Uncoupling between beta-adrenoceptors and adenylate cyclase in dog ischemic myocardium View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-10

AUTHORS

C. Devos, P. Robberecht, P. Nokin, M. Waelbroeck, M. Clinet, J. C. Camus, P. Beaufort, P. Schoenfeld, J. Christophe

ABSTRACT

We evaluated the effects of ischemic injury on the myocardial adenylate cyclase system, 5 h after ligation of the left anterior descending coronary in 5 anesthetized dogs. Crude cardiac membrane preparations were isolated from control and ischemic areas of ventricular myocardium and tested for: 1. L-(125I)iodocyanopindolol binding, in the absence and presence of ±-isoprenaline and GTP, and 2. adenylate cyclase activity. The density of beta-adrenoceptors increased by 35% in membranes from ischemic areas while the proportion of receptors in a high affinity state for ±-isoprenaline decreased from 43% to 20%. Adenylate cyclase activities in the basal state and under stimulation with NaF, forskolin, Gpp(NH)p, ±-isoprenaline and VIP were all markedly and similarly reduced, being only about 30% of comparable activities in membranes from control areas. The ±-isoprenaline subsensitivity of cardiac adenylate cyclase can, thus, be attributed to a defective enzymatic system and not to a reduction in the number of beta-adrenoceptors implying that the internal components of the system were more sensitive to acute ischemia than the outward oriented hormone receptors. It is tempting to ascribe this uncoupling to a functional depletion in the guanine nucleotide-binding regulatory protein Ns that might reflect a loss of high energy phosphate stores including GTP. More... »

PAGES

71-75

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00498853

DOI

http://dx.doi.org/10.1007/bf00498853

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052202866

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2999617


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