Ontology type: schema:ScholarlyArticle Open Access: True
1994-11
AUTHORSS. M. Brichard, L. N. Ongemba, J. Girard, J. C. Henquin
ABSTRACTVanadium is a potent insulinomimetic agent. In vivo, its blood glucose lowering action in insulin-deficient diabetic rats is associated with corrected expression of genes involved in hepatic glucose metabolism. In this study, we investigated whether vanadate treatment also reverses the impaired expression of genes coding for key enzymes of lipogenesis in diabetic liver and white adipose tissue. Oral administration of vanadate to streptozotocin-rats caused a 55% fall in plasma glucose levels after feeding without modifying low insulinaemia. It also partially corrected the low thyroid hormone concentrations. In untreated diabetic animals, hepatic mRNA levels of acetyl-CoA carboxylase and fatty acid synthase were reduced by more than 80 and 90%, respectively, in close correlation with changes in enzyme activities. Three weeks of vanadate treatment totally restored acetyl-CoA carboxylase mRNA and partially restored fatty acid synthase mRNA (71% of control levels). The activities of both lipogenic enzymes were increased 3.5 to 4-fold, to reach 45 to 65% of control values. By contrast, in white adipose tissue, vanadate modified neither expression nor activity of both lipogenic enzymes, which remained blunted (< 10% of control levels). In conclusion, vanadate treatment partially restores the activities of two key lipogenic enzymes in liver, but not in white adipose tissue, of diabetic rats. This correction results from a reversal of impaired pre-translational regulatory mechanisms possibly mediated by an improvement of thyroid function and a selective restoration of liver glycolytic flux. More... »
PAGES1065-1072
http://scigraph.springernature.com/pub.10.1007/bf00418369
DOIhttp://dx.doi.org/10.1007/bf00418369
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1026003442
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7867878
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Acetyl-CoA Carboxylase",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adipose Tissue",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Administration, Oral",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diabetes Mellitus, Experimental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fatty Acid Synthases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Enzymologic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lipid Metabolism",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Wistar",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thyroid Hormones",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vanadates",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Universit\u00e9 Catholique de Louvain",
"id": "https://www.grid.ac/institutes/grid.7942.8",
"name": [
"Faculty of Medicine, Unit\u00e9 d'Endocrinologie et M\u00e9tabolisme, University of Louvain, Brussels, Belgium"
],
"type": "Organization"
},
"familyName": "Brichard",
"givenName": "S. M.",
"id": "sg:person.0644052427.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644052427.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universit\u00e9 Catholique de Louvain",
"id": "https://www.grid.ac/institutes/grid.7942.8",
"name": [
"Faculty of Medicine, Unit\u00e9 d'Endocrinologie et M\u00e9tabolisme, University of Louvain, Brussels, Belgium"
],
"type": "Organization"
},
"familyName": "Ongemba",
"givenName": "L. N.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "D\u00e9l\u00e9gation Ile-de-France Ouest et Nord",
"id": "https://www.grid.ac/institutes/grid.433123.4",
"name": [
"CNRS, Meudon, France"
],
"type": "Organization"
},
"familyName": "Girard",
"givenName": "J.",
"id": "sg:person.0723343263.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723343263.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universit\u00e9 Catholique de Louvain",
"id": "https://www.grid.ac/institutes/grid.7942.8",
"name": [
"Faculty of Medicine, Unit\u00e9 d'Endocrinologie et M\u00e9tabolisme, University of Louvain, Brussels, Belgium"
],
"type": "Organization"
},
"familyName": "Henquin",
"givenName": "J. C.",
"id": "sg:person.0666465205.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666465205.68"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/0303-7207(93)90259-m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002163217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0303-7207(93)90259-m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002163217"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0083-6729(08)60895-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003168835"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj2020791",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005342440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj2020791",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005342440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0005-2760(75)90113-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008007335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0005-2760(75)90113-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008007335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0168-8227(93)90113-j",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010221310"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.80.12.3656",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011797960"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-2697(87)90021-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013321498"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci116580",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016607575"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016989689",
"https://doi.org/10.1007/bf00400924"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016989689",
"https://doi.org/10.1007/bf00400924"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400924",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016989689",
"https://doi.org/10.1007/bf00400924"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1990.tb15592.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018300799"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-9861(81)90320-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020729741"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00925740",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023343059",
"https://doi.org/10.1007/bf00925740"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.71.3.889",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023503761"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01219324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023978583",
"https://doi.org/10.1007/bf01219324"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01219324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023978583",
"https://doi.org/10.1007/bf01219324"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01219324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023978583",
"https://doi.org/10.1007/bf01219324"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-9861(88)90013-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025155574"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-2697(76)90527-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025529346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-2999(92)90219-t",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025828686"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-2999(92)90219-t",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025828686"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1984.tb08122.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027388961"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00265092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030487396",
"https://doi.org/10.1007/bf00265092"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00265092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030487396",
"https://doi.org/10.1007/bf00265092"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00265092",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030487396",
"https://doi.org/10.1007/bf00265092"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci115988",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030690418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1992.tb16797.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030801817"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400477",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031679408",
"https://doi.org/10.1007/bf00400477"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400477",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031679408",
"https://doi.org/10.1007/bf00400477"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400477",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031679408",
"https://doi.org/10.1007/bf00400477"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-1033.1990.tb15593.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034286580"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-9861(90)90616-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037773482"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00399953",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040156991",
"https://doi.org/10.1007/bf00399953"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00399953",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040156991",
"https://doi.org/10.1007/bf00399953"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00399953",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040156991",
"https://doi.org/10.1007/bf00399953"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-2697(80)90165-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041047483"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400230",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043076797",
"https://doi.org/10.1007/bf00400230"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400230",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043076797",
"https://doi.org/10.1007/bf00400230"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00400230",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043076797",
"https://doi.org/10.1007/bf00400230"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0026-0495(92)90154-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048170501"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1439783",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062482232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.3156405",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062594854"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo-114-4-1358",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064257915"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo-122-5-2285",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064261421"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo-123-4-2048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064261833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo-125-5-2510",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064262839"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo-127-6-2716",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064263808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diab.37.9.1234",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070735600"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diacare.39.1.1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070749172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/oxfordjournals.jbchem.a123713",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075797869"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075842772",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077422670",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077843044",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078408299",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078415567",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078818452",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079039924",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpheart.1989.257.3.h904",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079209813"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079413775",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079473233",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081436928",
"type": "CreativeWork"
}
],
"datePublished": "1994-11",
"datePublishedReg": "1994-11-01",
"description": "Vanadium is a potent insulinomimetic agent. In vivo, its blood glucose lowering action in insulin-deficient diabetic rats is associated with corrected expression of genes involved in hepatic glucose metabolism. In this study, we investigated whether vanadate treatment also reverses the impaired expression of genes coding for key enzymes of lipogenesis in diabetic liver and white adipose tissue. Oral administration of vanadate to streptozotocin-rats caused a 55% fall in plasma glucose levels after feeding without modifying low insulinaemia. It also partially corrected the low thyroid hormone concentrations. In untreated diabetic animals, hepatic mRNA levels of acetyl-CoA carboxylase and fatty acid synthase were reduced by more than 80 and 90%, respectively, in close correlation with changes in enzyme activities. Three weeks of vanadate treatment totally restored acetyl-CoA carboxylase mRNA and partially restored fatty acid synthase mRNA (71% of control levels). The activities of both lipogenic enzymes were increased 3.5 to 4-fold, to reach 45 to 65% of control values. By contrast, in white adipose tissue, vanadate modified neither expression nor activity of both lipogenic enzymes, which remained blunted (< 10% of control levels). In conclusion, vanadate treatment partially restores the activities of two key lipogenic enzymes in liver, but not in white adipose tissue, of diabetic rats. This correction results from a reversal of impaired pre-translational regulatory mechanisms possibly mediated by an improvement of thyroid function and a selective restoration of liver glycolytic flux.",
"genre": "research_article",
"id": "sg:pub.10.1007/bf00418369",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1001482",
"issn": [
"0012-186X",
"1432-0428"
],
"name": "Diabetologia",
"type": "Periodical"
},
{
"issueNumber": "11",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "37"
}
],
"name": "Tissue-specific correction of lipogenic enzyme gene expression in diabetic rats given vanadate",
"pagination": "1065-1072",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"7be13756e93817a5ab391f8505942d1ab60ac2378684f19d2ed95bc1b41bb3a3"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"7867878"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0006777"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf00418369"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1026003442"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf00418369",
"https://app.dimensions.ai/details/publication/pub.1026003442"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:48",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130793_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2FBF00418369"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00418369'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00418369'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00418369'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00418369'
This table displays all metadata directly associated to this object as RDF triples.
300 TRIPLES
21 PREDICATES
94 URIs
37 LITERALS
25 BLANK NODES