Voltage clamp technique in mammalian cardiac fibres View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1964-03

AUTHORS

K. A. Deck, R. Kern, W. Trautwein

ABSTRACT

A preparation and a technique are described which allow spatially uniform voltage clamp in mammalian cardiac muscle.Sheep Purkinje fibre bundles (diameter 0.07 to 0.2 mm) were ligated twice in a distance of 1 to 2 mm. At the injured ends of this preparation a new membrane of high resistance develops (healing over effect). This can be concluded from the following observations:The resting potentials of about 20% of the preparations recovered to normal values after ligation.In agreement with the cable equations the input resistance of the preparation is increased by a factor of 3.7 when compared with the input resistance of the fibre bundle before ligature.The current voltage relationship of the short preparations was much steeper than those determined in longer fibre bundles. This is to be expected when cable complications are reduced or absent.A negative feedback amplifier is described, which allowed to clamp the membrane potential recorded with an intracellular electrode by current flow through a second intracellular electrode. The circuitry used is able to clamp the membrane potential to constant values when the input resistance varies in the range of 470 to 50 kΩ. When input resistance is less than 50 kΩ clamp potential decreased in spike of increasing feedback current strength.For threshold depolarization constant clamp potentials could be obtained only 10 msec after the onset of the clamp, because of the low input resistance during the spike of the action potential. Spatial uniformity of clamp potentials was controlled. Examples of clamp experiments with the preparation and technique described are shown. The limitations of the method are discussed. More... »

PAGES

50-62

References to SciGraph publications

  • 1964-03. Ionic currents in cardiac excitation in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1963-01. Einfluß des Adrenalins auf den Na- und K-Austausch am Froschvorhof in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1963-01. „Voltageclamp“-Experimente an Herzmuskelfasern in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1877-12. Vergleichende Untersuchungen zur Lehre von der Muskel- und Nervenelektricität in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1960-11. Rectifying Properties of Heart Muscle in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00412615

    DOI

    http://dx.doi.org/10.1007/bf00412615

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1051590079

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14251605


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