Antibiotic tetaine — a selective inhibitor of chitin and mannoprotein biosynthesis in Candida albicans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-08

AUTHORS

Slawomir Milewski, Henryk Chmara, Edward Borowski

ABSTRACT

The antibiotic tetaine inhibits in Candida albicans the biosynthesis of two important cell wall constituents, chitin and mannoprotein. This effect is a consequence of inactivation of the enzyme glucosamine-6-phosphate synthetase. Due to the lack of glucosamine-6-phosphate the effective secretion of mannoprotein enzymes, acid phosphatase and invertase, by Candida albicans spheroplasts is inhibited. In the presence of tetaine, probably a modified mannoprotein, lacking a branched polymannan, is synthesized. The antibiotic action decreases the viability of Candida albicans cells, especially that of mycelial forms of this fungus. More... »

PAGES

234-240

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00443651

DOI

http://dx.doi.org/10.1007/bf00443651

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017492697

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3532988


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