Angiotensinase A gene expression and enzyme activity in isolated glomeruli of diabetic rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-03

AUTHORS

F. Thaiss, G. Wolf, N. Assad, G. Zahner, R. A. K. Stahl

ABSTRACT

One of the characteristics of early diabetic nephropathy is glomerular hyperfiltration and hyperperfusion. Many factors have been suggested to induce glomerular hyperperfusion among which are an increased production of vasodilatory prostanoids, an increased synthesis of nitric oxide, a reduced responsiveness of afferent glomerular arterioles to vasoconstrictor stimuli due to diabetic metabolic disturbances and a decreased receptor density for angiotensin II. It has been known for years that angiotensin II is formed locally due to the local activation of the renin angiotensin system. The local angiotensin II concentration, however, is not only regulated by the synthesis rate but also by the local degradation through activation of an aminopeptidase. The main finding of the present study was that the mRNA expression and activity of the angiotensin II degrading enzyme, angiotensinase A, was increased twofold in diabetic rats at 5 weeks and that the increase in mRNA expression was suppressed by insulin therapy and short-term treatment with the angiotensin II antagonist saralasin, whereas angiotensinase A enzyme activity was only reduced by saralasin and not by insulin. These results demonstrate that the angiotensin II degrading exopeptidase angiotensinase A is activated in diabetic glomeruli. This increased activity may be an additional mechanism to explain glomerular hyperfiltration and hyperperfusion in early diabetic nephropathy. More... »

PAGES

275-280

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00418342

DOI

http://dx.doi.org/10.1007/bf00418342

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043451089

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8721772


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Albuminuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aminopeptidases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Northern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerular Filtration Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamyl Aminopeptidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Size", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saralasin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Internal Medicine, Division of Nephrology, University Hospital, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thaiss", 
        "givenName": "F.", 
        "id": "sg:person.01024637706.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024637706.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Internal Medicine, Division of Nephrology, University Hospital, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolf", 
        "givenName": "G.", 
        "id": "sg:person.01334335003.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334335003.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Frankfurt", 
          "id": "https://www.grid.ac/institutes/grid.411088.4", 
          "name": [
            "Department of Internal Medicine, Division of Nephrology, University Hospital, Frankfurt am Main, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Assad", 
        "givenName": "N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Internal Medicine, Division of Nephrology, University Hospital, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zahner", 
        "givenName": "G.", 
        "id": "sg:person.0730273766.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730273766.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Department of Internal Medicine, Division of Nephrology, University Hospital, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stahl", 
        "givenName": "R. A. K.", 
        "id": "sg:person.07531646362.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531646362.07"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00400475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003283156", 
          "https://doi.org/10.1007/bf00400475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003283156", 
          "https://doi.org/10.1007/bf00400475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00400475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003283156", 
          "https://doi.org/10.1007/bf00400475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1991.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003776872", 
          "https://doi.org/10.1038/ki.1991.277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007466471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00684380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007938061", 
          "https://doi.org/10.1007/bf00684380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00684380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007938061", 
          "https://doi.org/10.1007/bf00684380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1991.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008465118", 
          "https://doi.org/10.1038/ki.1991.249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.19.5.464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013819874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1990.283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019086706", 
          "https://doi.org/10.1038/ki.1990.283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.4.1222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022822758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.19.1.70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027708398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/194867a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028560589", 
          "https://doi.org/10.1038/194867a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(92)90142-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028891771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1991.260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036637319", 
          "https://doi.org/10.1038/ki.1991.260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037103084", 
          "https://doi.org/10.1038/ki.1992.227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037489895", 
          "https://doi.org/10.1038/ki.1994.52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038018661", 
          "https://doi.org/10.1038/ki.1989.10"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(12)80439-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043606866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.2.676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045136389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049307690", 
          "https://doi.org/10.1038/ki.1994.458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050327106", 
          "https://doi.org/10.1038/ki.1992.123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-120-4-1291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064260501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077264696", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078423205", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078453741", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1984.247.1.f110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081682932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1984.247.6.f975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081784756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082665180", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082665181", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1993.265.4.f477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082716914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082836715", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082871745", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-03", 
    "datePublishedReg": "1996-03-01", 
    "description": "One of the characteristics of early diabetic nephropathy is glomerular hyperfiltration and hyperperfusion. Many factors have been suggested to induce glomerular hyperperfusion among which are an increased production of vasodilatory prostanoids, an increased synthesis of nitric oxide, a reduced responsiveness of afferent glomerular arterioles to vasoconstrictor stimuli due to diabetic metabolic disturbances and a decreased receptor density for angiotensin II. It has been known for years that angiotensin II is formed locally due to the local activation of the renin angiotensin system. The local angiotensin II concentration, however, is not only regulated by the synthesis rate but also by the local degradation through activation of an aminopeptidase. The main finding of the present study was that the mRNA expression and activity of the angiotensin II degrading enzyme, angiotensinase A, was increased twofold in diabetic rats at 5 weeks and that the increase in mRNA expression was suppressed by insulin therapy and short-term treatment with the angiotensin II antagonist saralasin, whereas angiotensinase A enzyme activity was only reduced by saralasin and not by insulin. These results demonstrate that the angiotensin II degrading exopeptidase angiotensinase A is activated in diabetic glomeruli. This increased activity may be an additional mechanism to explain glomerular hyperfiltration and hyperperfusion in early diabetic nephropathy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00418342", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Angiotensinase A gene expression and enzyme activity in isolated glomeruli of diabetic rats", 
    "pagination": "275-280", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cef9521d0bc05ef84e305486973fedb40994f3900c5b34c216043ecab5b56c32"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8721772"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00418342"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1043451089"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00418342", 
      "https://app.dimensions.ai/details/publication/pub.1043451089"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130811_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/BF00418342"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00418342'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00418342'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00418342'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00418342'


 

This table displays all metadata directly associated to this object as RDF triples.

286 TRIPLES      21 PREDICATES      82 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00418342 schema:about N027967f5683644c2a7f8a2d66d6a0dd6
2 N0e828364107747049623237df1ff45d3
3 N128cb4e919fd498dafd096d4c90c0738
4 N3e8249cc7a854ec3a3d2ec88d5053b87
5 N461980d02b214261a4ff8f464e88d64c
6 N65aee27f212842818e440ce5d00790cd
7 N6bf32da9a71743a4a3ae9721e9781a4d
8 N6f12574aaffb4f08a12146cfb79a7b21
9 N75a828a0a512409f8c96a61417c6df07
10 N8fab707342cd4396a9e61605346c7cb6
11 N9304ea91f3f54b7f8757a5f07c400677
12 Nabd107a33ffe4449b9b0cb76e4ec07bc
13 Nac1318f3f874419b986aceac55beb808
14 Nb0d049a660bd44898952bc2390618bc7
15 Nb834894604764ed7a2ff5e5480ea5d77
16 Nbc6c550b672a4b7e816fb850bf21bd25
17 Nc917336b1fc34321a600ae84de38e543
18 Ncdb46514acd24bc8967ab3aabdc31dd4
19 Ndd826772c74d475dacbec56d3d142c25
20 Ne2d9fc10c8c64c75af2eeb3a819b279a
21 Ne9d784688524436f96b9d53fb9681f04
22 Nf8deced8f5674050a1038bb61c1681e7
23 Nfb2d22c684f5485da633267f3aa6cb4c
24 anzsrc-for:11
25 anzsrc-for:1103
26 schema:author N9f1141828d864acbb63f3854b57c6215
27 schema:citation sg:pub.10.1007/bf00400475
28 sg:pub.10.1007/bf00684380
29 sg:pub.10.1038/194867a0
30 sg:pub.10.1038/ki.1989.10
31 sg:pub.10.1038/ki.1990.283
32 sg:pub.10.1038/ki.1991.249
33 sg:pub.10.1038/ki.1991.260
34 sg:pub.10.1038/ki.1991.277
35 sg:pub.10.1038/ki.1992.123
36 sg:pub.10.1038/ki.1992.227
37 sg:pub.10.1038/ki.1994.458
38 sg:pub.10.1038/ki.1994.52
39 https://app.dimensions.ai/details/publication/pub.1077264696
40 https://app.dimensions.ai/details/publication/pub.1078423205
41 https://app.dimensions.ai/details/publication/pub.1078453741
42 https://app.dimensions.ai/details/publication/pub.1082665180
43 https://app.dimensions.ai/details/publication/pub.1082665181
44 https://app.dimensions.ai/details/publication/pub.1082836715
45 https://app.dimensions.ai/details/publication/pub.1082871745
46 https://doi.org/10.1016/0002-9343(92)90142-x
47 https://doi.org/10.1016/s0272-6386(12)80439-2
48 https://doi.org/10.1073/pnas.88.2.676
49 https://doi.org/10.1073/pnas.90.4.1222
50 https://doi.org/10.1152/ajprenal.1984.247.1.f110
51 https://doi.org/10.1152/ajprenal.1984.247.6.f975
52 https://doi.org/10.1152/ajprenal.1993.265.4.f477
53 https://doi.org/10.1161/01.hyp.19.1.70
54 https://doi.org/10.1161/01.hyp.19.5.464
55 https://doi.org/10.1172/jci115179
56 https://doi.org/10.1210/endo-120-4-1291
57 schema:datePublished 1996-03
58 schema:datePublishedReg 1996-03-01
59 schema:description One of the characteristics of early diabetic nephropathy is glomerular hyperfiltration and hyperperfusion. Many factors have been suggested to induce glomerular hyperperfusion among which are an increased production of vasodilatory prostanoids, an increased synthesis of nitric oxide, a reduced responsiveness of afferent glomerular arterioles to vasoconstrictor stimuli due to diabetic metabolic disturbances and a decreased receptor density for angiotensin II. It has been known for years that angiotensin II is formed locally due to the local activation of the renin angiotensin system. The local angiotensin II concentration, however, is not only regulated by the synthesis rate but also by the local degradation through activation of an aminopeptidase. The main finding of the present study was that the mRNA expression and activity of the angiotensin II degrading enzyme, angiotensinase A, was increased twofold in diabetic rats at 5 weeks and that the increase in mRNA expression was suppressed by insulin therapy and short-term treatment with the angiotensin II antagonist saralasin, whereas angiotensinase A enzyme activity was only reduced by saralasin and not by insulin. These results demonstrate that the angiotensin II degrading exopeptidase angiotensinase A is activated in diabetic glomeruli. This increased activity may be an additional mechanism to explain glomerular hyperfiltration and hyperperfusion in early diabetic nephropathy.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N0b573e6d8aa643429698d731e6c9b8e9
64 N1778fd97857a40df93a6b3c2e5794fe7
65 sg:journal.1001482
66 schema:name Angiotensinase A gene expression and enzyme activity in isolated glomeruli of diabetic rats
67 schema:pagination 275-280
68 schema:productId N4f6b856ae7234deb950426c20ae71011
69 Nb02c6f2fa8514d89bf9fcc36218cc878
70 Nc7023657fd894f66a03e62f9ce715a0e
71 Nd335029d12954c7d83246f0e87c6c268
72 Ne2f3193cb6fd4cc992870243dd7efe16
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043451089
74 https://doi.org/10.1007/bf00418342
75 schema:sdDatePublished 2019-04-11T13:54
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N72c99427b52b44958bd7cd53e248246f
78 schema:url http://link.springer.com/10.1007/BF00418342
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N02659e5044af440fb2349ba893684984 rdf:first sg:person.01334335003.33
83 rdf:rest N2fda4809b4c3411997be5537b2dea93f
84 N027967f5683644c2a7f8a2d66d6a0dd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Blood Glucose
86 rdf:type schema:DefinedTerm
87 N0b573e6d8aa643429698d731e6c9b8e9 schema:issueNumber 3
88 rdf:type schema:PublicationIssue
89 N0e828364107747049623237df1ff45d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Angiotensin II
91 rdf:type schema:DefinedTerm
92 N128cb4e919fd498dafd096d4c90c0738 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Kidney Glomerulus
94 rdf:type schema:DefinedTerm
95 N1778fd97857a40df93a6b3c2e5794fe7 schema:volumeNumber 39
96 rdf:type schema:PublicationVolume
97 N2fda4809b4c3411997be5537b2dea93f rdf:first N5b5fc3ad1b8f46eaa9bc4fd928d4715d
98 rdf:rest Nd99bf3321c404538abc2b3bb564a761f
99 N3e8249cc7a854ec3a3d2ec88d5053b87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Body Weight
101 rdf:type schema:DefinedTerm
102 N461980d02b214261a4ff8f464e88d64c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Kidney
104 rdf:type schema:DefinedTerm
105 N4ed7a9ce3b514e21b2d1a83b2938a023 rdf:first sg:person.07531646362.07
106 rdf:rest rdf:nil
107 N4f6b856ae7234deb950426c20ae71011 schema:name pubmed_id
108 schema:value 8721772
109 rdf:type schema:PropertyValue
110 N5b5fc3ad1b8f46eaa9bc4fd928d4715d schema:affiliation https://www.grid.ac/institutes/grid.411088.4
111 schema:familyName Assad
112 schema:givenName N.
113 rdf:type schema:Person
114 N65aee27f212842818e440ce5d00790cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Glutamyl Aminopeptidase
116 rdf:type schema:DefinedTerm
117 N6bf32da9a71743a4a3ae9721e9781a4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Rats, Wistar
119 rdf:type schema:DefinedTerm
120 N6f12574aaffb4f08a12146cfb79a7b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Male
122 rdf:type schema:DefinedTerm
123 N72c99427b52b44958bd7cd53e248246f schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N75a828a0a512409f8c96a61417c6df07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Animals
127 rdf:type schema:DefinedTerm
128 N8fab707342cd4396a9e61605346c7cb6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Glomerular Filtration Rate
130 rdf:type schema:DefinedTerm
131 N9304ea91f3f54b7f8757a5f07c400677 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Immunohistochemistry
133 rdf:type schema:DefinedTerm
134 N9f1141828d864acbb63f3854b57c6215 rdf:first sg:person.01024637706.17
135 rdf:rest N02659e5044af440fb2349ba893684984
136 Nabd107a33ffe4449b9b0cb76e4ec07bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Saralasin
138 rdf:type schema:DefinedTerm
139 Nac1318f3f874419b986aceac55beb808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Rats
141 rdf:type schema:DefinedTerm
142 Nb02c6f2fa8514d89bf9fcc36218cc878 schema:name nlm_unique_id
143 schema:value 0006777
144 rdf:type schema:PropertyValue
145 Nb0d049a660bd44898952bc2390618bc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Organ Size
147 rdf:type schema:DefinedTerm
148 Nb834894604764ed7a2ff5e5480ea5d77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Albuminuria
150 rdf:type schema:DefinedTerm
151 Nbc6c550b672a4b7e816fb850bf21bd25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Insulin
153 rdf:type schema:DefinedTerm
154 Nc7023657fd894f66a03e62f9ce715a0e schema:name doi
155 schema:value 10.1007/bf00418342
156 rdf:type schema:PropertyValue
157 Nc917336b1fc34321a600ae84de38e543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Time Factors
159 rdf:type schema:DefinedTerm
160 Ncdb46514acd24bc8967ab3aabdc31dd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Gene Expression
162 rdf:type schema:DefinedTerm
163 Nd335029d12954c7d83246f0e87c6c268 schema:name dimensions_id
164 schema:value pub.1043451089
165 rdf:type schema:PropertyValue
166 Nd99bf3321c404538abc2b3bb564a761f rdf:first sg:person.0730273766.64
167 rdf:rest N4ed7a9ce3b514e21b2d1a83b2938a023
168 Ndd826772c74d475dacbec56d3d142c25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Blotting, Northern
170 rdf:type schema:DefinedTerm
171 Ne2d9fc10c8c64c75af2eeb3a819b279a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name In Vitro Techniques
173 rdf:type schema:DefinedTerm
174 Ne2f3193cb6fd4cc992870243dd7efe16 schema:name readcube_id
175 schema:value cef9521d0bc05ef84e305486973fedb40994f3900c5b34c216043ecab5b56c32
176 rdf:type schema:PropertyValue
177 Ne9d784688524436f96b9d53fb9681f04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Diabetes Mellitus, Experimental
179 rdf:type schema:DefinedTerm
180 Nf8deced8f5674050a1038bb61c1681e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Aminopeptidases
182 rdf:type schema:DefinedTerm
183 Nfb2d22c684f5485da633267f3aa6cb4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Kinetics
185 rdf:type schema:DefinedTerm
186 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
187 schema:name Medical and Health Sciences
188 rdf:type schema:DefinedTerm
189 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
190 schema:name Clinical Sciences
191 rdf:type schema:DefinedTerm
192 sg:journal.1001482 schema:issn 0012-186X
193 1432-0428
194 schema:name Diabetologia
195 rdf:type schema:Periodical
196 sg:person.01024637706.17 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
197 schema:familyName Thaiss
198 schema:givenName F.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024637706.17
200 rdf:type schema:Person
201 sg:person.01334335003.33 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
202 schema:familyName Wolf
203 schema:givenName G.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334335003.33
205 rdf:type schema:Person
206 sg:person.0730273766.64 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
207 schema:familyName Zahner
208 schema:givenName G.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730273766.64
210 rdf:type schema:Person
211 sg:person.07531646362.07 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
212 schema:familyName Stahl
213 schema:givenName R. A. K.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531646362.07
215 rdf:type schema:Person
216 sg:pub.10.1007/bf00400475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003283156
217 https://doi.org/10.1007/bf00400475
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/bf00684380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007938061
220 https://doi.org/10.1007/bf00684380
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/194867a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028560589
223 https://doi.org/10.1038/194867a0
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ki.1989.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038018661
226 https://doi.org/10.1038/ki.1989.10
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/ki.1990.283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019086706
229 https://doi.org/10.1038/ki.1990.283
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ki.1991.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008465118
232 https://doi.org/10.1038/ki.1991.249
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/ki.1991.260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036637319
235 https://doi.org/10.1038/ki.1991.260
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/ki.1991.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003776872
238 https://doi.org/10.1038/ki.1991.277
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/ki.1992.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050327106
241 https://doi.org/10.1038/ki.1992.123
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/ki.1992.227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037103084
244 https://doi.org/10.1038/ki.1992.227
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/ki.1994.458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049307690
247 https://doi.org/10.1038/ki.1994.458
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/ki.1994.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037489895
250 https://doi.org/10.1038/ki.1994.52
251 rdf:type schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1077264696 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1078423205 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1078453741 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082665180 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082665181 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1082836715 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1082871745 schema:CreativeWork
259 https://doi.org/10.1016/0002-9343(92)90142-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028891771
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0272-6386(12)80439-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043606866
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1073/pnas.88.2.676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045136389
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1073/pnas.90.4.1222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022822758
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1152/ajprenal.1984.247.1.f110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081682932
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1152/ajprenal.1984.247.6.f975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081784756
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1152/ajprenal.1993.265.4.f477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082716914
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1161/01.hyp.19.1.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027708398
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1161/01.hyp.19.5.464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013819874
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1172/jci115179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007466471
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1210/endo-120-4-1291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064260501
280 rdf:type schema:CreativeWork
281 https://www.grid.ac/institutes/grid.13648.38 schema:alternateName University Medical Center Hamburg-Eppendorf
282 schema:name Department of Internal Medicine, Division of Nephrology, University Hospital, Hamburg, Germany
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.411088.4 schema:alternateName University Hospital Frankfurt
285 schema:name Department of Internal Medicine, Division of Nephrology, University Hospital, Frankfurt am Main, Germany
286 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...