Glutamate oxalate transaminase (GOT) genetics in Mus musculus: Linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1970-04

AUTHORS

Robert J. DeLorenzo, Frank H. Ruddle

ABSTRACT

A comparison of electrophoretic patterns of F1 and backcross progeny of two inbred strains of mice has revealed a new autosomal variant of the mitochondrial form of GOT. The loci controlling the production of the soluble and mitochondrial forms of GOT have been designated Got-1 and Got-2, respectively. The two alleles of the Got-2 locus have been designated Got-2a and Got-2b, which represent the slow- and fast-migrating electrophoretic forms. Twenty-seven inbred strains of mice have been classified for Got-2a and Got-2b. It has been demonstrated that the polymorphism of Got-2 is widely distributed in feral mice. Got-2 was shown to be linked to Es-1, and evidence is also presented for linkage between Got-2 and Es-2, Es-5, and oligosyndactyly (Os). The absence of linkage of Got-2 to seven other loci has also been demonstrated. GOT was expressed in vitro in cell lines derived from human and mouse tissues. More... »

PAGES

259-273

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00485777

DOI

http://dx.doi.org/10.1007/bf00485777

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034472911

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4193185


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