Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-04

AUTHORS

Y. Tanizawa, A. C. Riggs, K. C. Chiu, R. C. Janssen, D. S. H. Bell, R. P. C. Go, J. M. Roseman, R. T. Acton, M. A. Permutt

ABSTRACT

The purpose of these experiments was to test the hypothesis that impaired glucose-stimulated insulin secretion in NIDDM is due to mutations in the islet beta cell/liver glucose transporter (GLUT 2) gene. Using oligonucleotide primers flanking each of the 11 exons, the structural portion of the gene was studied by PCR-SSCP analysis. DNA from African-American females (n = 48), who had gestational diabetes but developed overt NIDDM after delivery, was studied. Each SSCP variant was sequenced directly from genomic DNA. Two amino acid substitutions from the previously reported sequence were found, one in exon 3 and the other in exon 4B. Four additional silent mutations in the coding region, and six intron mutations outside the splice junction consensus sequences, were also identified. The mutation GTC x ATC in exon 4B substituted Val197 to Ile197. This amino acid substitution was found in only one NIDDM patient in a single allele, and was not found in 52 control subjects. This residue exists in the fifth membrane spanning domain, and Val at this position is conserved in mouse and rat GLUT 2, and human GLUT 1 to GLUT 4. The other codon change in exon 3, ACT x ATT, substituted Thr110 to Ile110 in the second membrane spanning domain. To determine the frequency of this non-conservative amino acid substitution, a PCR-LCR assay was developed. This assay was simple and highly specific for detection of this single nucleotide substitution. The allelic frequency of the ATT (Ile110) in NIDDM patients (39.6%, n = 48) and that in controls (47.1%, n = 52) did not differ (p = 0.32, Fisher's exact test).(ABSTRACT TRUNCATED AT 250 WORDS) More... »

PAGES

420-427

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00408481

DOI

http://dx.doi.org/10.1007/bf00408481

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053241955

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8063045


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