Light and electron microscopic studies on rat arterial lesions induced by experimental arterial contraction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-12

AUTHORS

Kiyohisa Kobori, Keiji Suzuki, Yoji Yoshida, Genju Ooneda

ABSTRACT

Experimental contraction was produced in the rat mesenteric arteries and the arterial segments were studied morphologically. When the rat mesenteric artery was exposed in physiological saline solution at 37° C and 2–3 mg of methoxamine hydrochloride (10 mg/ml) was dripped onto it, intense contraction was observed for about 30 min but elevation in blood pressure was slight. During the contraction, numerous vacuoles were seen in the medial smooth muscle cells of the arterial segments, and these vacuoles were shown electron microscopically to have double unit membranes, indicating that they were formed by herniation of a part of the adjacent smooth muscle cell body. In the arteries 1–6 h after the end of the contraction, cellular, nuclear and vacuolar membranes and myofilaments of the medial muscle cells were partially lost. 12–24 h after the contraction the arteries exhibited necrosis and desquamation of endothelial cells and platelet adhesion. In the media, smooth muscle cells were completely deprived of cell membranes, myofilaments, nuclei, intracytoplasmic organelles other than mitochondria, and vacuolar membranes. The cytoplasm was filled with fine granular and granulo-vesicular material, and fibrin insudation was observed in these severely damaged cells. Arterial contraction may be an important factor in the induction of arterial lesions. More... »

PAGES

29-39

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00433538

DOI

http://dx.doi.org/10.1007/bf00433538

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021459916

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/162098


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Constriction, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeleton", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membranes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenteric Arteries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methoxamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Electron", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Necrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vacuoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobori", 
        "givenName": "Kiyohisa", 
        "id": "sg:person.055425411.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055425411.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Keiji", 
        "id": "sg:person.010337722674.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010337722674.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Yoji", 
        "id": "sg:person.0111607231.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111607231.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.256642.1", 
          "name": [
            "Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ooneda", 
        "givenName": "Genju", 
        "id": "sg:person.053317326.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053317326.51"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1979-12", 
    "datePublishedReg": "1979-12-01", 
    "description": "Experimental contraction was produced in the rat mesenteric arteries and the arterial segments were studied morphologically. When the rat mesenteric artery was exposed in physiological saline solution at 37\u00b0 C and 2\u20133 mg of methoxamine hydrochloride (10 mg/ml) was dripped onto it, intense contraction was observed for about 30 min but elevation in blood pressure was slight. During the contraction, numerous vacuoles were seen in the medial smooth muscle cells of the arterial segments, and these vacuoles were shown electron microscopically to have double unit membranes, indicating that they were formed by herniation of a part of the adjacent smooth muscle cell body. In the arteries 1\u20136 h after the end of the contraction, cellular, nuclear and vacuolar membranes and myofilaments of the medial muscle cells were partially lost. 12\u201324 h after the contraction the arteries exhibited necrosis and desquamation of endothelial cells and platelet adhesion. In the media, smooth muscle cells were completely deprived of cell membranes, myofilaments, nuclei, intracytoplasmic organelles other than mitochondria, and vacuolar membranes. The cytoplasm was filled with fine granular and granulo-vesicular material, and fibrin insudation was observed in these severely damaged cells. Arterial contraction may be an important factor in the induction of arterial lesions.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00433538", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009231", 
        "issn": [
          "0174-7398"
        ], 
        "name": "Virchows Archiv A Pathological Anatomy and Histopathology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "385"
      }
    ], 
    "keywords": [
      "rat mesenteric arteries", 
      "smooth muscle cells", 
      "arterial contraction", 
      "mesenteric artery", 
      "arterial lesions", 
      "muscle cells", 
      "arterial segments", 
      "medial smooth muscle cells", 
      "medial muscle cells", 
      "fibrin insudation", 
      "blood pressure", 
      "artery 1", 
      "methoxamine hydrochloride", 
      "physiological saline solution", 
      "intense contraction", 
      "cell bodies", 
      "artery", 
      "electron microscopic study", 
      "endothelial cells", 
      "contraction", 
      "intracytoplasmic organelles", 
      "lesions", 
      "saline solution", 
      "numerous vacuoles", 
      "myofilaments", 
      "microscopic study", 
      "cells", 
      "platelet adhesion", 
      "experimental contractions", 
      "herniation", 
      "insudation", 
      "necrosis", 
      "desquamation", 
      "cell membrane", 
      "elevation", 
      "induction", 
      "important factor", 
      "vacuoles", 
      "membrane", 
      "min", 
      "segments", 
      "hydrochloride", 
      "factors", 
      "study", 
      "cytoplasm", 
      "mitochondria", 
      "nucleus", 
      "pressure", 
      "body", 
      "double unit membrane", 
      "adhesion", 
      "organelles", 
      "unit membrane", 
      "end", 
      "vacuolar membrane", 
      "part", 
      "medium", 
      "materials", 
      "muscle cell bodies", 
      "light", 
      "solution", 
      "electrons", 
      "adjacent smooth muscle cell body", 
      "smooth muscle cell body", 
      "granulo-vesicular material", 
      "rat arterial lesions", 
      "experimental arterial contraction"
    ], 
    "name": "Light and electron microscopic studies on rat arterial lesions induced by experimental arterial contraction", 
    "pagination": "29-39", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021459916"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00433538"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "162098"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00433538", 
      "https://app.dimensions.ai/details/publication/pub.1021459916"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_119.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00433538"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00433538'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00433538'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00433538'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00433538'


 

This table displays all metadata directly associated to this object as RDF triples.

205 TRIPLES      21 PREDICATES      108 URIs      100 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00433538 schema:about N09a579d212864407997f9bbdc514cc65
2 N1cfd589c390848d287dc3a143c07cab6
3 N26e15f91e8d94e87a6a129cb0021d410
4 N2bdb03a3a4fb4e6784e8c7f667b7d3c6
5 N3aa2ffff9cd2478a90e98126c9fffe98
6 N410c7bc51d404d8eadc4e7b9ab499201
7 N4fdac4acb67c4fb6a2d9fd6ef948562d
8 Na039a0826c184a29990a61d0e06fc78a
9 Nb837747cb7f3416e98e32a494de7e6c1
10 Nd061acf3bbc34f0dbe59ebe8845db7ce
11 Ne1eaecb482884e01b222c2f1138dc93a
12 Ne433ca6b66e24d43add2693b2913e0a1
13 Nedf89de399734641a1363019717d2c41
14 Nf1e394b486ba4f7c90636f8a2c752fbe
15 anzsrc-for:11
16 anzsrc-for:1116
17 schema:author N228a489b443d433abf6940a4a99311e0
18 schema:datePublished 1979-12
19 schema:datePublishedReg 1979-12-01
20 schema:description Experimental contraction was produced in the rat mesenteric arteries and the arterial segments were studied morphologically. When the rat mesenteric artery was exposed in physiological saline solution at 37° C and 2–3 mg of methoxamine hydrochloride (10 mg/ml) was dripped onto it, intense contraction was observed for about 30 min but elevation in blood pressure was slight. During the contraction, numerous vacuoles were seen in the medial smooth muscle cells of the arterial segments, and these vacuoles were shown electron microscopically to have double unit membranes, indicating that they were formed by herniation of a part of the adjacent smooth muscle cell body. In the arteries 1–6 h after the end of the contraction, cellular, nuclear and vacuolar membranes and myofilaments of the medial muscle cells were partially lost. 12–24 h after the contraction the arteries exhibited necrosis and desquamation of endothelial cells and platelet adhesion. In the media, smooth muscle cells were completely deprived of cell membranes, myofilaments, nuclei, intracytoplasmic organelles other than mitochondria, and vacuolar membranes. The cytoplasm was filled with fine granular and granulo-vesicular material, and fibrin insudation was observed in these severely damaged cells. Arterial contraction may be an important factor in the induction of arterial lesions.
21 schema:genre article
22 schema:inLanguage en
23 schema:isAccessibleForFree false
24 schema:isPartOf N1f1b86e120834a8d81c9ed2e25a6f4e8
25 Ne24b3c6f66064a21b64c1f678232df7f
26 sg:journal.1009231
27 schema:keywords adhesion
28 adjacent smooth muscle cell body
29 arterial contraction
30 arterial lesions
31 arterial segments
32 artery
33 artery 1
34 blood pressure
35 body
36 cell bodies
37 cell membrane
38 cells
39 contraction
40 cytoplasm
41 desquamation
42 double unit membrane
43 electron microscopic study
44 electrons
45 elevation
46 end
47 endothelial cells
48 experimental arterial contraction
49 experimental contractions
50 factors
51 fibrin insudation
52 granulo-vesicular material
53 herniation
54 hydrochloride
55 important factor
56 induction
57 insudation
58 intense contraction
59 intracytoplasmic organelles
60 lesions
61 light
62 materials
63 medial muscle cells
64 medial smooth muscle cells
65 medium
66 membrane
67 mesenteric artery
68 methoxamine hydrochloride
69 microscopic study
70 min
71 mitochondria
72 muscle cell bodies
73 muscle cells
74 myofilaments
75 necrosis
76 nucleus
77 numerous vacuoles
78 organelles
79 part
80 physiological saline solution
81 platelet adhesion
82 pressure
83 rat arterial lesions
84 rat mesenteric arteries
85 saline solution
86 segments
87 smooth muscle cell body
88 smooth muscle cells
89 solution
90 study
91 unit membrane
92 vacuolar membrane
93 vacuoles
94 schema:name Light and electron microscopic studies on rat arterial lesions induced by experimental arterial contraction
95 schema:pagination 29-39
96 schema:productId Nbc2ec2a44a1845cd81c03664b6839fb2
97 Nd1d1f42ea5f04b958fc2f1a9e06fed0a
98 Ndac2aa504709426fa4a93fce4be5a27d
99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021459916
100 https://doi.org/10.1007/bf00433538
101 schema:sdDatePublished 2022-01-01T18:00
102 schema:sdLicense https://scigraph.springernature.com/explorer/license/
103 schema:sdPublisher Na064b9e087db4b208e523d01f498124a
104 schema:url https://doi.org/10.1007/bf00433538
105 sgo:license sg:explorer/license/
106 sgo:sdDataset articles
107 rdf:type schema:ScholarlyArticle
108 N09a579d212864407997f9bbdc514cc65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Constriction, Pathologic
110 rdf:type schema:DefinedTerm
111 N1cfd589c390848d287dc3a143c07cab6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Membranes
113 rdf:type schema:DefinedTerm
114 N1f1b86e120834a8d81c9ed2e25a6f4e8 schema:issueNumber 1
115 rdf:type schema:PublicationIssue
116 N228a489b443d433abf6940a4a99311e0 rdf:first sg:person.055425411.25
117 rdf:rest N4705043c829447aeb67e1107171a6a1c
118 N26e15f91e8d94e87a6a129cb0021d410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Necrosis
120 rdf:type schema:DefinedTerm
121 N2bdb03a3a4fb4e6784e8c7f667b7d3c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Endothelium
123 rdf:type schema:DefinedTerm
124 N3aa2ffff9cd2478a90e98126c9fffe98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Mesenteric Arteries
126 rdf:type schema:DefinedTerm
127 N3b33d872d9cd40faa4fba8e4c266f34e rdf:first sg:person.0111607231.02
128 rdf:rest N6668b9d689e9490cbd0d5a2641390cb8
129 N410c7bc51d404d8eadc4e7b9ab499201 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Microscopy, Electron
131 rdf:type schema:DefinedTerm
132 N4705043c829447aeb67e1107171a6a1c rdf:first sg:person.010337722674.92
133 rdf:rest N3b33d872d9cd40faa4fba8e4c266f34e
134 N4fdac4acb67c4fb6a2d9fd6ef948562d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Animals
136 rdf:type schema:DefinedTerm
137 N6668b9d689e9490cbd0d5a2641390cb8 rdf:first sg:person.053317326.51
138 rdf:rest rdf:nil
139 Na039a0826c184a29990a61d0e06fc78a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cytoskeleton
141 rdf:type schema:DefinedTerm
142 Na064b9e087db4b208e523d01f498124a schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Nb837747cb7f3416e98e32a494de7e6c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Time Factors
146 rdf:type schema:DefinedTerm
147 Nbc2ec2a44a1845cd81c03664b6839fb2 schema:name dimensions_id
148 schema:value pub.1021459916
149 rdf:type schema:PropertyValue
150 Nd061acf3bbc34f0dbe59ebe8845db7ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Vacuoles
152 rdf:type schema:DefinedTerm
153 Nd1d1f42ea5f04b958fc2f1a9e06fed0a schema:name pubmed_id
154 schema:value 162098
155 rdf:type schema:PropertyValue
156 Ndac2aa504709426fa4a93fce4be5a27d schema:name doi
157 schema:value 10.1007/bf00433538
158 rdf:type schema:PropertyValue
159 Ne1eaecb482884e01b222c2f1138dc93a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Rats
161 rdf:type schema:DefinedTerm
162 Ne24b3c6f66064a21b64c1f678232df7f schema:volumeNumber 385
163 rdf:type schema:PublicationVolume
164 Ne433ca6b66e24d43add2693b2913e0a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Male
166 rdf:type schema:DefinedTerm
167 Nedf89de399734641a1363019717d2c41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Muscle, Smooth
169 rdf:type schema:DefinedTerm
170 Nf1e394b486ba4f7c90636f8a2c752fbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Methoxamine
172 rdf:type schema:DefinedTerm
173 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
174 schema:name Medical and Health Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical Physiology
178 rdf:type schema:DefinedTerm
179 sg:journal.1009231 schema:issn 0174-7398
180 schema:name Virchows Archiv A Pathological Anatomy and Histopathology
181 schema:publisher Springer Nature
182 rdf:type schema:Periodical
183 sg:person.010337722674.92 schema:affiliation grid-institutes:grid.256642.1
184 schema:familyName Suzuki
185 schema:givenName Keiji
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010337722674.92
187 rdf:type schema:Person
188 sg:person.0111607231.02 schema:affiliation grid-institutes:grid.256642.1
189 schema:familyName Yoshida
190 schema:givenName Yoji
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111607231.02
192 rdf:type schema:Person
193 sg:person.053317326.51 schema:affiliation grid-institutes:grid.256642.1
194 schema:familyName Ooneda
195 schema:givenName Genju
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053317326.51
197 rdf:type schema:Person
198 sg:person.055425411.25 schema:affiliation grid-institutes:grid.256642.1
199 schema:familyName Kobori
200 schema:givenName Kiyohisa
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055425411.25
202 rdf:type schema:Person
203 grid-institutes:grid.256642.1 schema:alternateName Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan
204 schema:name Second Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan
205 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...