Zur Frage der Permeabilität von N, N-Bis(2-chloräthyl)-phosphorsäurediamid in Tumorzellen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1979-01

AUTHORS

U. Lenssen, H. J. Hohorst

ABSTRACT

The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclophosphamide and 4-hydroperoxycyclophosphamide (1 mM) were shown to permeate into the cells very easily reaching saturation values. Thus lack of permeation into tumor cells of N,N-bis(2-chloroethyl)-diamidophosphoric-acid seems to be the reason for the poor cytotoxic activity of this metabolite of cyclophosphamide. More... »

PAGES

161-164

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00406573

DOI

http://dx.doi.org/10.1007/bf00406573

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042527304

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/438280


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