Hyperproinsulinaemia in patients with myotonic dystrophy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-12

AUTHORS

A. J. Krentz, P. M. Clark, L. Cox, A. C. Williams, M. Nattrass

ABSTRACT

Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after an overnight fast in ten patients with myotonic dystrophy using two-site monoclonal antibody-based immunoradiometric assays. Results were compared with ten healthy control subjects matched for age, gender, and body mass index. Oral glucose tolerance (75 g), as defined by World Health Organization criteria, was normal in all subjects. Fasting plasma immunoreactive insulin concentration, as determined using a conventional radioimmunoassay, was almost three times higher (p<0.005) in the myotonic dystrophy patients than the healthy control subjects. By contrast, fasting concentrations (mean±SEM) of C-peptide (0.75±0.09 vs 0.52±0.03 nmol/l, p=0.07) and immunoradiometrically-determined insulin (60±12 vs 38±4 pmol/l, p=0.09) were not significantly different between the groups. Fasting concentrations of proinsulin (10.3±2.9 vs 1.6±0.3 pmol/l, p<0.01), and 32–33 split proinsulin (7.8±2.5 vs 2.9±0.4 pmol/l, p<0.05) were significantly elevated in the patients with myotonic dystrophy. Accordingly, the mean fasting proinsulin∶insulin ratio, expressed as a percentage, was significantly increased in the myotonic patients (20±5 vs 4±1%, p<0.01). The overall C-peptide response to the oral glucose challenge was significantly greater in the myotonic patients compared with the healthy control subjects (p<0.001). These results provide corroborative evidence of increased beta-cell secretion in myotonic dystrophy. In addition, myotonic dystrophy is characterised by elevated plasma concentrations of proinsulin-like molecules which may cross-react in insulin radioimmunoassays. More... »

PAGES

1170-1172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/bf00401372

DOI

http://dx.doi.org/10.1007/bf00401372

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048912001

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1478370


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Peptide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fasting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Tolerance Test", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myotonic Dystrophy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proinsulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radioimmunoassay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reference Values", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Diabetic Clinic, The General Hospital, Birmingham", 
          "id": "http://www.grid.ac/institutes/grid.415359.f", 
          "name": [
            "Diabetic Clinic, The General Hospital, Birmingham"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krentz", 
        "givenName": "A. J.", 
        "id": "sg:person.0676605226.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676605226.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neurology, Queen Elizabeth Hospital, Birmingham", 
          "id": "http://www.grid.ac/institutes/grid.415490.d", 
          "name": [
            "Department of Clinical Neurology, Queen Elizabeth Hospital, Birmingham"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clark", 
        "givenName": "P. M.", 
        "id": "sg:person.013306426342.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013306426342.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Neurology, Queen Elizabeth Hospital, Birmingham", 
          "id": "http://www.grid.ac/institutes/grid.415490.d", 
          "name": [
            "Department of Clinical Neurology, Queen Elizabeth Hospital, Birmingham"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cox", 
        "givenName": "L.", 
        "id": "sg:person.01102473156.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102473156.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK", 
          "id": "http://www.grid.ac/institutes/grid.120073.7", 
          "name": [
            "Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Williams", 
        "givenName": "A. C.", 
        "id": "sg:person.012652700122.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012652700122.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diabetic Clinic, The General Hospital, Birmingham", 
          "id": "http://www.grid.ac/institutes/grid.415359.f", 
          "name": [
            "Diabetic Clinic, The General Hospital, Birmingham"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nattrass", 
        "givenName": "M.", 
        "id": "sg:person.01013175117.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013175117.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00281991", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037834209", 
          "https://doi.org/10.1007/bf00281991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00273856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080015905", 
          "https://doi.org/10.1007/bf00273856"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1992-12", 
    "datePublishedReg": "1992-12-01", 
    "description": "Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after an overnight fast in ten patients with myotonic dystrophy using two-site monoclonal antibody-based immunoradiometric assays. Results were compared with ten healthy control subjects matched for age, gender, and body mass index. Oral glucose tolerance (75 g), as defined by World Health Organization criteria, was normal in all subjects. Fasting plasma immunoreactive insulin concentration, as determined using a conventional radioimmunoassay, was almost three times higher (p<0.005) in the myotonic dystrophy patients than the healthy control subjects. By contrast, fasting concentrations (mean\u00b1SEM) of C-peptide (0.75\u00b10.09 vs 0.52\u00b10.03 nmol/l, p=0.07) and immunoradiometrically-determined insulin (60\u00b112 vs 38\u00b14 pmol/l, p=0.09) were not significantly different between the groups. Fasting concentrations of proinsulin (10.3\u00b12.9 vs 1.6\u00b10.3 pmol/l, p<0.01), and 32\u201333 split proinsulin (7.8\u00b12.5 vs 2.9\u00b10.4 pmol/l, p<0.05) were significantly elevated in the patients with myotonic dystrophy. Accordingly, the mean fasting proinsulin\u2236insulin ratio, expressed as a percentage, was significantly increased in the myotonic patients (20\u00b15 vs 4\u00b11%, p<0.01). The overall C-peptide response to the oral glucose challenge was significantly greater in the myotonic patients compared with the healthy control subjects (p<0.001). These results provide corroborative evidence of increased beta-cell secretion in myotonic dystrophy. In addition, myotonic dystrophy is characterised by elevated plasma concentrations of proinsulin-like molecules which may cross-react in insulin radioimmunoassays.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/bf00401372", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1001482", 
        "issn": [
          "0012-186X", 
          "1432-0428"
        ], 
        "name": "Diabetologia", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "healthy control subjects", 
      "control subjects", 
      "myotonic dystrophy", 
      "two-site monoclonal antibody-based immunoradiometric assays", 
      "myotonic patients", 
      "plasma immunoreactive insulin concentration", 
      "beta-cell secretion", 
      "World Health Organization criteria", 
      "oral glucose tolerance", 
      "oral glucose challenge", 
      "body mass index", 
      "beta cell response", 
      "immunoreactive insulin concentrations", 
      "concentrations of proinsulin", 
      "elevated plasma concentrations", 
      "concentrations of insulin", 
      "proinsulin-like molecules", 
      "myotonic dystrophy patients", 
      "glucose tolerance", 
      "overnight fast", 
      "mass index", 
      "insulin resistance", 
      "peptide response", 
      "Organization criteria", 
      "glucose challenge", 
      "insulin concentrations", 
      "split proinsulin", 
      "plasma concentrations", 
      "cell responses", 
      "patients", 
      "immunoradiometric assay", 
      "dystrophy patients", 
      "insulin radioimmunoassay", 
      "dystrophy", 
      "proinsulin", 
      "insulin", 
      "subjects", 
      "radioimmunoassay", 
      "proinsulin molecule", 
      "conventional radioimmunoassay", 
      "hyperinsulinaemia", 
      "hyperproinsulinaemia", 
      "response", 
      "secretion", 
      "age", 
      "corroborative evidence", 
      "concentration", 
      "gender", 
      "group", 
      "assays", 
      "percentage", 
      "peptides", 
      "evidence", 
      "index", 
      "fast", 
      "criteria", 
      "study", 
      "contrast", 
      "tolerance", 
      "resistance", 
      "results", 
      "molecules", 
      "addition", 
      "time", 
      "ratio", 
      "features", 
      "challenges", 
      "means", 
      "phenomenon", 
      "inherited multisystem disorder myotonic dystrophy", 
      "multisystem disorder myotonic dystrophy", 
      "disorder myotonic dystrophy", 
      "compensatory beta cell response", 
      "monoclonal antibody-based immunoradiometric assays", 
      "antibody-based immunoradiometric assays", 
      "Health Organization criteria"
    ], 
    "name": "Hyperproinsulinaemia in patients with myotonic dystrophy", 
    "pagination": "1170-1172", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048912001"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/bf00401372"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1478370"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/bf00401372", 
      "https://app.dimensions.ai/details/publication/pub.1048912001"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T17:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_231.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/bf00401372"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/bf00401372'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/bf00401372'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/bf00401372'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/bf00401372'


 

This table displays all metadata directly associated to this object as RDF triples.

216 TRIPLES      22 PREDICATES      114 URIs      104 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/bf00401372 schema:about N026d701fcaaa4951b89c5f84e6ca0eda
2 N09ade609f0964084a04a742a6d62b71b
3 N1447af6c365941f0a3db234002e2f6b0
4 N27b70ff949ae40d086214d382d82c4df
5 N5a79d599f4984db3a2abd6c1508a58b1
6 N72933e0c3c2941baae9c6acecd44c7ba
7 Nd05d0ba45cde40e3a4cba24e54f37f9b
8 Ne06d6caf071f4598aef02f28fb566c8c
9 Ne64429771ad0473aaa57fab53a896987
10 anzsrc-for:11
11 anzsrc-for:1103
12 schema:author Nf7b2048f9d4d4cc6a256537bf85ee540
13 schema:citation sg:pub.10.1007/bf00273856
14 sg:pub.10.1007/bf00281991
15 schema:datePublished 1992-12
16 schema:datePublishedReg 1992-12-01
17 schema:description Hyperinsulinaemia is a reported feature of the inherited multisystem disorder myotonic dystrophy. This phenomenon has been attributed to a compensatory beta cell response to tissue insulin resistance. In this study, circulating concentrations of insulin, proinsulin, and split proinsulin molecules were determined after an overnight fast in ten patients with myotonic dystrophy using two-site monoclonal antibody-based immunoradiometric assays. Results were compared with ten healthy control subjects matched for age, gender, and body mass index. Oral glucose tolerance (75 g), as defined by World Health Organization criteria, was normal in all subjects. Fasting plasma immunoreactive insulin concentration, as determined using a conventional radioimmunoassay, was almost three times higher (p<0.005) in the myotonic dystrophy patients than the healthy control subjects. By contrast, fasting concentrations (mean±SEM) of C-peptide (0.75±0.09 vs 0.52±0.03 nmol/l, p=0.07) and immunoradiometrically-determined insulin (60±12 vs 38±4 pmol/l, p=0.09) were not significantly different between the groups. Fasting concentrations of proinsulin (10.3±2.9 vs 1.6±0.3 pmol/l, p<0.01), and 32–33 split proinsulin (7.8±2.5 vs 2.9±0.4 pmol/l, p<0.05) were significantly elevated in the patients with myotonic dystrophy. Accordingly, the mean fasting proinsulin∶insulin ratio, expressed as a percentage, was significantly increased in the myotonic patients (20±5 vs 4±1%, p<0.01). The overall C-peptide response to the oral glucose challenge was significantly greater in the myotonic patients compared with the healthy control subjects (p<0.001). These results provide corroborative evidence of increased beta-cell secretion in myotonic dystrophy. In addition, myotonic dystrophy is characterised by elevated plasma concentrations of proinsulin-like molecules which may cross-react in insulin radioimmunoassays.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree true
21 schema:isPartOf N71e6f2727ae24cd88fd43964b8efbd15
22 Neb53530ff1874e45be85398ecd1600bb
23 sg:journal.1001482
24 schema:keywords Health Organization criteria
25 Organization criteria
26 World Health Organization criteria
27 addition
28 age
29 antibody-based immunoradiometric assays
30 assays
31 beta cell response
32 beta-cell secretion
33 body mass index
34 cell responses
35 challenges
36 compensatory beta cell response
37 concentration
38 concentrations of insulin
39 concentrations of proinsulin
40 contrast
41 control subjects
42 conventional radioimmunoassay
43 corroborative evidence
44 criteria
45 disorder myotonic dystrophy
46 dystrophy
47 dystrophy patients
48 elevated plasma concentrations
49 evidence
50 fast
51 features
52 gender
53 glucose challenge
54 glucose tolerance
55 group
56 healthy control subjects
57 hyperinsulinaemia
58 hyperproinsulinaemia
59 immunoradiometric assay
60 immunoreactive insulin concentrations
61 index
62 inherited multisystem disorder myotonic dystrophy
63 insulin
64 insulin concentrations
65 insulin radioimmunoassay
66 insulin resistance
67 mass index
68 means
69 molecules
70 monoclonal antibody-based immunoradiometric assays
71 multisystem disorder myotonic dystrophy
72 myotonic dystrophy
73 myotonic dystrophy patients
74 myotonic patients
75 oral glucose challenge
76 oral glucose tolerance
77 overnight fast
78 patients
79 peptide response
80 peptides
81 percentage
82 phenomenon
83 plasma concentrations
84 plasma immunoreactive insulin concentration
85 proinsulin
86 proinsulin molecule
87 proinsulin-like molecules
88 radioimmunoassay
89 ratio
90 resistance
91 response
92 results
93 secretion
94 split proinsulin
95 study
96 subjects
97 time
98 tolerance
99 two-site monoclonal antibody-based immunoradiometric assays
100 schema:name Hyperproinsulinaemia in patients with myotonic dystrophy
101 schema:pagination 1170-1172
102 schema:productId N2b8db418cc1547f28baf9ce6b0103d89
103 N886ebd2c598047cd8e9bf078611647c3
104 Na5f70faf78cd4c6fbd2a5b6f3980b4fe
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048912001
106 https://doi.org/10.1007/bf00401372
107 schema:sdDatePublished 2021-11-01T17:59
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N8cdfab39fc4347659d1a0bf5fd4c5586
110 schema:url https://doi.org/10.1007/bf00401372
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N026d701fcaaa4951b89c5f84e6ca0eda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N048b83ff7b17459980de147c51eafd0a rdf:first sg:person.01013175117.12
118 rdf:rest rdf:nil
119 N09ade609f0964084a04a742a6d62b71b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name C-Peptide
121 rdf:type schema:DefinedTerm
122 N1447af6c365941f0a3db234002e2f6b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Reference Values
124 rdf:type schema:DefinedTerm
125 N1703feeceee34e9c96d394fc0cab054b rdf:first sg:person.012652700122.10
126 rdf:rest N048b83ff7b17459980de147c51eafd0a
127 N27b70ff949ae40d086214d382d82c4df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Glucose Tolerance Test
129 rdf:type schema:DefinedTerm
130 N2b8db418cc1547f28baf9ce6b0103d89 schema:name doi
131 schema:value 10.1007/bf00401372
132 rdf:type schema:PropertyValue
133 N482ebe72df0e4107b824bc44177998ed rdf:first sg:person.01102473156.15
134 rdf:rest N1703feeceee34e9c96d394fc0cab054b
135 N538e951a517a4aba9c8c8e77ee348a79 rdf:first sg:person.013306426342.70
136 rdf:rest N482ebe72df0e4107b824bc44177998ed
137 N5a79d599f4984db3a2abd6c1508a58b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Insulin
139 rdf:type schema:DefinedTerm
140 N71e6f2727ae24cd88fd43964b8efbd15 schema:volumeNumber 35
141 rdf:type schema:PublicationVolume
142 N72933e0c3c2941baae9c6acecd44c7ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Fasting
144 rdf:type schema:DefinedTerm
145 N886ebd2c598047cd8e9bf078611647c3 schema:name pubmed_id
146 schema:value 1478370
147 rdf:type schema:PropertyValue
148 N8cdfab39fc4347659d1a0bf5fd4c5586 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 Na5f70faf78cd4c6fbd2a5b6f3980b4fe schema:name dimensions_id
151 schema:value pub.1048912001
152 rdf:type schema:PropertyValue
153 Nd05d0ba45cde40e3a4cba24e54f37f9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Radioimmunoassay
155 rdf:type schema:DefinedTerm
156 Ne06d6caf071f4598aef02f28fb566c8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Proinsulin
158 rdf:type schema:DefinedTerm
159 Ne64429771ad0473aaa57fab53a896987 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Myotonic Dystrophy
161 rdf:type schema:DefinedTerm
162 Neb53530ff1874e45be85398ecd1600bb schema:issueNumber 12
163 rdf:type schema:PublicationIssue
164 Nf7b2048f9d4d4cc6a256537bf85ee540 rdf:first sg:person.0676605226.07
165 rdf:rest N538e951a517a4aba9c8c8e77ee348a79
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
170 schema:name Clinical Sciences
171 rdf:type schema:DefinedTerm
172 sg:journal.1001482 schema:issn 0012-186X
173 1432-0428
174 schema:name Diabetologia
175 schema:publisher Springer Nature
176 rdf:type schema:Periodical
177 sg:person.01013175117.12 schema:affiliation grid-institutes:grid.415359.f
178 schema:familyName Nattrass
179 schema:givenName M.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013175117.12
181 rdf:type schema:Person
182 sg:person.01102473156.15 schema:affiliation grid-institutes:grid.415490.d
183 schema:familyName Cox
184 schema:givenName L.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102473156.15
186 rdf:type schema:Person
187 sg:person.012652700122.10 schema:affiliation grid-institutes:grid.120073.7
188 schema:familyName Williams
189 schema:givenName A. C.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012652700122.10
191 rdf:type schema:Person
192 sg:person.013306426342.70 schema:affiliation grid-institutes:grid.415490.d
193 schema:familyName Clark
194 schema:givenName P. M.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013306426342.70
196 rdf:type schema:Person
197 sg:person.0676605226.07 schema:affiliation grid-institutes:grid.415359.f
198 schema:familyName Krentz
199 schema:givenName A. J.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676605226.07
201 rdf:type schema:Person
202 sg:pub.10.1007/bf00273856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080015905
203 https://doi.org/10.1007/bf00273856
204 rdf:type schema:CreativeWork
205 sg:pub.10.1007/bf00281991 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037834209
206 https://doi.org/10.1007/bf00281991
207 rdf:type schema:CreativeWork
208 grid-institutes:grid.120073.7 schema:alternateName Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK
209 schema:name Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK
210 rdf:type schema:Organization
211 grid-institutes:grid.415359.f schema:alternateName Diabetic Clinic, The General Hospital, Birmingham
212 schema:name Diabetic Clinic, The General Hospital, Birmingham
213 rdf:type schema:Organization
214 grid-institutes:grid.415490.d schema:alternateName Department of Clinical Neurology, Queen Elizabeth Hospital, Birmingham
215 schema:name Department of Clinical Neurology, Queen Elizabeth Hospital, Birmingham
216 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...