Improvement of Escherichia coli strains overproducing lysine using recombinant DNA techniques View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1982-12

AUTHORS

Brigitte Dauce-Le Reverend, Michèle Boitel, Alain M. Deschamps, Jean-Michel Lebeault, Konosuke Sano, Koichi Takinami, Jean-Claude Patte

ABSTRACT

Several genes of the lysine biosynthetic pathway were cloned separately on the high copy number plasmid pBR322 (Richaud et al. 1981). These hybrid plasmids were used to transform an Escherichia coli strain TOC R 21 that overproduces lysine due to mutations altering the aspartokinase reaction. The synthesis of lysine was studied in these different strains. It appears that only plasmids containing the dapA gene (encoding dihydrodipicolinate synthetase) lead to an increase in lysine production. This result allows us to identify this reaction as the limiting biosynthetic step in strain TOC R 21 and indicates that such a method of gene amplification can be used to improve strains overproducing metabolites. More... »

PAGES

227-231

Journal

TITLE

Applied Microbiology and Biotechnology

ISSUE

4

VOLUME

15

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00499961

    DOI

    http://dx.doi.org/10.1007/bf00499961

    DIMENSIONS

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