Increased agglutinability of bladder epithelial cells by concanavalin A in rats fed several biphenyl derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1983-12

AUTHORS

Y. Honma, T. Kakizoe, H. Komatsu, T. Niijima, T. Sugimura

ABSTRACT

Biphenyl and its derivatives, 2-aminobiphenyl, 2-nitrobiphenyl, 4-aminobiphenyl, 4-nitrobiphenyl, p-phenylphenol, o-phenylphenol (OPP), and o-phenylphenol sodium salt tetrahydrate (OPP-Na) were examined for their bladder carcinogenicity in rats by a short-term assay for agglutinability of bladder epithelial cells with concanavalin A. Increased agglutinability was observed after 1-week treatment with 2.0% and 1.0% OPP, 2.0% and 1.0% OPP-Na, 0.5 and 0.1% 4-aminobiphenyl, and 0.5% 4-nitrobiphenyl in the diet, suggesting carcinogenicity of these compounds in the bladder. Such an increase in agglutinability was not observed in rats fed diets containing biphenyl, 2-aminobiphenyl, 2-nitrobiphenyl or p-phenylphenol at 2.0%. With OPP-Na, an in vivo carcinogenesis experiment was performed. Bladder carcinomas developed in 14 of 36 male Fisher rats fed a 2% OPP-Na diet for 50 weeks. More... »

PAGES

176-178

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00402604

DOI

http://dx.doi.org/10.1007/bf00402604

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001430802

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6654951


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