1964-03
AUTHORS ABSTRACTIn short Purkinje fibres net membrane currents during voltage-clamps were measured. For technical reasons current measurement was not possible within the first 10 msec after the onset of clamping. Potassium current was determined as the current flowing in sodium free solution (choline-Tyrode). Sodium current was found by subtraction of the potassium currents from the current flowing in Tyrode solution.Potassium current depends on both the membrane potential and the time. The current voltage relationship shows “anomalous rectification”. In the range from −40 mV to +30 mV the current is larger earlier than later during the clamp. Only on depolarisation beyond +20 mV a small increase of gK was sometimes seen after 200 msec when depolarisation was maintained.Potassium conductance falls on depolarization to 1/3 to 1/2 of resting conductance. In the range from −60 mV to +20 mV conductance is larger early than later during a depolarizing clamp.Sodium current increases on depolarization, the maximum being at about −20 mV. With further depolarization sodium current falls and becomes zero between +30 and +45 mV. Sodium current declines during depolarizing clamps with a time constant in the order of 100 msec. Sodium conductance increases with depolarization and falls during the clamp.Resting sodium conductance was found to be 0.024±0.006 mmho/cm2, resting potassium conductance was determined as 0.45±0.1 mmho/cm2.When after a depolarization membrane potential is clamped back to the resting potential positive current flows which declines within 300 to 500 msec. This current reverses its polarity at about −100 mV. It is assumed that the current is due to an increase of potassium conductance which is brought about by repolarization to at least −40 mV. The results are discussed in relation to the plateau and repolarization of the action potential as well as to the pacemaker potential. More... »
PAGES63-80
http://scigraph.springernature.com/pub.10.1007/bf00412616
DOIhttp://dx.doi.org/10.1007/bf00412616
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/14251606
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