The inhibitory effect of PUVA on the immunity of experimental dermatophytosis in guinea pigs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1986-06

AUTHORS

T. Okuwa, T. Horio

ABSTRACT

The effect of topical PUVA on the disease course and immunity of T. mentagrophytes dermatophytosis was investigated in guinea pigs. Animals which had been inoculated on nontreated skin showed mild erythematous lesions with scaling in a few days and then developed the most intense reaction between days 10 and 14. The lesions resolved completely by the third week. On the other hand, animals which had been inoculated on the PUVA-treated sites showed only mild squamous, erythematous lesions until the fourth postinfective week, when the intense reaction began to appear. Complete regression was observed by the fifth week in these animals. Trichophytin tests performed on the 14th day were positive in the guinea pigs of non-treated group, while negative in the PUVA-treated animals. The latter group revealed a positive reaction on the fifth week. PUVA did not show inhibitory effect on the sensitization by intracutaneous injection of trichophytin antigen. The PUVA treatment depleted the ATPase-positive Langerhans' cells. These results indicate that PUVA treatment suppresses the immunity of dermatophytosis and delays the spontaneous resolution of the lesions, and suggest that the Langerhans' cell is involved in the development of cell-mediated immunity in experimental dermatophytosis. More... »

PAGES

320-323

References to SciGraph publications

  • 1976-12. A QUANTITATIVE DERMATOPHYTE INFECTION MODEL IN THE GUINEA-PIG—A PARALLEL TO THE QUANTITATED HUMAN INFECTION MODEL in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1981-10. The Effects of 8-Methoxypsoralen and Long-wave Ultraviolet Light on Langerhans Cell in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1983-02. Immunologic Unresponsiveness Induced by Topical Application of Hapten to PUVA-Treated Skin in Guinea Pigs in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1982-05. The Mechanisms of Inhibitory Effect of 8-Methoxypsoralen and Long-wave Ultraviolet Light on Experimental Contact Sensitization in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1980-12. Trichophyton mentagrophytes Dermatophytosis in Germfree Guinea Pigs in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1973-10. TRICHOPHYTIN CONTACT SENSITIVITY IN GUINEA PIGS WITH EXPERIMENTAL DERMATOPHYTOSIS INDUCED BY A NEW INOCULATION METHOD in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1983-03. Modulation of Expression of Epidermal Langerhans Cell Properties Following in Situ Exposure to Glucocorticosteroids in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1983-07. The Thymus Dependency of Acquired Resistance to Trichophyton mentagrophytes Dermatophytosis in Rats in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1984-06. Biology of Langerhans Cells: Analysis by Experiments to Deplete Langerhans Cells from Human Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1963-06. The Trichophyton Mentagrophytes and Microsporum Canis Infection of the Guinea-Pig in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00407746

    DOI

    http://dx.doi.org/10.1007/bf00407746

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010490687

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3740941


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