Ontology type: schema:ScholarlyArticle
1988-06
AUTHORSHans-Jürgen Hohorst, Ludmilla Bielicki, Klaus Müller, Georg Voelcker
ABSTRACTThiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters were designed to act as highly specific suicide inactivators of DNA polymerase alpha holoenzymes. Acute and subacute toxicity of these drugs in mice was very small. By daily i.p. injection, on day 0-4 mice were cured of P 388 lymphatic leukaemia with no depression of blood leucocytes. The findings suggest that suicide inactivators of DNA polymerase alpha holoenzyme may be promising drugs for low toxicity cancer chemotherapy. More... »
PAGES309-311
http://scigraph.springernature.com/pub.10.1007/bf00405840
DOIhttp://dx.doi.org/10.1007/bf00405840
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1049181361
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/3384844
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "DNA Polymerase II",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kinetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia P388",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukemia, Experimental",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nitrogen Mustard Compounds",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thiazines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thiazoles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thiazolidines",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Goethe University Frankfurt",
"id": "https://www.grid.ac/institutes/grid.7839.5",
"name": [
"Gustav-Embden-Zentrum of Biological Chemistry, University of Frankfurt/Main, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany"
],
"type": "Organization"
},
"familyName": "Hohorst",
"givenName": "Hans-J\u00fcrgen",
"id": "sg:person.053543626.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053543626.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Goethe University Frankfurt",
"id": "https://www.grid.ac/institutes/grid.7839.5",
"name": [
"Gustav-Embden-Zentrum of Biological Chemistry, University of Frankfurt/Main, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany"
],
"type": "Organization"
},
"familyName": "Bielicki",
"givenName": "Ludmilla",
"id": "sg:person.01365215203.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365215203.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Goethe University Frankfurt",
"id": "https://www.grid.ac/institutes/grid.7839.5",
"name": [
"Gustav-Embden-Zentrum of Biological Chemistry, University of Frankfurt/Main, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany"
],
"type": "Organization"
},
"familyName": "M\u00fcller",
"givenName": "Klaus",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Goethe University Frankfurt",
"id": "https://www.grid.ac/institutes/grid.7839.5",
"name": [
"Gustav-Embden-Zentrum of Biological Chemistry, University of Frankfurt/Main, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Federal Republic of Germany"
],
"type": "Organization"
},
"familyName": "Voelcker",
"givenName": "Georg",
"id": "sg:person.072236252.36",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.072236252.36"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf00284124",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013128331",
"https://doi.org/10.1007/bf00284124"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01032606",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020291418",
"https://doi.org/10.1007/bf01032606"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.81.13.3993",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026699526"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0065-2571(86)90010-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031024932"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0065-2571(86)90010-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031024932"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00391828",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052681528",
"https://doi.org/10.1007/bf00391828"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00391828",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052681528",
"https://doi.org/10.1007/bf00391828"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi00658a018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055184304"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080283389",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080629042",
"type": "CreativeWork"
}
],
"datePublished": "1988-06",
"datePublishedReg": "1988-06-01",
"description": "Thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters were designed to act as highly specific suicide inactivators of DNA polymerase alpha holoenzymes. Acute and subacute toxicity of these drugs in mice was very small. By daily i.p. injection, on day 0-4 mice were cured of P 388 lymphatic leukaemia with no depression of blood leucocytes. The findings suggest that suicide inactivators of DNA polymerase alpha holoenzyme may be promising drugs for low toxicity cancer chemotherapy.",
"genre": "research_article",
"id": "sg:pub.10.1007/bf00405840",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1313647",
"issn": [
"0171-5216",
"1432-1335"
],
"name": "Journal of Cancer Research and Clinical Oncology",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "114"
}
],
"name": "Low toxicity cancer chemotherapy by suicide inactivation of DNA polymerase \u03b1 holoenzyme: first results with new thiazolidinyl-and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters",
"pagination": "309-311",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"ea4a357a918ec930710716a9b25661af6b18309d6f7edd81f59417ab4631a57a"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"3384844"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"7902060"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/bf00405840"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1049181361"
]
}
],
"sameAs": [
"https://doi.org/10.1007/bf00405840",
"https://app.dimensions.ai/details/publication/pub.1049181361"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:58",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130820_00000004.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/BF00405840"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00405840'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00405840'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00405840'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00405840'
This table displays all metadata directly associated to this object as RDF triples.
158 TRIPLES
21 PREDICATES
48 URIs
32 LITERALS
20 BLANK NODES