Electron microscopic observations of the kidney in the generalized Shwartzman reaction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1977-09

AUTHORS

Teruo Watanabe, Kenzo Tanaka

ABSTRACT

Sequential changes in the kidney during the generalized Shwartzman reaction were studied electron microscopically. The first anatomical change was infiltration of neutrophils into the glomerular capillaries. Endothelial damage was not noticeable until the capillaries were filled with fibrin deposits. Fibrin appeared in the mesangium at almost the same time as in the capillary lumina, traversing through the endothelial fenestrae. Endothelial damage was more common in the mesangial portion than in the peripheral portion of the capillaries. Severe mesangiolysis developed after loss of endothelial cells had been followed by massive penetration of intracapillary contents. Later, signs of repair were evident in some parts of the damaged endothelium. The development of cortical necrosis coincided with the appearance of mesangiolysis and arteriolar thrombotic lesions. More... »

PAGES

183-196

References to SciGraph publications

  • 1976-12. Accelerated serum sickness in the rabbit in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00427113

    DOI

    http://dx.doi.org/10.1007/bf00427113

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014648761

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/142345


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