Thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in NIDDM patients treated by diet, sulphonylurea or insulin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-06

AUTHORS

T. Ishizuka, O. Taniguchi, M. Yamamoto, K. Kajita, T. Nagashima, N. Takeda, H. Inouye, K. Yasuda, K. Miura

ABSTRACT

We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thrombin-induced platelet aggregation was measured with an aggregometer. Low-dose thrombin (0.25 U/ml)-stimulated platelet aggregation in diabetic patients was significantly increased compared with the control subjects. Platelet aggregation in the sulphonylurea and insulin groups was significantly lower than in the diet group. On the other hand, in platelets incubated with [32P]orthophosphate, thrombin-induced incorporation of 32P radioactivity into phosphatidic acid (PA) was significantly lower in the sulphonylurea and insulin groups than in the diet group. Thrombin-induced incorporation of [32P] radioactivity into phosphatidylinositol (PIP) for 10 s was significantly higher in the sulphonylurea group than in the diet group. There were no differences in thrombin-induced 47 kDa protein phosphorylation between platelets from the diet, sulphonylurea, or insulin groups. These results suggest that sulphonylureas and insulin induce suppression of thrombin-induced activation of phospholipase C, which mediates hydrolysis of PIP and PIP2 and production of PA, which leads to inhibition of platelet aggregation. More... »

PAGES

632-638

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00403384

DOI

http://dx.doi.org/10.1007/bf00403384

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008205291

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7926350


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Platelets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Aggregation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sulfonylurea Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thrombin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Type C Phospholipases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishizuka", 
        "givenName": "T.", 
        "id": "sg:person.0617540772.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617540772.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taniguchi", 
        "givenName": "O.", 
        "id": "sg:person.0704150342.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704150342.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "M.", 
        "id": "sg:person.011276272401.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011276272401.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kajita", 
        "givenName": "K.", 
        "id": "sg:person.0730126272.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730126272.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagashima", 
        "givenName": "T.", 
        "id": "sg:person.01223755063.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223755063.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeda", 
        "givenName": "N.", 
        "id": "sg:person.0770314251.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770314251.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inouye", 
        "givenName": "H.", 
        "id": "sg:person.0722527145.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722527145.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yasuda", 
        "givenName": "K.", 
        "id": "sg:person.011270372042.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011270372042.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miura", 
        "givenName": "K.", 
        "id": "sg:person.012460100402.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012460100402.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1042/bj2280451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000734076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2280451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000734076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.18.6785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000826992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/o59-099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001206449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)90482-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008423600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)90482-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008423600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10641968709160027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013691625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00281120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019306382", 
          "https://doi.org/10.1007/bf00281120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00281120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019306382", 
          "https://doi.org/10.1007/bf00281120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00281120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019306382", 
          "https://doi.org/10.1007/bf00281120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(83)90256-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020348771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci109854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022011095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/333470a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022440822", 
          "https://doi.org/10.1038/333470a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(82)90116-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025685809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(82)90116-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025685809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00422396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030507016", 
          "https://doi.org/10.1007/bf00422396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00422396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030507016", 
          "https://doi.org/10.1007/bf00422396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(83)91267-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031183010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1507/endocrj1954.38.81", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037283635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(81)90094-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038103013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(81)90094-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038103013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2420011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044078099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2420011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044078099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci109339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046668206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2220157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051334062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj2220157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051334062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/194927b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052048522", 
          "https://doi.org/10.1038/194927b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)90483-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052323355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)90483-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052323355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3107122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062590852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/y59-099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062895331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.27.3.342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070733256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.38.9.1097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070735947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diab.39.12.1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070736026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.39.12.1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070741763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-82-6-733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073732985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074330381", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079564052", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079584204", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080041888", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00276813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081595249", 
          "https://doi.org/10.1007/bf00276813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00276813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081595249", 
          "https://doi.org/10.1007/bf00276813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081663871", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081727662", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081739380", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00281545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082295516", 
          "https://doi.org/10.1007/bf00281545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00281545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082295516", 
          "https://doi.org/10.1007/bf00281545"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-06", 
    "datePublishedReg": "1994-06-01", 
    "description": "We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thrombin-induced platelet aggregation was measured with an aggregometer. Low-dose thrombin (0.25 U/ml)-stimulated platelet aggregation in diabetic patients was significantly increased compared with the control subjects. Platelet aggregation in the sulphonylurea and insulin groups was significantly lower than in the diet group. On the other hand, in platelets incubated with [32P]orthophosphate, thrombin-induced incorporation of 32P radioactivity into phosphatidic acid (PA) was significantly lower in the sulphonylurea and insulin groups than in the diet group. Thrombin-induced incorporation of [32P] radioactivity into phosphatidylinositol (PIP) for 10 s was significantly higher in the sulphonylurea group than in the diet group. There were no differences in thrombin-induced 47 kDa protein phosphorylation between platelets from the diet, sulphonylurea, or insulin groups. These results suggest that sulphonylureas and insulin induce suppression of thrombin-induced activation of phospholipase C, which mediates hydrolysis of PIP and PIP2 and production of PA, which leads to inhibition of platelet aggregation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/bf00403384", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "Thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in NIDDM patients treated by diet, sulphonylurea or insulin", 
    "pagination": "632-638", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "27176a13610c8785c05aefa32b140ee21add42c4f33e793dc3d280b97fe66042"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7926350"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0006777"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00403384"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008205291"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00403384", 
      "https://app.dimensions.ai/details/publication/pub.1008205291"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130814_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2FBF00403384"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00403384'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00403384'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00403384'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00403384'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      79 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00403384 schema:about N01e84cb71d8b4e7ba2e926289bcffb15
2 N036f4d69da5e4959b450a7de9671a951
3 N1347649629ca4c7dba20099f0d5b901f
4 N1394ff8028894825bc099bbed2244a05
5 N280babc554044a9f99818b113327d4f1
6 N353829967b4e48b1b17b401442f47f47
7 N36010edd99074472a4d4271c66224d41
8 N3a76cdb9737845b285f6df992d97c402
9 N43a42b35dc45474494400b460310a043
10 Na55418d131c34743900065552e27573f
11 Naf3fdc5d30704edcb8835921be23ce33
12 Nbd0ea69fd6f44d28b0f72368935f5f26
13 Nc06d65347c754ec99fc154931c11e032
14 Nc3081b00ba094c8886c4afeee6dc547b
15 Nf8d904976a01489e85989a7de1311c76
16 anzsrc-for:11
17 anzsrc-for:1103
18 schema:author N3ca8675ecff2412d8986d185a91dfa3e
19 schema:citation sg:pub.10.1007/bf00276813
20 sg:pub.10.1007/bf00281120
21 sg:pub.10.1007/bf00281545
22 sg:pub.10.1007/bf00422396
23 sg:pub.10.1038/194927b0
24 sg:pub.10.1038/333470a0
25 https://app.dimensions.ai/details/publication/pub.1074330381
26 https://app.dimensions.ai/details/publication/pub.1079564052
27 https://app.dimensions.ai/details/publication/pub.1079584204
28 https://app.dimensions.ai/details/publication/pub.1080041888
29 https://app.dimensions.ai/details/publication/pub.1081663871
30 https://app.dimensions.ai/details/publication/pub.1081727662
31 https://app.dimensions.ai/details/publication/pub.1081739380
32 https://doi.org/10.1016/0002-9343(83)90256-5
33 https://doi.org/10.1016/0005-2760(81)90094-1
34 https://doi.org/10.1016/0005-2760(82)90116-3
35 https://doi.org/10.1016/0006-291x(83)91267-6
36 https://doi.org/10.1016/s0140-6736(78)90482-8
37 https://doi.org/10.1016/s0140-6736(78)90483-x
38 https://doi.org/10.1042/bj2220157
39 https://doi.org/10.1042/bj2280451
40 https://doi.org/10.1042/bj2420011
41 https://doi.org/10.1073/pnas.83.18.6785
42 https://doi.org/10.1126/science.3107122
43 https://doi.org/10.1139/o59-099
44 https://doi.org/10.1139/y59-099
45 https://doi.org/10.1172/jci109339
46 https://doi.org/10.1172/jci109854
47 https://doi.org/10.1507/endocrj1954.38.81
48 https://doi.org/10.2337/diab.27.3.342
49 https://doi.org/10.2337/diab.38.9.1097
50 https://doi.org/10.2337/diab.39.12.1561
51 https://doi.org/10.2337/diabetes.39.12.1561
52 https://doi.org/10.3109/10641968709160027
53 https://doi.org/10.7326/0003-4819-82-6-733
54 schema:datePublished 1994-06
55 schema:datePublishedReg 1994-06-01
56 schema:description We studied thrombin-induced metabolism of phosphoinositide, protein phosphorylation and platelet aggregation in platelets from 32 NIDDM patients and 12 control subjects. To clarify the effect of diet, sulphonylureas, or insulin treatment, the subjects were divided into three groups based on the type of treatment. Thrombin-induced platelet aggregation was measured with an aggregometer. Low-dose thrombin (0.25 U/ml)-stimulated platelet aggregation in diabetic patients was significantly increased compared with the control subjects. Platelet aggregation in the sulphonylurea and insulin groups was significantly lower than in the diet group. On the other hand, in platelets incubated with [32P]orthophosphate, thrombin-induced incorporation of 32P radioactivity into phosphatidic acid (PA) was significantly lower in the sulphonylurea and insulin groups than in the diet group. Thrombin-induced incorporation of [32P] radioactivity into phosphatidylinositol (PIP) for 10 s was significantly higher in the sulphonylurea group than in the diet group. There were no differences in thrombin-induced 47 kDa protein phosphorylation between platelets from the diet, sulphonylurea, or insulin groups. These results suggest that sulphonylureas and insulin induce suppression of thrombin-induced activation of phospholipase C, which mediates hydrolysis of PIP and PIP2 and production of PA, which leads to inhibition of platelet aggregation.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N0097df67ddbc433cb31a0e1e85c0fd6f
61 Nf0a8a54455994ebe88e2ebaa75ed2013
62 sg:journal.1001482
63 schema:name Thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in NIDDM patients treated by diet, sulphonylurea or insulin
64 schema:pagination 632-638
65 schema:productId N6241df17a1bf40958f9105492ef0109a
66 Nada867fdb75c4f39a8c86a200d96b07d
67 Nc50f8d3133ef4dc5b537adc9fe362624
68 Ne1caab37bc05425797fdfab365b2bf5b
69 Ne855f6ea806e474f8618fe16ab4f97a2
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008205291
71 https://doi.org/10.1007/bf00403384
72 schema:sdDatePublished 2019-04-11T13:55
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Na1ec0cb46ca34ca6b3abb90d065c8e22
75 schema:url https://link.springer.com/10.1007%2FBF00403384
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0097df67ddbc433cb31a0e1e85c0fd6f schema:issueNumber 6
80 rdf:type schema:PublicationIssue
81 N01e84cb71d8b4e7ba2e926289bcffb15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Diabetes Mellitus, Type 2
83 rdf:type schema:DefinedTerm
84 N036f4d69da5e4959b450a7de9671a951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Thrombin
86 rdf:type schema:DefinedTerm
87 N1347649629ca4c7dba20099f0d5b901f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Sulfonylurea Compounds
89 rdf:type schema:DefinedTerm
90 N1394ff8028894825bc099bbed2244a05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Type C Phospholipases
92 rdf:type schema:DefinedTerm
93 N2739fc5493b3433e849849c56826de96 rdf:first sg:person.012460100402.06
94 rdf:rest rdf:nil
95 N280babc554044a9f99818b113327d4f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Adult
97 rdf:type schema:DefinedTerm
98 N353829967b4e48b1b17b401442f47f47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Middle Aged
100 rdf:type schema:DefinedTerm
101 N36010edd99074472a4d4271c66224d41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Phosphorylation
103 rdf:type schema:DefinedTerm
104 N3a76cdb9737845b285f6df992d97c402 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Insulin
106 rdf:type schema:DefinedTerm
107 N3ca8675ecff2412d8986d185a91dfa3e rdf:first sg:person.0617540772.05
108 rdf:rest Nef60e2beda5c43799c27a50896b4f724
109 N43a42b35dc45474494400b460310a043 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Blood Platelets
111 rdf:type schema:DefinedTerm
112 N560ded4a9b8a4e6399581c1bc01bbf7a rdf:first sg:person.011270372042.82
113 rdf:rest N2739fc5493b3433e849849c56826de96
114 N5a2d12089b854c01a982d3551e768c50 rdf:first sg:person.0730126272.48
115 rdf:rest Nbe5bc2467642448695feb0f9effcd8c2
116 N6241df17a1bf40958f9105492ef0109a schema:name pubmed_id
117 schema:value 7926350
118 rdf:type schema:PropertyValue
119 N68637cdbf2ea4234b625cecfaeed7b7f rdf:first sg:person.011276272401.45
120 rdf:rest N5a2d12089b854c01a982d3551e768c50
121 Na1ec0cb46ca34ca6b3abb90d065c8e22 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 Na55418d131c34743900065552e27573f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Platelet Aggregation
125 rdf:type schema:DefinedTerm
126 Nada867fdb75c4f39a8c86a200d96b07d schema:name dimensions_id
127 schema:value pub.1008205291
128 rdf:type schema:PropertyValue
129 Naf3fdc5d30704edcb8835921be23ce33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Phosphatidylinositols
131 rdf:type schema:DefinedTerm
132 Nbd0ea69fd6f44d28b0f72368935f5f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Aged
134 rdf:type schema:DefinedTerm
135 Nbe5bc2467642448695feb0f9effcd8c2 rdf:first sg:person.01223755063.00
136 rdf:rest Nf473e18289c64092ad53ef0fa31e9c06
137 Nc04267f5bdcc46bb8f7052490e51b001 rdf:first sg:person.0722527145.70
138 rdf:rest N560ded4a9b8a4e6399581c1bc01bbf7a
139 Nc06d65347c754ec99fc154931c11e032 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Female
141 rdf:type schema:DefinedTerm
142 Nc3081b00ba094c8886c4afeee6dc547b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 Nc50f8d3133ef4dc5b537adc9fe362624 schema:name readcube_id
146 schema:value 27176a13610c8785c05aefa32b140ee21add42c4f33e793dc3d280b97fe66042
147 rdf:type schema:PropertyValue
148 Ne1caab37bc05425797fdfab365b2bf5b schema:name nlm_unique_id
149 schema:value 0006777
150 rdf:type schema:PropertyValue
151 Ne855f6ea806e474f8618fe16ab4f97a2 schema:name doi
152 schema:value 10.1007/bf00403384
153 rdf:type schema:PropertyValue
154 Nef60e2beda5c43799c27a50896b4f724 rdf:first sg:person.0704150342.38
155 rdf:rest N68637cdbf2ea4234b625cecfaeed7b7f
156 Nf0a8a54455994ebe88e2ebaa75ed2013 schema:volumeNumber 37
157 rdf:type schema:PublicationVolume
158 Nf473e18289c64092ad53ef0fa31e9c06 rdf:first sg:person.0770314251.65
159 rdf:rest Nc04267f5bdcc46bb8f7052490e51b001
160 Nf8d904976a01489e85989a7de1311c76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Humans
162 rdf:type schema:DefinedTerm
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
167 schema:name Clinical Sciences
168 rdf:type schema:DefinedTerm
169 sg:journal.1001482 schema:issn 0012-186X
170 1432-0428
171 schema:name Diabetologia
172 rdf:type schema:Periodical
173 sg:person.011270372042.82 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
174 schema:familyName Yasuda
175 schema:givenName K.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011270372042.82
177 rdf:type schema:Person
178 sg:person.011276272401.45 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
179 schema:familyName Yamamoto
180 schema:givenName M.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011276272401.45
182 rdf:type schema:Person
183 sg:person.01223755063.00 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
184 schema:familyName Nagashima
185 schema:givenName T.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223755063.00
187 rdf:type schema:Person
188 sg:person.012460100402.06 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
189 schema:familyName Miura
190 schema:givenName K.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012460100402.06
192 rdf:type schema:Person
193 sg:person.0617540772.05 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
194 schema:familyName Ishizuka
195 schema:givenName T.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617540772.05
197 rdf:type schema:Person
198 sg:person.0704150342.38 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
199 schema:familyName Taniguchi
200 schema:givenName O.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704150342.38
202 rdf:type schema:Person
203 sg:person.0722527145.70 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
204 schema:familyName Inouye
205 schema:givenName H.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722527145.70
207 rdf:type schema:Person
208 sg:person.0730126272.48 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
209 schema:familyName Kajita
210 schema:givenName K.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730126272.48
212 rdf:type schema:Person
213 sg:person.0770314251.65 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
214 schema:familyName Takeda
215 schema:givenName N.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770314251.65
217 rdf:type schema:Person
218 sg:pub.10.1007/bf00276813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081595249
219 https://doi.org/10.1007/bf00276813
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/bf00281120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019306382
222 https://doi.org/10.1007/bf00281120
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/bf00281545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082295516
225 https://doi.org/10.1007/bf00281545
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/bf00422396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030507016
228 https://doi.org/10.1007/bf00422396
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/194927b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052048522
231 https://doi.org/10.1038/194927b0
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/333470a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022440822
234 https://doi.org/10.1038/333470a0
235 rdf:type schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1074330381 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1079564052 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1079584204 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1080041888 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1081663871 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1081727662 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1081739380 schema:CreativeWork
243 https://doi.org/10.1016/0002-9343(83)90256-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020348771
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0005-2760(81)90094-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038103013
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0005-2760(82)90116-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025685809
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0006-291x(83)91267-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031183010
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/s0140-6736(78)90482-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008423600
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0140-6736(78)90483-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052323355
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1042/bj2220157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051334062
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1042/bj2280451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000734076
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1042/bj2420011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044078099
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1073/pnas.83.18.6785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000826992
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1126/science.3107122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062590852
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1139/o59-099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001206449
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1139/y59-099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062895331
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1172/jci109339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046668206
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1172/jci109854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022011095
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1507/endocrj1954.38.81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037283635
274 rdf:type schema:CreativeWork
275 https://doi.org/10.2337/diab.27.3.342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070733256
276 rdf:type schema:CreativeWork
277 https://doi.org/10.2337/diab.38.9.1097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070735947
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2337/diab.39.12.1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070736026
280 rdf:type schema:CreativeWork
281 https://doi.org/10.2337/diabetes.39.12.1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070741763
282 rdf:type schema:CreativeWork
283 https://doi.org/10.3109/10641968709160027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013691625
284 rdf:type schema:CreativeWork
285 https://doi.org/10.7326/0003-4819-82-6-733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073732985
286 rdf:type schema:CreativeWork
287 https://www.grid.ac/institutes/grid.256342.4 schema:alternateName Gifu University
288 schema:name The Third Department of Internal Medicine, Gifu University School of Medicine, Tsukasamachi 40, 500, Gifu, Japan
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...