A comparison of some pharmacological actions of morphine and Δ9-tetrahydrocannabinol in the mouse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1978-01

AUTHORS

Alan S. Bloom, William L. Dewey

ABSTRACT

The effects of morphine and Δ9-tetrahydrocannabinol (THC) on the tail-flick reflex, body temperature, and catecholamine synthesis were examined in the mouse in order to compare their effects in a single species and strain under uniform conditions. Naloxone antagonism of THC and cross-tolerance between morphine and THC were also studied. Both morphine and THC produced antinociception, hypothermia, and increased catecholamine synthesis at 30 min after s.c. injection. Morphine produced greater increases in dopamine synthesis and was a more potent antinociceptive agent, while THC produced greater increases in norepinephrine synthesis and was a more potent hypothermic agent. Naloxone pretreatment (1 mg/kg) partially antagonized the hypothermia and increase in catecholamine synthesis produced by THC. There was also crosstolerance between morphine and THC, but it was asymmetric in that THC-tolerant animals were crosstolerant to only the hypothermic action of morphine and morphine-tolerant animals cross-tolerant to only the antinociceptive action of THC. More... »

PAGES

243-248

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00426745

DOI

http://dx.doi.org/10.1007/bf00426745

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048698935

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/97703


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