Prediction of type 1 diabetes mellitus—a report on three cases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1985-01

AUTHORS

G. J. Bruining, J. L. Molenaar, B. M. de Jongh, R. S. R. Aarsen, H. K. A. Visser

ABSTRACT

In three children (patients 1, 2 and 3) insulin-dependency was predicted 28, 32 and 4 months, respectively before the disease became clinically manifest, by the finding of islet cell antibodies at that time. These retrospective findings support the evidence for a long pre-diabetic phase in childhood diabetes, marked by the presence of islet cell antibodies, as well as the linkage of HLA-antigens to the susceptibility to this disease. The possibility of detecting pre-diabetic states in children before the endogenous insulin secretion decreases to the point of producing clinical symptoms support efforts by basic scientists to develop techniques for immunological intervention early in the course of the disease. More... »

PAGES

175-178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00442131

DOI

http://dx.doi.org/10.1007/bf00442131

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026528751

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3987708


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