Lipogenesis in situ in the genetically obese Zucker fatty rat (fa/fa): Role of hyperphagia and hyperinsulinaemia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1978-03

AUTHORS

V. Godbole, D. A. York

ABSTRACT

In situ fatty acid synthesis has been measured with 3H2O in anaesthetised lean and obese Zucker (fa/fa) rats. The accumulation of fatty acids was increased in both the liver and adipose tissue of young fa/fa rats as a result of both an increased rate of lipogenesis and an increase in tissue mass. Whereas total hepatic lipogenesis increased with age, total adipose tissue lipogenesis decreased in older fa/fa rats. Experiments with hepatectomized rats showed that the liver was the major site of the excess fatty acid synthesis in fa/fa rats. The enhanced rate of lipogenesis in fa/fa rats was abolished by either pairfeeding or streptozotocin treatment. The results suggest that the increased fatty acid synthesis in fa/fa rats is secondary to the hyperphagia, hpyerinsulinaemia, and increased mass of hepatic and adipose tissues. More... »

PAGES

191-197

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00429780

DOI

http://dx.doi.org/10.1007/bf00429780

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028158860

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/566233


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