Prediction of abuse liability of drugs using IV self-administration by rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-12

AUTHORS

R. James Collins, James R. Weeks, Murray M. Cooper, Philip I. Good, Roland R. Russell

ABSTRACT

A total 31 psychoactive drugs were offered to groups of naive rats for IV self-administration and an injection rate greater than that for rats offered only saline indicated reinforcement. Two protocols were used: in the first, rats were offered drug at a selected dose for 5 days, then the dose was reduced by 1 log unit (to 0.1 the original dose) for an additional 4 days; in the second, rats were offered saline for 3 days as a "prescreen' to eliminate rats with high or low operant-injection rates. Drug was offered to acceptable rats for 5 days, then the dose was reduced 0.5 log unit (to 0.32 the original dose) for 5 more days. A scoring system, based upon the injection rates during the last 3 days of each period, describes the reinforcing action. Scores were dose-related. Tests on both protocols gave similar results. Data from monkey studies have been reported for 27 of the drugs tested. Of these drugs, 18 were reinforcers and six were nonreinforcers in both species, nalorphine and ethylketazocine were reinforcers only in rats, and ethanol was a reinforcer only in monkeys. More... »

PAGES

6-13

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00426372

DOI

http://dx.doi.org/10.1007/bf00426372

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027702221

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6141585


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Nervous System Depressants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Nervous System Stimulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplorhini", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Narcotic Antagonists", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Narcotics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reinforcement (Psychology)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Self Administration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substance-Related Disorders", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Departments of CNS Research, Cardiovascular Diseases Research, and Department of Biostatistics, The Upjohn Company, 49001, Kalamazoo, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collins", 
        "givenName": "R. James", 
        "id": "sg:person.0666013665.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666013665.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Departments of CNS Research, Cardiovascular Diseases Research, and Department of Biostatistics, The Upjohn Company, 49001, Kalamazoo, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weeks", 
        "givenName": "James R.", 
        "id": "sg:person.0734127065.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734127065.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Departments of CNS Research, Cardiovascular Diseases Research, and Department of Biostatistics, The Upjohn Company, 49001, Kalamazoo, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cooper", 
        "givenName": "Murray M.", 
        "id": "sg:person.01002242265.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002242265.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Departments of CNS Research, Cardiovascular Diseases Research, and Department of Biostatistics, The Upjohn Company, 49001, Kalamazoo, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Good", 
        "givenName": "Philip I.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Departments of CNS Research, Cardiovascular Diseases Research, and Department of Biostatistics, The Upjohn Company, 49001, Kalamazoo, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russell", 
        "givenName": "Roland R.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0091-3057(81)90319-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001504902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(81)90319-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001504902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0031-6989(74)80039-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012940383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(82)90033-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014458365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(82)90033-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014458365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(77)90254-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021357170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0091-3057(77)90254-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021357170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00405254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028425305", 
          "https://doi.org/10.1007/bf00405254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00405254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028425305", 
          "https://doi.org/10.1007/bf00405254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pa.09.040169.002411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029187794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-512302-0.50010-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032055514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-6980(79)90002-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033039198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-004702-4.50010-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033582076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-6980(76)80003-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038026363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3908(79)90160-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040757517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3908(79)90160-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040757517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cpt1979255part1611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051924375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00433045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053322650", 
          "https://doi.org/10.1007/bf00433045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00433045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053322650", 
          "https://doi.org/10.1007/bf00433045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/biomet/52.3-4.591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059417484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.138.3537.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062478263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079901493", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081682628", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1983-12", 
    "datePublishedReg": "1983-12-01", 
    "description": "A total 31 psychoactive drugs were offered to groups of naive rats for IV self-administration and an injection rate greater than that for rats offered only saline indicated reinforcement. Two protocols were used: in the first, rats were offered drug at a selected dose for 5 days, then the dose was reduced by 1 log unit (to 0.1 the original dose) for an additional 4 days; in the second, rats were offered saline for 3 days as a \"prescreen' to eliminate rats with high or low operant-injection rates. Drug was offered to acceptable rats for 5 days, then the dose was reduced 0.5 log unit (to 0.32 the original dose) for 5 more days. A scoring system, based upon the injection rates during the last 3 days of each period, describes the reinforcing action. Scores were dose-related. Tests on both protocols gave similar results. Data from monkey studies have been reported for 27 of the drugs tested. Of these drugs, 18 were reinforcers and six were nonreinforcers in both species, nalorphine and ethylketazocine were reinforcers only in rats, and ethanol was a reinforcer only in monkeys.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00426372", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085440", 
        "issn": [
          "0033-3158", 
          "1432-2072"
        ], 
        "name": "Psychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "82"
      }
    ], 
    "name": "Prediction of abuse liability of drugs using IV self-administration by rats", 
    "pagination": "6-13", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00426372"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "83f7c5d80767708e6ed17db5c91f802f2de62852616dbd835c3061c55f3b39a3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027702221"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7608025"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "6141585"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00426372", 
      "https://app.dimensions.ai/details/publication/pub.1027702221"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91438_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00426372"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00426372'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00426372'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00426372'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00426372'


 

This table displays all metadata directly associated to this object as RDF triples.

202 TRIPLES      21 PREDICATES      60 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00426372 schema:about N09f2c0ea4cbc43779c1d245618fc6366
2 N1368a377509a45c6a5601d081f4f9729
3 N1a63f9f3c28f4bdb9771c19494c8b454
4 N1baf499ad3714caeb1d9413c21ddb0a1
5 N1c11ed3d488f4f929cc63235e21f270a
6 N2abc2674dec54bc3a6fc58d57f96bb40
7 N8daa8f6bf8d64ede9db36d712bb10dc4
8 N980f5905d1a6486d9b655db148b0364e
9 Nbd00897e85fe40d9b1db7063c37cd306
10 Nbf46c58e3a3348ecbe47bbdb52730c3b
11 Nc61eaec32d184c2795239c752fa4b407
12 Nd2a972283f504dcabfb718229146a56d
13 Nd6884f02436945d5b3b2effed592f20d
14 Nf478af17bc9c47adac98f402a958960f
15 anzsrc-for:11
16 anzsrc-for:1115
17 schema:author Nf9b13d8958784cc18e50cb07e980f384
18 schema:citation sg:pub.10.1007/bf00405254
19 sg:pub.10.1007/bf00433045
20 https://app.dimensions.ai/details/publication/pub.1079901493
21 https://app.dimensions.ai/details/publication/pub.1081682628
22 https://doi.org/10.1002/cpt1979255part1611
23 https://doi.org/10.1016/0028-3908(79)90160-6
24 https://doi.org/10.1016/0090-6980(79)90002-9
25 https://doi.org/10.1016/0091-3057(77)90254-4
26 https://doi.org/10.1016/0091-3057(81)90319-1
27 https://doi.org/10.1016/0091-3057(82)90033-8
28 https://doi.org/10.1016/b978-0-12-004702-4.50010-2
29 https://doi.org/10.1016/b978-0-12-512302-0.50010-9
30 https://doi.org/10.1016/s0031-6989(74)80039-1
31 https://doi.org/10.1016/s0090-6980(76)80003-2
32 https://doi.org/10.1093/biomet/52.3-4.591
33 https://doi.org/10.1126/science.138.3537.143
34 https://doi.org/10.1146/annurev.pa.09.040169.002411
35 schema:datePublished 1983-12
36 schema:datePublishedReg 1983-12-01
37 schema:description A total 31 psychoactive drugs were offered to groups of naive rats for IV self-administration and an injection rate greater than that for rats offered only saline indicated reinforcement. Two protocols were used: in the first, rats were offered drug at a selected dose for 5 days, then the dose was reduced by 1 log unit (to 0.1 the original dose) for an additional 4 days; in the second, rats were offered saline for 3 days as a "prescreen' to eliminate rats with high or low operant-injection rates. Drug was offered to acceptable rats for 5 days, then the dose was reduced 0.5 log unit (to 0.32 the original dose) for 5 more days. A scoring system, based upon the injection rates during the last 3 days of each period, describes the reinforcing action. Scores were dose-related. Tests on both protocols gave similar results. Data from monkey studies have been reported for 27 of the drugs tested. Of these drugs, 18 were reinforcers and six were nonreinforcers in both species, nalorphine and ethylketazocine were reinforcers only in rats, and ethanol was a reinforcer only in monkeys.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree false
41 schema:isPartOf N2098fd859a6147ce9840c4784b9cd45a
42 N76bca8042dab4220a0d44002dff6046e
43 sg:journal.1085440
44 schema:name Prediction of abuse liability of drugs using IV self-administration by rats
45 schema:pagination 6-13
46 schema:productId N0c4498e0020040928b1c4655509ecc4b
47 N4e5d30386eb241a5bcaadc731f56146d
48 N706ef79410164ef391978899e2454919
49 Nd07b82f65aa44fa5a5544b0d39dd9f95
50 Nec353d8933754e158736533cd54e95fa
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027702221
52 https://doi.org/10.1007/bf00426372
53 schema:sdDatePublished 2019-04-15T09:00
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher Nf5c3678d2c0340a4b0e2be8dae47feec
56 schema:url http://link.springer.com/10.1007/BF00426372
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N09f2c0ea4cbc43779c1d245618fc6366 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Reinforcement (Psychology)
62 rdf:type schema:DefinedTerm
63 N0c4498e0020040928b1c4655509ecc4b schema:name nlm_unique_id
64 schema:value 7608025
65 rdf:type schema:PropertyValue
66 N1368a377509a45c6a5601d081f4f9729 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Narcotics
68 rdf:type schema:DefinedTerm
69 N1a63f9f3c28f4bdb9771c19494c8b454 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Humans
71 rdf:type schema:DefinedTerm
72 N1baf499ad3714caeb1d9413c21ddb0a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Female
74 rdf:type schema:DefinedTerm
75 N1c11ed3d488f4f929cc63235e21f270a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Narcotic Antagonists
77 rdf:type schema:DefinedTerm
78 N2098fd859a6147ce9840c4784b9cd45a schema:issueNumber 1-2
79 rdf:type schema:PublicationIssue
80 N2abc2674dec54bc3a6fc58d57f96bb40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Rats
82 rdf:type schema:DefinedTerm
83 N2d4c78cc40914df3807e8a2961d21453 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
84 schema:familyName Good
85 schema:givenName Philip I.
86 rdf:type schema:Person
87 N2e3ba20df04a43d0bd0487634bb0e712 rdf:first Nb5ab8fd3ec754c4784d8de79b813ad06
88 rdf:rest rdf:nil
89 N4e5d30386eb241a5bcaadc731f56146d schema:name dimensions_id
90 schema:value pub.1027702221
91 rdf:type schema:PropertyValue
92 N64d47c6edf7049d6befedb8ebfefc112 rdf:first N2d4c78cc40914df3807e8a2961d21453
93 rdf:rest N2e3ba20df04a43d0bd0487634bb0e712
94 N706ef79410164ef391978899e2454919 schema:name pubmed_id
95 schema:value 6141585
96 rdf:type schema:PropertyValue
97 N76bca8042dab4220a0d44002dff6046e schema:volumeNumber 82
98 rdf:type schema:PublicationVolume
99 N83b48d740fb74dc5969229a345a0cd29 rdf:first sg:person.0734127065.23
100 rdf:rest N8718915a5b7d4279899168aefd30ad73
101 N8718915a5b7d4279899168aefd30ad73 rdf:first sg:person.01002242265.30
102 rdf:rest N64d47c6edf7049d6befedb8ebfefc112
103 N8daa8f6bf8d64ede9db36d712bb10dc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Central Nervous System Stimulants
105 rdf:type schema:DefinedTerm
106 N980f5905d1a6486d9b655db148b0364e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Animals
108 rdf:type schema:DefinedTerm
109 Nb5ab8fd3ec754c4784d8de79b813ad06 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
110 schema:familyName Russell
111 schema:givenName Roland R.
112 rdf:type schema:Person
113 Nbd00897e85fe40d9b1db7063c37cd306 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Haplorhini
115 rdf:type schema:DefinedTerm
116 Nbf46c58e3a3348ecbe47bbdb52730c3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Self Administration
118 rdf:type schema:DefinedTerm
119 Nc61eaec32d184c2795239c752fa4b407 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Rats, Inbred Strains
121 rdf:type schema:DefinedTerm
122 Nd07b82f65aa44fa5a5544b0d39dd9f95 schema:name readcube_id
123 schema:value 83f7c5d80767708e6ed17db5c91f802f2de62852616dbd835c3061c55f3b39a3
124 rdf:type schema:PropertyValue
125 Nd2a972283f504dcabfb718229146a56d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Central Nervous System Depressants
127 rdf:type schema:DefinedTerm
128 Nd6884f02436945d5b3b2effed592f20d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Substance-Related Disorders
130 rdf:type schema:DefinedTerm
131 Nec353d8933754e158736533cd54e95fa schema:name doi
132 schema:value 10.1007/bf00426372
133 rdf:type schema:PropertyValue
134 Nf478af17bc9c47adac98f402a958960f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Dose-Response Relationship, Drug
136 rdf:type schema:DefinedTerm
137 Nf5c3678d2c0340a4b0e2be8dae47feec schema:name Springer Nature - SN SciGraph project
138 rdf:type schema:Organization
139 Nf9b13d8958784cc18e50cb07e980f384 rdf:first sg:person.0666013665.33
140 rdf:rest N83b48d740fb74dc5969229a345a0cd29
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
145 schema:name Pharmacology and Pharmaceutical Sciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1085440 schema:issn 0033-3158
148 1432-2072
149 schema:name Psychopharmacology
150 rdf:type schema:Periodical
151 sg:person.01002242265.30 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
152 schema:familyName Cooper
153 schema:givenName Murray M.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002242265.30
155 rdf:type schema:Person
156 sg:person.0666013665.33 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
157 schema:familyName Collins
158 schema:givenName R. James
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666013665.33
160 rdf:type schema:Person
161 sg:person.0734127065.23 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
162 schema:familyName Weeks
163 schema:givenName James R.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734127065.23
165 rdf:type schema:Person
166 sg:pub.10.1007/bf00405254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028425305
167 https://doi.org/10.1007/bf00405254
168 rdf:type schema:CreativeWork
169 sg:pub.10.1007/bf00433045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053322650
170 https://doi.org/10.1007/bf00433045
171 rdf:type schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1079901493 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1081682628 schema:CreativeWork
174 https://doi.org/10.1002/cpt1979255part1611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051924375
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0028-3908(79)90160-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040757517
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/0090-6980(79)90002-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033039198
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/0091-3057(77)90254-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021357170
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/0091-3057(81)90319-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001504902
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/0091-3057(82)90033-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014458365
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/b978-0-12-004702-4.50010-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033582076
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/b978-0-12-512302-0.50010-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032055514
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0031-6989(74)80039-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012940383
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0090-6980(76)80003-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038026363
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1093/biomet/52.3-4.591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059417484
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1126/science.138.3537.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062478263
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1146/annurev.pa.09.040169.002411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029187794
199 rdf:type schema:CreativeWork
200 https://www.grid.ac/institutes/grid.410513.2 schema:alternateName Pfizer (United States)
201 schema:name Departments of CNS Research, Cardiovascular Diseases Research, and Department of Biostatistics, The Upjohn Company, 49001, Kalamazoo, MI, USA
202 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...