Effects of pentazocine and other opiates on shock detection in the rat: Involvement of opiate and dopamine receptors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-02

AUTHORS

Linda L. Hernández, James B. Appel

ABSTRACT

The hypothesis that the antinociceptive effects of pentazocine, a mixed agonist-antagonist opiate of the benzomorphan class, are mediated by a dual opiate-dopaminergic mechanism was tested using a two-choice procedure in which rats were required to discriminate the presence or absence of shock. The results showed that pentazocine decreased shock sensitivity and speed of responding, effects that were qualitatively similar to those of morphine. However, while the antinociceptive effect of both pentazocine and morphine could be antagonized by opiate receptor blockade, that of pentazocine, but not of morphine, could also be antagonized by dopamine receptor blockade. Observations with levorphanol and phenazocine suggested further that dopamine, as well as opiate receptor agonism may be characteristic of the benzomorphans. More... »

PAGES

155-163

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00431971

DOI

http://dx.doi.org/10.1007/bf00431971

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022238402

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6245423


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