Low toxicity cancer chemotherapy by suicide inactivation of DNA polymerase α holoenzyme: first results with new thiazolidinyl-and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1988-06

AUTHORS

Hans-Jürgen Hohorst, Ludmilla Bielicki, Klaus Müller, Georg Voelcker

ABSTRACT

Thiazolidinyl- and perhydrothiazinyl-ethyl-N-mustard-phosphamide esters were designed to act as highly specific suicide inactivators of DNA polymerase alpha holoenzymes. Acute and subacute toxicity of these drugs in mice was very small. By daily i.p. injection, on day 0-4 mice were cured of P 388 lymphatic leukaemia with no depression of blood leucocytes. The findings suggest that suicide inactivators of DNA polymerase alpha holoenzyme may be promising drugs for low toxicity cancer chemotherapy. More... »

PAGES

309-311

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00405840

DOI

http://dx.doi.org/10.1007/bf00405840

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049181361

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/3384844


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