Alkyl-lysophospholipids inhibit the growth of hypernephroid carcinomas in vitro View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1981-10

AUTHORS

W. E. Berdel, U. Fink, B. Egger, A. Reichert, P. G. Munder, J. Rastetter

ABSTRACT

Synthetic alkyl-lysophospholipids (ALPs) inhibit the proliferation of human hypernephromas in vitro. Cells of ten different tumors were incubated with 4 ALPs for periods of more than 24h. Eight of ten cell lines showed proliferation rates below 1% of the controls after cultivation. One microgram of ALPs per 10(6) tumor cells was effective, in some experiments a dose response relation was found for even lower concentrations. Equivalent concentrations of cytostatic drugs did not show reproducible higher antitumor effects in vitro. In two of the tested cell lines ALPs did not show any reproducible tumor growth inhibition, whereas at least some of the cytostatic drugs revealed slight cytostatis. More... »

PAGES

325-330

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00410118

DOI

http://dx.doi.org/10.1007/bf00410118

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024194047

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7309782


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