Clinical pharmacology of tamoxifen and N-desmethyltamoxifen in patients with advanced breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-12

AUTHORS

Peter Wilkinson, Gerald Ribeiro, Hugh Adam, John Patterson

ABSTRACT

Serum concentrations of tamoxifen and its metabolite, N-desmethyltamoxifen (DMT) were determined in six post-menopausal patients with advanced breast cancer. Following a single 10-mg dose PO parent drug was detected in the serum, with a peak concentration of 17.5 ng/ml. Concentrations of the N-desmethyl metabolite were below the limit of detection (less than 2.5 ng/ml). After 21 days' oral therapy with 10 mg b.i.d. the serum concentration of tamoxifen had increased ten fold, while DMT was now present in comparable amounts. Two patients were further studied for a longer time period. There was little change in the serum concentration of tamoxifen, while the DMT increased two fold above its value at 21 days. More... »

PAGES

109-111

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00435413

DOI

http://dx.doi.org/10.1007/bf00435413

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051415322

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7471314


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