Alkylation mutagenesis in Saccharomyces cerevisiae: lack of evidence for an adaptive response View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-05

AUTHORS

Renata Polakowska, Giuditta Perozzi, Louise Prakash

ABSTRACT

We have found no evidence for an adaptive response for either lethality or mutagenesis following treatment of Saccharomyces cerevisiae with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The rad6 and rad52 mutants of S. cerevisiae are highly defective in MNNG and ethyl methanesulfonate induced mutagenesis of both stationary and exponential phase cells. These and other observations indicate that the mechanisms of repair of alkylation damage and mutagenesis differ markedly between S. cerevisiae and Escherichia coli. More... »

PAGES

647-655

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00410912

DOI

http://dx.doi.org/10.1007/bf00410912

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010161117

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3329040


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