Lindane binding to sections of human skin: Skin capacity and isotherm determinations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1984-08

AUTHORS

E. Menczel, D. Bucks, H. Maibach, R. Wester

ABSTRACT

Human autopsy skin was sliced into three sections; an outer epidermis-rich layer, a middle dermis layer, and an inner dermis and subcutaneous fat layer. Each slice was bathed in lindane solutions over a 50-fold concentration range for 48 h at 37 degrees C. Lindane uptake by the skin was extensive (less than 90%) for all concentrations and all skin slices. Equilibrium dialysis with lindane at 37 degrees C for 24 h showed binding affinities by the skin sections to exceed 98%. The binding constants of the outer skin section (epidermis-rich) were higher than those of the middle and inner sections. The binding attraction for lindane by United States Pharmacopeia (USP) human plasma protein fraction (mean 90.5% bound) resulted in its competitive extraction from the skin slices in a three-compartment dialytic procedure. Since the least binding constants were in the middle and inner layers, and since lindane has a preference for plasma over skin, the two (inner skin and plasma) may combine to create the sink conditions necessary for lindane percutaneous absorption into the body. This plus the high epidermis capacity for lindane explains why in some instances (such as occlusion) high levels of lindane can be percutaneously absorbed. More... »

PAGES

326-329

References to SciGraph publications

  • 1983-11. Malathion binding to sections of human skin: Skin capacity and isotherm determinations in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1980-08. A rapid method for measuring drug enrichment in epidermis in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00404626

    DOI

    http://dx.doi.org/10.1007/bf00404626

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045750072

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/6207781


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