Regulation of cephalosporin synthesis in Cephalosporium acremonium by phosphate and glucose View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-11

AUTHORS

Martin T. Küenzi

ABSTRACT

The regulation of cephalosporin synthesis in Cephalosporium acremonium was studied in a simple chemically-defined medium with glucose as the carbon source. Antibiotic synthesis depended on the phosphate content of the medium. At phosphate concentrations above 2.75 mM maximum antibiotic titres were not reached while glucose uptake and growth rates were increased. Phosphate exerted its effect indirectly by regulating the rate of glucose consumption. The negative effect of high phosphate concentrations could be overcome completely by controlling the sugar supply in fed-batch and chemostat experiments. High actual concentrations of phosphate or of glucose alone had no direct negative effect on antibiotic synthesis. More... »

PAGES

78-83

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00422309

DOI

http://dx.doi.org/10.1007/bf00422309

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019493501

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7192969


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Organic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acremonium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carbohydrate Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cephalosporins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fermentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphates", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Research Laboratories of the Pharmaceutical Division of CIBA-Geigy Limited, CH-4002, Basle, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00fcenzi", 
        "givenName": "Martin T.", 
        "id": "sg:person.011261571425.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011261571425.10"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00942209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002036445", 
          "https://doi.org/10.1007/bf00942209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1030877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003252878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj1030877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003252878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/m69-029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011533434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.14.2.159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021165860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(75)43133-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021798322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0147-5975(78)80016-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021861096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.1977.tb00933.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037085233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1574-6968.1977.tb00933.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037085233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2164-0947.1963.tb01914.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039004241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/3-540-08363-4_4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039433631", 
          "https://doi.org/10.1007/3-540-08363-4_4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00394127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044501139", 
          "https://doi.org/10.1007/bf00394127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00394127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044501139", 
          "https://doi.org/10.1007/bf00394127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00406371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053295241", 
          "https://doi.org/10.1007/bf00406371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00406371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053295241", 
          "https://doi.org/10.1007/bf00406371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ie50520a056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055633506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7164/antibiotics.26.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073629489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7164/antibiotics.28.881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073629972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076941581", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077159732", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081243152", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1980-11", 
    "datePublishedReg": "1980-11-01", 
    "description": "The regulation of cephalosporin synthesis in Cephalosporium acremonium was studied in a simple chemically-defined medium with glucose as the carbon source. Antibiotic synthesis depended on the phosphate content of the medium. At phosphate concentrations above 2.75 mM maximum antibiotic titres were not reached while glucose uptake and growth rates were increased. Phosphate exerted its effect indirectly by regulating the rate of glucose consumption. The negative effect of high phosphate concentrations could be overcome completely by controlling the sugar supply in fed-batch and chemostat experiments. High actual concentrations of phosphate or of glucose alone had no direct negative effect on antibiotic synthesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00422309", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018945", 
        "issn": [
          "0302-8933", 
          "1432-072X"
        ], 
        "name": "Archives of Microbiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "128"
      }
    ], 
    "name": "Regulation of cephalosporin synthesis in Cephalosporium acremonium by phosphate and glucose", 
    "pagination": "78-83", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00422309"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5ce1603b8802d3033da3c4c1a9595d28c5e742d972d6707c826399d6f4bd68f3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1019493501"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410427"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7192969"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00422309", 
      "https://app.dimensions.ai/details/publication/pub.1019493501"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000375_0000000375/records_91469_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00422309"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00422309'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00422309'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00422309'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00422309'


 

This table displays all metadata directly associated to this object as RDF triples.

148 TRIPLES      21 PREDICATES      53 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00422309 schema:about N0eeb2950e5e946feb32556035fda5776
2 N12a9bc7e198e449eb605745532456630
3 N2172fb7715514be19598bfad702e78e8
4 N2d2969e78e6849a0bb8356f2e9472d73
5 N32eedb42a4d8418a82bbbd8ba84805ab
6 Nd1e10e5fa122412c9f991bfead851f20
7 Nf222c103e84947c291e284ba3faca394
8 anzsrc-for:03
9 anzsrc-for:0305
10 schema:author Ncb5d1fd762074ca197731863e5b612fb
11 schema:citation sg:pub.10.1007/3-540-08363-4_4
12 sg:pub.10.1007/bf00394127
13 sg:pub.10.1007/bf00406371
14 sg:pub.10.1007/bf00942209
15 https://app.dimensions.ai/details/publication/pub.1076941581
16 https://app.dimensions.ai/details/publication/pub.1077159732
17 https://app.dimensions.ai/details/publication/pub.1081243152
18 https://doi.org/10.1016/0076-6879(75)43133-0
19 https://doi.org/10.1016/s0147-5975(78)80016-4
20 https://doi.org/10.1021/ie50520a056
21 https://doi.org/10.1042/bj1030877
22 https://doi.org/10.1111/j.1574-6968.1977.tb00933.x
23 https://doi.org/10.1111/j.2164-0947.1963.tb01914.x
24 https://doi.org/10.1128/aac.14.2.159
25 https://doi.org/10.1139/m69-029
26 https://doi.org/10.7164/antibiotics.26.135
27 https://doi.org/10.7164/antibiotics.28.881
28 schema:datePublished 1980-11
29 schema:datePublishedReg 1980-11-01
30 schema:description The regulation of cephalosporin synthesis in Cephalosporium acremonium was studied in a simple chemically-defined medium with glucose as the carbon source. Antibiotic synthesis depended on the phosphate content of the medium. At phosphate concentrations above 2.75 mM maximum antibiotic titres were not reached while glucose uptake and growth rates were increased. Phosphate exerted its effect indirectly by regulating the rate of glucose consumption. The negative effect of high phosphate concentrations could be overcome completely by controlling the sugar supply in fed-batch and chemostat experiments. High actual concentrations of phosphate or of glucose alone had no direct negative effect on antibiotic synthesis.
31 schema:genre research_article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N639b22bb6e4c4d34bfee55052817ae4f
35 N8b92a309ef3a4607bbb977df43c8a089
36 sg:journal.1018945
37 schema:name Regulation of cephalosporin synthesis in Cephalosporium acremonium by phosphate and glucose
38 schema:pagination 78-83
39 schema:productId N2ef2eceb0357430fa35badd5bb4b0b44
40 Nad672710cb334b38a7ae3ac8727717a7
41 Nb19e3c6ed34f4fd4be0c68b3982f8ac2
42 Nc7fb189a2be348dfa9ed1ca6f412b662
43 Nf09cd32a1fd74ce5bd14bd6c0c34d029
44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019493501
45 https://doi.org/10.1007/bf00422309
46 schema:sdDatePublished 2019-04-15T09:04
47 schema:sdLicense https://scigraph.springernature.com/explorer/license/
48 schema:sdPublisher N81a9e39c991a4536a9899b6e0f18aa6d
49 schema:url http://link.springer.com/10.1007/BF00422309
50 sgo:license sg:explorer/license/
51 sgo:sdDataset articles
52 rdf:type schema:ScholarlyArticle
53 N0eeb2950e5e946feb32556035fda5776 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
54 schema:name Acremonium
55 rdf:type schema:DefinedTerm
56 N12a9bc7e198e449eb605745532456630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Glucose
58 rdf:type schema:DefinedTerm
59 N2172fb7715514be19598bfad702e78e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Carbohydrate Metabolism
61 rdf:type schema:DefinedTerm
62 N2d2969e78e6849a0bb8356f2e9472d73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Phosphates
64 rdf:type schema:DefinedTerm
65 N2ef2eceb0357430fa35badd5bb4b0b44 schema:name nlm_unique_id
66 schema:value 0410427
67 rdf:type schema:PropertyValue
68 N32eedb42a4d8418a82bbbd8ba84805ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Cephalosporins
70 rdf:type schema:DefinedTerm
71 N3ded77c386ce43418b11594f640e6c98 schema:name Research Laboratories of the Pharmaceutical Division of CIBA-Geigy Limited, CH-4002, Basle, Switzerland
72 rdf:type schema:Organization
73 N639b22bb6e4c4d34bfee55052817ae4f schema:volumeNumber 128
74 rdf:type schema:PublicationVolume
75 N81a9e39c991a4536a9899b6e0f18aa6d schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 N8b92a309ef3a4607bbb977df43c8a089 schema:issueNumber 1
78 rdf:type schema:PublicationIssue
79 Nad672710cb334b38a7ae3ac8727717a7 schema:name doi
80 schema:value 10.1007/bf00422309
81 rdf:type schema:PropertyValue
82 Nb19e3c6ed34f4fd4be0c68b3982f8ac2 schema:name readcube_id
83 schema:value 5ce1603b8802d3033da3c4c1a9595d28c5e742d972d6707c826399d6f4bd68f3
84 rdf:type schema:PropertyValue
85 Nc7fb189a2be348dfa9ed1ca6f412b662 schema:name dimensions_id
86 schema:value pub.1019493501
87 rdf:type schema:PropertyValue
88 Ncb5d1fd762074ca197731863e5b612fb rdf:first sg:person.011261571425.10
89 rdf:rest rdf:nil
90 Nd1e10e5fa122412c9f991bfead851f20 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Biological Transport
92 rdf:type schema:DefinedTerm
93 Nf09cd32a1fd74ce5bd14bd6c0c34d029 schema:name pubmed_id
94 schema:value 7192969
95 rdf:type schema:PropertyValue
96 Nf222c103e84947c291e284ba3faca394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Fermentation
98 rdf:type schema:DefinedTerm
99 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
100 schema:name Chemical Sciences
101 rdf:type schema:DefinedTerm
102 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
103 schema:name Organic Chemistry
104 rdf:type schema:DefinedTerm
105 sg:journal.1018945 schema:issn 0302-8933
106 1432-072X
107 schema:name Archives of Microbiology
108 rdf:type schema:Periodical
109 sg:person.011261571425.10 schema:affiliation N3ded77c386ce43418b11594f640e6c98
110 schema:familyName Küenzi
111 schema:givenName Martin T.
112 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011261571425.10
113 rdf:type schema:Person
114 sg:pub.10.1007/3-540-08363-4_4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039433631
115 https://doi.org/10.1007/3-540-08363-4_4
116 rdf:type schema:CreativeWork
117 sg:pub.10.1007/bf00394127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044501139
118 https://doi.org/10.1007/bf00394127
119 rdf:type schema:CreativeWork
120 sg:pub.10.1007/bf00406371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053295241
121 https://doi.org/10.1007/bf00406371
122 rdf:type schema:CreativeWork
123 sg:pub.10.1007/bf00942209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002036445
124 https://doi.org/10.1007/bf00942209
125 rdf:type schema:CreativeWork
126 https://app.dimensions.ai/details/publication/pub.1076941581 schema:CreativeWork
127 https://app.dimensions.ai/details/publication/pub.1077159732 schema:CreativeWork
128 https://app.dimensions.ai/details/publication/pub.1081243152 schema:CreativeWork
129 https://doi.org/10.1016/0076-6879(75)43133-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021798322
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1016/s0147-5975(78)80016-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021861096
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1021/ie50520a056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055633506
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1042/bj1030877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003252878
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1111/j.1574-6968.1977.tb00933.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037085233
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1111/j.2164-0947.1963.tb01914.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039004241
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1128/aac.14.2.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021165860
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1139/m69-029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011533434
144 rdf:type schema:CreativeWork
145 https://doi.org/10.7164/antibiotics.26.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073629489
146 rdf:type schema:CreativeWork
147 https://doi.org/10.7164/antibiotics.28.881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073629972
148 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...