Synthesis of cephalosporin C by a methionine analogue resistant mutant of Cephalosporium acremonium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-06

AUTHORS

Masazumi Matsumura, Toshiomi Yoshida, Hisaharu Taguchi

ABSTRACT

DL-seleno-methionine resistant mutants of Cephalosporium acremonium were isolated which have an enhanced capacity to utilized sulfate for the synthesis of cephalosporin C. Of these mutants, one designated as SMR-I3 produced three-fold more cephalosporin C from sulfate than its parent CW19. Mutant SMR-I3 required less dl-methionine for maximal synthesis of cephalosporin C, but an excess of dl-methionine inhibited the synthesis of the antibiotic. Furthermore, the mutant accumulated excessive methionine in the amino acid pool and possessed superior activity for sulfate uptake. These observations indicate that in the mutant SMR-I3, the biosynthesis of methionine from sulfate is very active and excess methionine becomes available for the synthesis of cephalosporin C. More... »

PAGES

114-118

References to SciGraph publications

Journal

TITLE

Applied Microbiology and Biotechnology

ISSUE

2-3

VOLUME

16

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00500737

DOI

http://dx.doi.org/10.1007/bf00500737

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045696591


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