Immunosuppressive effect of paracoccidioidomycosis sera on the proliferative response of normal mononuclear cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-08

AUTHORS

Dumith Chequer-Bou-Habib, Maria de Fátima Ferreira-da-Cruz, Bernardo Galvão-Castro

ABSTRACT

In this paper we relate that sera from paracoccidioidomycosis patients inhibited the mitogen-induced proliferative responses of normal mononuclear cells. Treatment of these sera with 2.5% polyethyleneglycol (PEG), a method classically used to precipitate immune complexes, significantly reduced their inhibitory activity. Immunoblot analysis of the PEG precipitates identified a 34-kDa polypeptide, recognized by rabbit anti-P. brasiliensis IgG. Patient mononuclear cells showed partial restoration of their proliferative capacity after 24 h culture in medium alone, which suggests release of membrane-bound molecules in the culture medium. These findings indicate that circulating P. brasiliensis antigens, complexed or not with antibodies, may play a negative immunoregulatory effect in the mitogen-induced proliferative responses of paracoccidioidomycosis patients. More... »

PAGES

65-71

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00443935

DOI

http://dx.doi.org/10.1007/bf00443935

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009897611

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1435949


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