A comparison of the effects of diazepam versus several typical and atypical anti-depressant drugs in an animal model of anxiety View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1989-02

AUTHORS

Shari R. Bodnoff, Barbara Suranyi-Cadotte, Remi Quirion, Michael J. Meaney

ABSTRACT

We examined the anxiolytic effects of a variety of anti-depressant drugs, administered either acutely or chronically, in an animal model of anxiety involving novelty-suppressed feeding in food-deprived rats. Following a single injection of desipramine (10 mg/kg) amitriptyline (10 mg/kg), mianserin (10 mg/kg), fluoxetine (10 mg/kg), buspirone (4 mg/kg), gepirone (4 mg/kg) or nomifensine (10 mg/kg), there was no decrease in the latency to begin eating in the novel environment such as occurred with diazepam (2 mg/kg). In fact, an increased latency was observed for desipramine, amitriptyline, fluoxetine, and nomifensine. In contrast, chronic (21 days) treatment with each of the above-mentioned drugs, except nomifensine, significantly reduced the latency to begin eating relative to vehicle controls. These findings suggest that a variety of tricyclic and novel anti-depressant drugs acquire anxiolytic properties following chronic administration. More... »

PAGES

277-279

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00442264

DOI

http://dx.doi.org/10.1007/bf00442264

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036462729

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2567028


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