Inhibition of the yeast-mycelial transition and the phorogenesis of Mucorales by diamino butanone View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-12

AUTHORS

M. Martinez-Pacheco, G. Rodriguez, G. Reyna, C. Calvo-Mendez, J. Ruiz-Herrera

ABSTRACT

Diamino butanone (DAB), a competitive inhibitor of ornithine decarboxylase (ODC) a key enzyme in polyamine biosynthesis, inhibited the yeast to hyphae transition in Mucor rouxii, induced by transfer from anaerobiosis to aerobiosis, but not the opposite phenomenon. Addition of DAB to anaerobic yeast cells brought about a decrease in ODC and polyamine levels. In these conditions, the aerobic shift produced only a weak increase in ODC activity and no change in polyamine levels. DAB also blocked phorogenesis in M. rouxii and in Phycomyces blakesleeanus. At the effective concentrations DAB did not affect cell growth of either fungus. It is suggested that low, constant levels of ODC and polyamines are necessary for cell growth, and that high transient levels are required during the differentiative steps. DAB, at the concentrations used, affects this last process, but does not interfere with the maintenance level of polyamines. More... »

PAGES

10-14

References to SciGraph publications

  • 1985. Mucor racemosus in FUNGAL DIMORPHISM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00444661

    DOI

    http://dx.doi.org/10.1007/bf00444661

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050653192

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/2916900


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