MBC for MTBG) with a good brain-to-blood concentration ratio of 0.8. MTBG is not metabolically altered in the brain. Thus, this compound may be a promising tracer for measuring glucose transport if it proves to be a substrate for the hexose carrier at the blood-brain-barrier. More... »

PAGES

237-241

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00522512

DOI

http://dx.doi.org/10.1007/bf00522512

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004528914

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6873102


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