Tumorhemmung durch Metallocene: Wirkung von Titanocen-, Zirconocen- und Hafnocen-dichlorid gegenüber Ehrlich-Aszites-Tumor der Maus View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1980-01

AUTHORS

P. Köpf-Maier, B. Hesse, H. Köpf

ABSTRACT

The antitumor activity of the metallocene dichlorides TDC, ZDC, and HDC against Ehrlich ascites tumor in CF 1 mice is investigated. A single i.p. injection of TDC in the optimum dose (30–60 mg/kg) 24 h p.t.t. achieves survival of 80–90% of the animals until day 180 p.t.t. without any tumor manifestation. This indicates an increase in the mean survival time of about 900% referred to the untreated animals. In contrast, ZDC and HDC exhibit no recognizable antineoplastic properties under equal experimental conditions.Assuming a similar mechanism of tumor inhibition for both DDP and the antineoplastic active metallocene dichlorides TDC, VDC, and MDC, the comparatively increased non-bonding Cl... Cl distance (“bite”) of ZDC and HDC may be responsible for the cancerostatic inactivity of the latter compounds. More... »

PAGES

43-51

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00412896

DOI

http://dx.doi.org/10.1007/bf00412896

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012360533

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7188941


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