IDDM susceptibility associated with polymorphisms in the insulin gene region A study of blacks, Caucasians and orientals View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-08

AUTHORS

D. E. Undlien, K. Hamaguchi, A. Kimura, E. Tuomilehto-Wolf, A. B. M. Swai, D. G. McLarty, J. Tuomilehto, E. Thorsby, K. S. RØnningen

ABSTRACT

Previous studies have suggested an association between polymorphisms in the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Most of the studies so far have been performed in Caucasoid populations. We have investigated 418 random IDDM patients and 422 healthy control subjects from three different ethnic groups; Tanzanian blacks, Norwegian Caucasians and Japanese orientals. Our data suggest that polymorphisms in the insulin gene region confer susceptibility to IDDM in Caucasians, and that a similar tendency though not statistically significant is observed among Tanzanian blacks, while no significant contribution is seen among Japanese orientals. We further demonstrate that the disease-associated genotype INS +/+ confers susceptibility independently of HLA class II alleles associated with IDDM. Compared to the contribution of particular HLA-DQ alleles in IDDM susceptibility, the additional risk conferred by the insulin gene region polymorphism is, however, small. Genotyping of the insulin gene region will therefore most probably not be a useful tool in the prediction of IDDM. More... »

PAGES

745-749

References to SciGraph publications

  • 1992-11. Insulin gene region–encoded susceptibility to type 1 diabetes is not restricted to HLA–DR4–positive individuals in NATURE GENETICS
  • 1985-04. Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11 in DIABETOLOGIA
  • 1991-09. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1 in NATURE
  • 1991-11. Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility in NATURE
  • 1993-07. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR in NATURE GENETICS
  • 1991-06. Genetic analysis of autoimmune type 1 diabetes mellitus in mice in NATURE
  • 1989-10. Aspartic acid at position 57 of DQβ chain does not protect against Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects in DIABETOLOGIA
  • 1992-11. Concordance for Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland in DIABETOLOGIA
  • 1990-07. Identification of susceptibility loci for Type 1 (insulin-dependent) diabetes by trans-racial gene mapping in DIABETOLOGIA
  • 1981-02. Diabetes in identical twins in DIABETOLOGIA
  • 1993-08. Polygenic control of autoimmune diabetes in nonobese diabetic mice in NATURE GENETICS
  • 1985-12. Restriction fragment length polymorphism of the insulin gene region in Japanese diabetic and non-diabetic subjects in DIABETOLOGIA
  • 1985. HLA and Disease Associations in NONE
  • 1986-06. High frequency of class 3 allele in the human insulin gene in Japanese Type 2 (non-insulin-dependent) diabetic patients with a family history of diabetes in DIABETOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/bf00404330

    DOI

    http://dx.doi.org/10.1007/bf00404330

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001786266

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7988775


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