Phosphoglucomutase electrophoretic variants in the mouse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1969-02

AUTHORS

Thomas B. Shows, Frank H. Ruddle, Thomas H. Roderick

ABSTRACT

The phosphoglucomutase (PGM) electrophoretic phenotype of the mouse (Mus musculus) consists of several distinct components which can be grouped into two major zones designated PGM-1 and PGM-2. Evidence presented here indicates that each zone is controlled by a single genetic locus denoted Pgm-1 and Pgm-2, respectively. Two variant forms segregated at the Pgm-1 locus. They were codominantly expressed and inherited as alleles at an autosomal locus. The alleles were termed Pgm-1a (fast) and Pgm-1b (slow). These alleles were separately fixed in a number of inbred strains of mice. Preliminary evidence based on wild mouse phenotypes indicates that variant forms also exist for PGM-2 which are inherited as alleles at an autosomal locus. Genetic linkage relationships have not been determined for these loci. PGM-1 variants and PGM-2 were expressed in mouse fibroblasts in vitro. More... »

PAGES

25-35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00485972

DOI

http://dx.doi.org/10.1007/bf00485972

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012647022


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