Evidence for linkage between glucose 6-phosphate dehydrogenase and hypoxanthine-guanine-phosphoribosyl transferase loci in Chinese hamster cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1971-12

AUTHORS

A. Westerveld, R. P. L. S. Visser, M. A. Freeke

ABSTRACT

G6PD and 6PGD activities were determined in diploid, hyperdiploid, tetraploid, and hybrid cells all originating from the same Chinese hamster cell line (the DON line). A relationship between gene multiplicity and enzyme activity has been observed. The same enzymes were studied in hybrid cells cultivated in selective media. Selection was carried out against and for the HGPRT+ locus. The differences in G6PD and 6PGD activities between the cell lines found under these conditions indicate a positive linkage of the G6PD and HGPRT loci and negative linkage of the 6PGD and HGPRT loci in these Chinese hamster cells. More... »

PAGES

591-599

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00485676

DOI

http://dx.doi.org/10.1007/bf00485676

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020419526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/5116523


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