Self-administration of psychoactive substances by the monkey View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1969-01

AUTHORS

Gerald Deneau, Tomoji Yanagita, M. H. Seevers

ABSTRACT

A method has been developed which permits monkeys to self-administer drug solutions, at will, through indwelling intravenous catheters. Psychological dependence on the effects of a drug occurs when a naive monkey voluntarily initiates and maintains self-administration of the drug. If, in addition to psychological dependence, the drug also produces psychotoxicity, either directly or upon abrupt withdrawal, it has a potential abuse liability. In the present study monkeys developed psychological dependence on morphine, codeine, cocaine, d-amphetamine, pentobarbital, ethanol, and caffeine. All of these drugs except caffeine produced psychotoxicity. Monkeys did not develop psychological dependence on nalorphine, morphine-nalorphine mixtures, chlorpromazine, mescaline or physiological saline. More... »

PAGES

30-48

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00405254

DOI

http://dx.doi.org/10.1007/bf00405254

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028425305

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4982648


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